ENSG00000082515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265229 ENSG00000082515 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL22 protein_coding protein_coding 14.22514 16.32429 15.3011 1.751536 0.5490868 -0.09332583 0.7059988 1.26106131 0.3650355 0.19037450 0.3650355 -1.76093447 0.04674167 0.07683333 0.02303333 -0.05380000 0.16523010 0.04150004 FALSE  
ENST00000523037 ENSG00000082515 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL22 protein_coding protein_coding 14.22514 16.32429 15.3011 1.751536 0.5490868 -0.09332583 12.0573417 14.04692690 13.1163645 1.35660738 0.5045832 -0.09881383 0.84651667 0.86246667 0.85706667 -0.00540000 0.93124019 0.04150004 FALSE  
MSTRG.27221.2 ENSG00000082515 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL22 protein_coding   14.22514 16.32429 15.3011 1.751536 0.5490868 -0.09332583 0.5790766 0.06072831 0.9384576 0.06072831 0.3409854 3.74522356 0.04591250 0.00420000 0.06183333 0.05763333 0.04150004 0.04150004 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082515 E001 0.4407149 0.0212694009 0.435548033 0.577771408 5 154938099 154938112 14 + 0.239 0.110 -1.341
ENSG00000082515 E002 1.5456662 0.1160729573 0.378866338 0.523168756 5 154938113 154938197 85 + 0.504 0.331 -0.938
ENSG00000082515 E003 3.2136264 0.0845768356 0.867223968 0.918607654 5 154940940 154941072 133 + 0.633 0.640 0.030
ENSG00000082515 E004 29.8167599 0.0007491947 0.263651940 0.401566686 5 154941073 154941092 20 + 1.521 1.454 -0.230
ENSG00000082515 E005 31.8753732 0.0008088887 0.299331296 0.440839710 5 154941093 154941094 2 + 1.545 1.484 -0.207
ENSG00000082515 E006 45.8904974 0.0045023516 0.790348923 0.865877288 5 154941095 154941101 7 + 1.673 1.655 -0.061
ENSG00000082515 E007 250.6736173 0.0003852076 0.001300158 0.004977137 5 154941102 154941138 37 + 2.438 2.367 -0.237
ENSG00000082515 E008 6.3376653 0.0048527335 0.373944898 0.518371619 5 154941139 154941176 38 + 0.920 0.813 -0.414
ENSG00000082515 E009 11.3919979 0.0017942143 0.142637348 0.251629289 5 154941177 154941216 40 + 1.163 1.023 -0.505
ENSG00000082515 E010 370.8490921 0.0001817194 0.031170178 0.074229393 5 154941217 154941265 49 + 2.587 2.551 -0.120
ENSG00000082515 E011 2.3466164 0.3222012900 0.054256390 0.116696113 5 154950803 154950820 18 + 0.136 0.667 3.313
ENSG00000082515 E012 577.9391698 0.0001201245 0.410789328 0.554380358 5 154950821 154950938 118 + 2.763 2.755 -0.026
ENSG00000082515 E013 6.6226991 0.0025463539 0.355267555 0.499629904 5 154955199 154956370 1172 + 0.939 0.831 -0.411
ENSG00000082515 E014 557.4160999 0.0001391090 0.461690135 0.601602684 5 154956371 154956436 66 + 2.746 2.739 -0.024
ENSG00000082515 E015 2.2715533 0.0261591342 0.681981710 0.785566642 5 154956437 154957134 698 + 0.552 0.481 -0.339
ENSG00000082515 E016 607.7764292 0.0001281174 0.823612519 0.888867550 5 154957135 154957212 78 + 2.779 2.780 0.001
ENSG00000082515 E017 2.6444148 0.0107793867 0.231005963 0.363673573 5 154959051 154959175 125 + 0.668 0.480 -0.857
ENSG00000082515 E018 496.7410470 0.0001610292 0.003230362 0.010945847 5 154959980 154960049 70 + 2.662 2.712 0.167
ENSG00000082515 E019 540.3830472 0.0009792090 0.001367061 0.005199469 5 154966686 154969411 2726 + 2.688 2.753 0.215