ENSG00000082497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367012 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding protein_coding 4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 1.92450176 1.50659266 2.74786197 0.05844963 0.18309432 0.8627166 0.43009167 0.329466667 0.44616667 0.11670000 5.196350e-02 4.580567e-11 FALSE TRUE
ENST00000482421 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding processed_transcript 4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 0.93811913 2.20014619 0.00000000 0.53907655 0.00000000 -7.7879980 0.21542917 0.475400000 0.00000000 -0.47540000 4.580567e-11 4.580567e-11 FALSE TRUE
ENST00000483884 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding processed_transcript 4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 0.06523896 0.32205668 0.04899649 0.32205668 0.04899649 -2.4927284 0.01822917 0.073400000 0.00800000 -0.06540000 9.622670e-01 4.580567e-11 FALSE TRUE
ENST00000490620 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding processed_transcript 4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 0.20777883 0.01491579 0.76640726 0.01491579 0.27180210 4.9616812 0.04455833 0.003400000 0.12046667 0.11706667 4.510231e-04 4.580567e-11 FALSE TRUE
MSTRG.2980.1 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding   4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 1.20118353 0.52212061 2.23690625 0.13588854 0.23782748 2.0781147 0.27193333 0.114466667 0.36173333 0.24726667 6.234512e-04 4.580567e-11 FALSE TRUE
MSTRG.2980.2 ENSG00000082497 HEK293_OSMI2_2hA HEK293_TMG_2hB SERTAD4 protein_coding   4.436153 4.583637 6.153978 0.09803935 0.350052 0.4242247 0.09933054 0.01780538 0.35380590 0.01780538 0.35380590 3.7097330 0.01975833 0.003833333 0.06366667 0.05983333 1.000000e+00 4.580567e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082497 E001 4.868251 0.0033589702 6.820576e-01 7.856060e-01 1 210232659 210232700 42 + 0.797 0.718 -0.317
ENSG00000082497 E002 8.269376 0.0020174978 4.008076e-02 9.117980e-02 1 210232701 210232795 95 + 1.052 0.783 -1.019
ENSG00000082497 E003 19.227940 0.0012476335 6.975479e-03 2.115931e-02 1 210232796 210233011 216 + 1.386 1.136 -0.878
ENSG00000082497 E004 1.988661 0.0112712201 1.975266e-02 5.096468e-02 1 210237282 210237468 187 + 0.603 0.153 -2.830
ENSG00000082497 E005 0.000000       1 210237943 210237943 1 +      
ENSG00000082497 E006 13.132892 0.0089600097 2.072744e-01 3.352416e-01 1 210237944 210237977 34 + 1.205 1.047 -0.567
ENSG00000082497 E007 32.863627 0.0006634792 1.443060e-02 3.920150e-02 1 210237978 210238135 158 + 1.592 1.414 -0.612
ENSG00000082497 E008 35.753957 0.0014797122 4.892608e-01 6.267089e-01 1 210239493 210239608 116 + 1.592 1.525 -0.229
ENSG00000082497 E009 305.307085 0.0059074318 1.887834e-04 9.159802e-04 1 210241558 210245767 4210 + 2.523 2.413 -0.366
ENSG00000082497 E010 17.930117 0.0058650066 2.826906e-02 6.854149e-02 1 210245768 210245799 32 + 1.198 1.361 0.569
ENSG00000082497 E011 47.409182 0.0006599501 9.720098e-11 1.718149e-09 1 210245800 210245927 128 + 1.533 1.825 0.994
ENSG00000082497 E012 26.459005 0.0007923031 2.010671e-05 1.246329e-04 1 210245928 210246255 328 + 1.307 1.562 0.879
ENSG00000082497 E013 26.700456 0.0300969920 7.044366e-06 4.848796e-05 1 210246572 210246800 229 + 1.206 1.639 1.499