ENSG00000082482

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391894 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding protein_coding 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.02828950 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.06406667 0 0.0000000 0.0000000   0.0004061186 FALSE TRUE
ENST00000391895 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding protein_coding 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.00959440 0.0000000 0.07675520 0.00000000 0.07675520 3.1169502 0.01668750 0 0.1335000 0.1335000 0.9268977006 0.0004061186 FALSE TRUE
ENST00000444842 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding protein_coding 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.24952244 0.2798357 0.33959594 0.04231814 0.02429799 0.2704533 0.70713333 1 0.5699000 -0.4301000 0.0004061186 0.0004061186 FALSE TRUE
ENST00000474771 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding nonsense_mediated_decay 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.07156076 0.0000000 0.10407535 0.00000000 0.10407535 3.5119151 0.11753750 0 0.1593000 0.1593000 0.9237440396 0.0004061186 TRUE TRUE
ENST00000478774 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding protein_coding 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.03543856 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05864583 0 0.0000000 0.0000000   0.0004061186 FALSE FALSE
ENST00000486921 ENSG00000082482 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNK2 protein_coding nonsense_mediated_decay 0.411789 0.2798357 0.5985321 0.04231814 0.0274728 1.070098 0.01443196 0.0000000 0.07810562 0.00000000 0.05591468 3.1392340 0.03019167 0 0.1372667 0.1372667 0.5476825185 0.0004061186 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082482 E001 0.0000000       1 215005775 215005849 75 +      
ENSG00000082482 E002 0.0000000       1 215005850 215005854 5 +      
ENSG00000082482 E003 0.0000000       1 215005855 215005955 101 +      
ENSG00000082482 E004 0.0000000       1 215081793 215081861 69 +      
ENSG00000082482 E005 0.0000000       1 215082122 215082142 21 +      
ENSG00000082482 E006 0.9964241 0.012952045 0.27608894 0.41549538 1 215082737 215083123 387 + 0.200 0.389 1.312
ENSG00000082482 E007 0.0000000       1 215083124 215083234 111 +      
ENSG00000082482 E008 0.2924217 0.030233985 0.27321139   1 215083235 215083307 73 + 0.200 0.001 -8.861
ENSG00000082482 E009 0.4407149 0.023551322 0.70690955 0.80497749 1 215083308 215083431 124 + 0.200 0.134 -0.689
ENSG00000082482 E010 0.0000000       1 215083517 215083664 148 +      
ENSG00000082482 E011 4.6575031 0.003506265 0.01427511 0.03885208 1 215086368 215086678 311 + 0.887 0.549 -1.404
ENSG00000082482 E012 4.3073540 0.004539727 0.69442334 0.79526803 1 215124633 215124750 118 + 0.754 0.698 -0.228
ENSG00000082482 E013 3.1752179 0.005746056 0.23593828 0.36946437 1 215169199 215169245 47 + 0.523 0.698 0.772
ENSG00000082482 E014 1.9896139 0.008133366 0.33494636 0.47868937 1 215169246 215169265 20 + 0.391 0.549 0.798
ENSG00000082482 E015 3.8569735 0.005478613 0.89022420 0.93385920 1 215169266 215169359 94 + 0.681 0.698 0.071
ENSG00000082482 E016 4.5832277 0.003861933 0.96928419 0.98479053 1 215171997 215172183 187 + 0.754 0.757 0.012
ENSG00000082482 E017 2.7042280 0.006870940 0.82988673 0.89319469 1 215194953 215195057 105 + 0.560 0.591 0.141
ENSG00000082482 E018 2.3678877 0.006523914 0.72667713 0.81962156 1 215195058 215195092 35 + 0.560 0.502 -0.273
ENSG00000082482 E019 9.0593968 0.002410563 0.38052374 0.52480579 1 215234828 215235154 327 + 0.963 1.047 0.312
ENSG00000082482 E020 3.6484016 0.005130142 0.74316130 0.83188872 1 215235155 215235179 25 + 0.681 0.630 -0.216
ENSG00000082482 E021 2.7636504 0.005950459 0.78785703 0.86411171 1 215235180 215235191 12 + 0.593 0.549 -0.202
ENSG00000082482 E022 2.3690336 0.006935547 0.38080002 0.52508878 1 215235192 215235217 26 + 0.593 0.449 -0.688
ENSG00000082482 E023 1.5950989 0.009999257 0.35308363 0.49732813 1 215235218 215235219 2 + 0.484 0.320 -0.910
ENSG00000082482 E024 9.4965402 0.002053372 0.82847995 0.89221394 1 215235220 215235690 471 + 1.015 1.033 0.067
ENSG00000082482 E025 6.0420348 0.003642482 0.17367414 0.29296522 1 215235691 215236020 330 + 0.776 0.935 0.615
ENSG00000082482 E026 4.8734594 0.003552522 0.77050540 0.85180717 1 215236021 215237090 1070 + 0.796 0.757 -0.158