ENSG00000083093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261584 ENSG00000083093 HEK293_OSMI2_2hA HEK293_TMG_2hB PALB2 protein_coding protein_coding 7.092488 4.788438 9.323653 0.4087554 0.1395452 0.959877 5.0476290 2.7580769 7.2672414 0.11100473 0.09124054 1.394508 0.70225417 0.58336667 0.77993333 0.19656667 0.01138760 0.0113876 FALSE TRUE
ENST00000561514 ENSG00000083093 HEK293_OSMI2_2hA HEK293_TMG_2hB PALB2 protein_coding protein_coding 7.092488 4.788438 9.323653 0.4087554 0.1395452 0.959877 0.3604339 0.1253489 0.4308841 0.03304609 0.10579545 1.703717 0.05287083 0.02763333 0.04623333 0.01860000 0.55747441 0.0113876   TRUE
ENST00000566069 ENSG00000083093 HEK293_OSMI2_2hA HEK293_TMG_2hB PALB2 protein_coding protein_coding 7.092488 4.788438 9.323653 0.4087554 0.1395452 0.959877 0.9477860 1.6170878 0.7113943 0.53977429 0.28738120 -1.173432 0.15200000 0.32346667 0.07556667 -0.24790000 0.03233017 0.0113876   FALSE
ENST00000567003 ENSG00000083093 HEK293_OSMI2_2hA HEK293_TMG_2hB PALB2 protein_coding processed_transcript 7.092488 4.788438 9.323653 0.4087554 0.1395452 0.959877 0.6074366 0.1682819 0.9141336 0.04783486 0.14568906 2.373941 0.07294167 0.03586667 0.09820000 0.06233333 0.05101207 0.0113876   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083093 E001 0.2998086 0.0292243612 5.970812e-01   16 23603160 23603164 5 - 0.088 0.167 1.051
ENSG00000083093 E002 0.5212538 0.0200969741 2.329847e-01 3.659677e-01 16 23603165 23603167 3 - 0.088 0.287 2.054
ENSG00000083093 E003 96.1963125 0.0096336776 1.641648e-07 1.599904e-06 16 23603168 23603669 502 - 1.842 2.137 0.992
ENSG00000083093 E004 52.5185044 0.0043717477 3.841033e-05 2.223593e-04 16 23607864 23608012 149 - 1.615 1.849 0.791
ENSG00000083093 E005 41.4992650 0.0005904376 4.013479e-04 1.779576e-03 16 23614004 23614091 88 - 1.531 1.725 0.658
ENSG00000083093 E006 45.1503179 0.0005193996 1.043792e-02 2.983447e-02 16 23621362 23621478 117 - 1.593 1.729 0.460
ENSG00000083093 E007 55.3941426 0.0005011648 1.481430e-02 4.007434e-02 16 23622969 23623130 162 - 1.691 1.808 0.396
ENSG00000083093 E008 40.2368782 0.0005237524 3.867409e-02 8.857903e-02 16 23624009 23624070 62 - 1.551 1.667 0.397
ENSG00000083093 E009 33.8746306 0.0005892287 4.809168e-03 1.539953e-02 16 23624071 23624094 24 - 1.456 1.626 0.583
ENSG00000083093 E010 54.9001883 0.0004952178 9.668639e-03 2.794646e-02 16 23626236 23626397 162 - 1.677 1.802 0.423
ENSG00000083093 E011 33.5250093 0.0007455610 5.076754e-01 6.431305e-01 16 23629204 23629275 72 - 1.504 1.547 0.146
ENSG00000083093 E012 126.8425052 0.0003379948 2.438233e-01 3.786786e-01 16 23629640 23630469 830 - 2.104 2.069 -0.116
ENSG00000083093 E013 156.9747876 0.0069095729 6.621823e-05 3.618566e-04 16 23634862 23636034 1173 - 2.239 2.060 -0.599
ENSG00000083093 E014 47.7843301 0.0005588033 8.107200e-11 1.452648e-09 16 23636035 23636282 248 - 1.776 1.397 -1.296
ENSG00000083093 E015 21.5219536 0.0024661465 2.700550e-05 1.624162e-04 16 23636283 23636334 52 - 1.438 1.072 -1.292
ENSG00000083093 E016 27.8539877 0.0008947331 3.749700e-06 2.747194e-05 16 23637850 23637952 103 - 1.540 1.192 -1.210
ENSG00000083093 E017 24.7195973 0.0064280219 6.147093e-03 1.899722e-02 16 23638070 23638129 60 - 1.462 1.230 -0.808
ENSG00000083093 E018 7.6190712 0.0103899770 3.575801e-02 8.311757e-02 16 23638459 23638592 134 - 1.002 0.718 -1.096
ENSG00000083093 E019 8.4037168 0.0337230864 3.192574e-02 7.571367e-02 16 23640252 23641109 858 - 1.048 0.720 -1.260
ENSG00000083093 E020 15.8154111 0.0027591057 7.646861e-04 3.131306e-03 16 23641110 23641126 17 - 1.305 0.975 -1.185
ENSG00000083093 E021 20.4424363 0.0046710833 1.484247e-05 9.483193e-05 16 23641127 23641310 184 - 1.424 1.017 -1.442