ENSG00000082781

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296181 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding protein_coding 20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 4.097671 5.5794015 1.9680736 0.5089406 1.0067736 -1.4985977 0.19981250 0.21063333 0.15060000 -0.06003333 7.921981e-01 3.241917e-23 FALSE TRUE
ENST00000461306 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding processed_transcript 20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 2.565729 3.9415181 0.3807987 0.7818860 0.3807987 -3.3379095 0.11302500 0.14906667 0.02333333 -0.12573333 8.648320e-02 3.241917e-23 FALSE FALSE
ENST00000481591 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding protein_coding 20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 1.683642 3.6370818 0.0000000 0.4676514 0.0000000 -8.5105987 0.07646667 0.13606667 0.00000000 -0.13606667 3.241917e-23 3.241917e-23 FALSE TRUE
ENST00000488466 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding protein_coding 20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 1.838747 1.7426504 1.2578983 0.1963553 0.5073883 -0.4670992 0.09327083 0.06513333 0.09116667 0.02603333 9.010566e-01 3.241917e-23 FALSE TRUE
ENST00000608657 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding protein_coding 20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 0.406422 0.0000000 0.8316327 0.0000000 0.8316327 6.3951188 0.02476667 0.00000000 0.05093333 0.05093333 7.295108e-01 3.241917e-23 FALSE FALSE
MSTRG.23561.1 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding   20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 6.085221 9.3750566 5.1253201 0.2936423 0.8340673 -0.8699112 0.30360417 0.35206667 0.40690000 0.05483333 8.390017e-01 3.241917e-23 FALSE TRUE
MSTRG.23561.5 ENSG00000082781 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB5 protein_coding   20.28641 26.62898 13.09578 0.7564162 1.730948 -1.023335 1.451371 0.2210167 2.8610848 0.2210167 0.3997164 3.6355268 0.08649167 0.00790000 0.22330000 0.21540000 5.356745e-03 3.241917e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082781 E001 0.0000000       3 124761899 124761947 49 -      
ENSG00000082781 E002 36.1102277 0.0116278974 6.659621e-03 2.033895e-02 3 124761948 124762947 1000 - 1.667 1.463 -0.696
ENSG00000082781 E003 433.3627706 0.0004546747 2.323248e-11 4.560485e-10 3 124762948 124763718 771 - 2.489 2.627 0.463
ENSG00000082781 E004 165.8501132 0.0019959401 2.660994e-01 4.042511e-01 3 124764391 124764456 66 - 2.144 2.184 0.135
ENSG00000082781 E005 187.8440359 0.0002470766 9.007455e-02 1.752500e-01 3 124764457 124764557 101 - 2.193 2.242 0.165
ENSG00000082781 E006 100.1934543 0.0003679916 3.142841e-02 7.474476e-02 3 124766226 124766229 4 - 1.896 1.982 0.290
ENSG00000082781 E007 163.7639452 0.0012170819 3.450111e-03 1.158211e-02 3 124766230 124766345 116 - 2.096 2.198 0.342
ENSG00000082781 E008 151.2136183 0.0002642602 5.649027e-03 1.768341e-02 3 124769013 124769113 101 - 2.070 2.160 0.302
ENSG00000082781 E009 3.2398251 0.1006519549 1.841239e-01 3.063992e-01 3 124769114 124770182 1069 - 0.758 0.485 -1.203
ENSG00000082781 E010 171.1163613 0.0002646770 4.794464e-03 1.535894e-02 3 124773690 124773818 129 - 2.123 2.210 0.290
ENSG00000082781 E011 161.3315584 0.0013681782 6.553881e-01 7.652847e-01 3 124773819 124773912 94 - 2.150 2.166 0.052
ENSG00000082781 E012 0.0000000       3 124780673 124780704 32 -      
ENSG00000082781 E013 181.8235562 0.0018566461 9.854640e-01 9.949241e-01 3 124796388 124796539 152 - 2.215 2.216 0.003
ENSG00000082781 E014 107.3289938 0.0013867113 9.769902e-02 1.869858e-01 3 124796540 124796590 51 - 1.941 2.011 0.235
ENSG00000082781 E015 212.3778357 0.0016577542 1.308880e-02 3.611574e-02 3 124796591 124796817 227 - 2.220 2.302 0.276
ENSG00000082781 E016 161.8797385 0.0010019726 1.629637e-01 2.790098e-01 3 124809022 124809156 135 - 2.128 2.175 0.160
ENSG00000082781 E017 0.0000000       3 124809337 124809398 62 -      
ENSG00000082781 E018 131.0780516 0.0024656575 8.492598e-01 9.064204e-01 3 124817621 124817710 90 - 2.077 2.071 -0.020
ENSG00000082781 E019 129.0693507 0.0003231430 7.857503e-03 2.342266e-02 3 124819739 124819834 96 - 2.129 2.043 -0.290
ENSG00000082781 E020 86.7286393 0.0003224369 2.985576e-02 7.168100e-02 3 124821313 124821330 18 - 1.957 1.871 -0.288
ENSG00000082781 E021 162.4215219 0.0014645578 6.302417e-02 1.317474e-01 3 124821331 124821474 144 - 2.208 2.147 -0.205
ENSG00000082781 E022 0.5202097 0.0202471272 2.250042e-01 3.564197e-01 3 124832877 124833020 144 - 0.290 0.088 -2.081
ENSG00000082781 E023 87.0929910 0.0003266561 3.778520e-01 5.221559e-01 3 124841383 124841420 38 - 1.921 1.887 -0.117
ENSG00000082781 E024 137.1625485 0.0002706944 4.537774e-01 5.944851e-01 3 124841421 124841551 131 - 2.109 2.085 -0.078
ENSG00000082781 E025 98.2427233 0.0029741188 4.189166e-03 1.367635e-02 3 124848309 124848358 50 - 2.038 1.912 -0.422
ENSG00000082781 E026 112.0471452 0.0013892693 4.274168e-06 3.087620e-05 3 124848359 124848418 60 - 2.124 1.952 -0.579
ENSG00000082781 E027 164.8986436 0.0002311860 2.376587e-08 2.730366e-07 3 124848419 124848558 140 - 2.282 2.124 -0.528
ENSG00000082781 E028 0.0000000       3 124857232 124857313 82 -      
ENSG00000082781 E029 149.9813815 0.0002792745 3.143177e-07 2.895669e-06 3 124859242 124859446 205 - 2.237 2.084 -0.512
ENSG00000082781 E030 59.8240260 0.0020286732 1.567325e-02 4.200794e-02 3 124873446 124873531 86 - 1.825 1.702 -0.416
ENSG00000082781 E031 0.0000000       3 124878603 124878719 117 -      
ENSG00000082781 E032 41.0326692 0.0005466545 3.533775e-04 1.593315e-03 3 124886931 124887365 435 - 1.713 1.515 -0.676
ENSG00000082781 E033 3.3871243 0.0047078027 7.785338e-01 8.575035e-01 3 124887600 124887827 228 - 0.635 0.592 -0.190
ENSG00000082781 E034 0.0000000       3 124894452 124894639 188 -      
ENSG00000082781 E035 6.8902384 0.0024222888 2.104105e-01 3.390230e-01 3 124901266 124901418 153 - 0.957 0.804 -0.586