ENSG00000082641

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357480 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding protein_coding 68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 37.018086 32.5704887 37.675320 3.7750828 0.8183106 0.2099944 0.54786250 0.51380000 0.52620000 0.012400000 9.356213e-01 6.321005e-22 FALSE TRUE
ENST00000361665 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding protein_coding 68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 3.701207 4.1415845 3.542445 0.5160472 0.5983754 -0.2248499 0.05554167 0.06543333 0.04920000 -0.016233333 4.426855e-01 6.321005e-22 FALSE TRUE
ENST00000362042 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding protein_coding 68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 8.020766 6.5039671 8.139517 0.2122521 0.1413143 0.3231781 0.11747500 0.10416667 0.11370000 0.009533333 7.601199e-01 6.321005e-22 FALSE TRUE
ENST00000583060 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding processed_transcript 68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 7.386763 0.0000000 10.086985 0.0000000 2.1095522 9.9797088 0.10068333 0.00000000 0.14206667 0.142066667 1.467924e-19 6.321005e-22   FALSE
ENST00000583378 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding protein_coding 68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 3.665066 13.2979493 0.000000 2.5558330 0.0000000 -10.3780726 0.06015417 0.21576667 0.00000000 -0.215766667 6.321005e-22 6.321005e-22 FALSE TRUE
MSTRG.14582.7 ENSG00000082641 HEK293_OSMI2_2hA HEK293_TMG_2hB NFE2L1 protein_coding   68.09115 62.97669 71.65275 3.249993 1.456985 0.1861765 2.278699 0.8199957 5.991626 0.8199957 1.4101924 2.8541778 0.03124167 0.01200000 0.08296667 0.070966667 7.574209e-02 6.321005e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082641 E001 1.1330771 0.0740034480 8.376280e-01 8.984911e-01 17 48048288 48048317 30 + 0.295 0.362 0.420
ENSG00000082641 E002 1.7264387 0.0393368568 8.787727e-01 9.261395e-01 17 48048318 48048322 5 + 0.419 0.422 0.016
ENSG00000082641 E003 2.8754104 0.0288728456 6.754203e-01 7.807163e-01 17 48048323 48048328 6 + 0.594 0.559 -0.156
ENSG00000082641 E004 23.5366209 0.0189718486 1.953726e-01 3.204262e-01 17 48048329 48048356 28 + 1.426 1.344 -0.282
ENSG00000082641 E005 23.1742458 0.0161419638 7.090721e-02 1.448475e-01 17 48048357 48048358 2 + 1.441 1.316 -0.434
ENSG00000082641 E006 31.2982187 0.0222039715 1.827127e-02 4.772289e-02 17 48048359 48048362 4 + 1.594 1.411 -0.631
ENSG00000082641 E007 43.6468148 0.0048412723 2.427255e-08 2.783849e-07 17 48048363 48048369 7 + 1.784 1.479 -1.036
ENSG00000082641 E008 184.4529790 0.0011221581 6.457206e-19 3.635359e-17 17 48048370 48048462 93 + 2.370 2.148 -0.742
ENSG00000082641 E009 0.0000000       17 48048478 48048548 71 +      
ENSG00000082641 E010 0.0000000       17 48048607 48048648 42 +      
ENSG00000082641 E011 0.4407149 0.0215795713 5.047705e-01 6.406490e-01 17 48048773 48048781 9 + 0.217 0.122 -0.996
ENSG00000082641 E012 0.4407149 0.0215795713 5.047705e-01 6.406490e-01 17 48048782 48048782 1 + 0.217 0.122 -0.996
ENSG00000082641 E013 0.4407149 0.0215795713 5.047705e-01 6.406490e-01 17 48048783 48048783 1 + 0.217 0.122 -0.996
ENSG00000082641 E014 16.2010866 0.0255198929 5.009958e-01 6.371983e-01 17 48048784 48048847 64 + 1.252 1.227 -0.090
ENSG00000082641 E015 16.5279637 0.0271095448 5.010220e-01 6.372116e-01 17 48048848 48048864 17 + 1.260 1.235 -0.089
ENSG00000082641 E016 0.4470576 0.0215296807 5.046791e-01 6.405855e-01 17 48048865 48048877 13 + 0.217 0.122 -0.996
ENSG00000082641 E017 1.0372116 0.0125861286 1.997954e-01 3.259851e-01 17 48049132 48049160 29 + 0.419 0.218 -1.318
ENSG00000082641 E018 468.7516681 0.0002306005 3.510506e-22 2.846981e-20 17 48050607 48050781 175 + 2.730 2.611 -0.394
ENSG00000082641 E019 308.1918213 0.0012040464 7.725352e-07 6.575660e-06 17 48050782 48050819 38 + 2.529 2.451 -0.258
ENSG00000082641 E020 591.9755113 0.0036138861 2.870076e-04 1.327200e-03 17 48050820 48051074 255 + 2.804 2.742 -0.207
ENSG00000082641 E021 189.0376352 0.0002342447 3.704810e-05 2.152498e-04 17 48051075 48051116 42 + 2.308 2.249 -0.195
ENSG00000082641 E022 201.6721872 0.0002395841 4.217543e-09 5.565235e-08 17 48051117 48051146 30 + 2.356 2.256 -0.334
ENSG00000082641 E023 922.5340820 0.0010370990 1.405523e-15 5.213866e-14 17 48051147 48051628 482 + 3.012 2.917 -0.318
ENSG00000082641 E024 1.4080814 0.0412038860 8.873959e-01 9.320316e-01 17 48054328 48054419 92 + 0.362 0.364 0.014
ENSG00000082641 E025 0.9276256 0.2107492060 7.479338e-01 8.353455e-01 17 48054481 48054503 23 + 0.218 0.302 0.627
ENSG00000082641 E026 0.4031496 0.0250150038 2.294691e-01 3.617922e-01 17 48054550 48054586 37 + 0.000 0.218 11.083
ENSG00000082641 E027 0.1817044 0.0400145684 5.363247e-01   17 48054587 48054638 52 + 0.000 0.123 9.850
ENSG00000082641 E028 0.3332198 0.0303790233 9.360915e-01   17 48054675 48054691 17 + 0.122 0.123 0.006
ENSG00000082641 E029 0.3332198 0.0303790233 9.360915e-01   17 48054692 48054709 18 + 0.122 0.123 0.006
ENSG00000082641 E030 0.3332198 0.0303790233 9.360915e-01   17 48054710 48054761 52 + 0.122 0.123 0.006
ENSG00000082641 E031 2.3949536 0.0063268617 3.898294e-01 5.338751e-01 17 48054762 48054919 158 + 0.419 0.595 0.854
ENSG00000082641 E032 1.6951159 0.0082058917 2.730808e-01 4.120583e-01 17 48054920 48054929 10 + 0.295 0.516 1.228
ENSG00000082641 E033 6.7198096 0.0065813504 7.798726e-01 8.585031e-01 17 48054930 48055150 221 + 0.835 0.913 0.298
ENSG00000082641 E034 4.6447516 0.0038046068 6.324975e-01 7.473354e-01 17 48055952 48056040 89 + 0.769 0.745 -0.095
ENSG00000082641 E035 225.5401674 0.0020767122 6.784280e-04 2.820102e-03 17 48056386 48056418 33 + 2.384 2.326 -0.193
ENSG00000082641 E036 490.1313824 0.0022484742 4.479741e-01 5.893197e-01 17 48056419 48056598 180 + 2.671 2.702 0.103
ENSG00000082641 E037 57.2559163 0.0004145075 1.689028e-02 4.469012e-02 17 48057032 48057121 90 + 1.667 1.829 0.549
ENSG00000082641 E038 462.3291674 0.0035297359 9.145467e-01 9.499165e-01 17 48057344 48057502 159 + 2.633 2.687 0.182
ENSG00000082641 E039 2.7365939 0.0066393174 9.912844e-01 9.986442e-01 17 48057768 48057816 49 + 0.556 0.595 0.174
ENSG00000082641 E040 1188.0335775 0.0004000976 1.741295e-01 2.935321e-01 17 48058295 48058876 582 + 3.034 3.102 0.227
ENSG00000082641 E041 896.7565516 0.0008168194 3.918699e-01 5.358135e-01 17 48058877 48059224 348 + 2.913 2.978 0.217
ENSG00000082641 E042 1420.6378946 0.0009945051 3.094416e-03 1.054367e-02 17 48059225 48059917 693 + 3.093 3.192 0.329
ENSG00000082641 E043 2424.7731488 0.0045761860 1.104889e-09 1.625266e-08 17 48059918 48061545 1628 + 3.252 3.468 0.720
ENSG00000082641 E044 3.9856999 0.0064098377 3.909447e-01 5.348883e-01 17 48062212 48062265 54 + 0.744 0.661 -0.343