ENSG00000082213

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325366 ENSG00000082213 HEK293_OSMI2_2hA HEK293_TMG_2hB C5orf22 protein_coding protein_coding 13.32722 7.225073 19.38402 0.8738573 0.7132387 1.422533 9.1092734 4.645509 14.250182 0.6422522 0.5424237 1.614982 0.68568333 0.6519667 0.73736667 0.08540000 0.797064775 0.000449748 FALSE TRUE
ENST00000504866 ENSG00000082213 HEK293_OSMI2_2hA HEK293_TMG_2hB C5orf22 protein_coding processed_transcript 13.32722 7.225073 19.38402 0.8738573 0.7132387 1.422533 0.4317177 1.456433 0.000000 0.9670636 0.0000000 -7.196168 0.07175417 0.1786333 0.00000000 -0.17863333 0.080837273 0.000449748 FALSE TRUE
ENST00000510530 ENSG00000082213 HEK293_OSMI2_2hA HEK293_TMG_2hB C5orf22 protein_coding retained_intron 13.32722 7.225073 19.38402 0.8738573 0.7132387 1.422533 1.1237968 0.000000 1.101394 0.0000000 0.4938263 6.796226 0.05089583 0.0000000 0.05593333 0.05593333 0.000449748 0.000449748 FALSE FALSE
ENST00000517780 ENSG00000082213 HEK293_OSMI2_2hA HEK293_TMG_2hB C5orf22 protein_coding processed_transcript 13.32722 7.225073 19.38402 0.8738573 0.7132387 1.422533 0.5338558 0.000000 1.067229 0.0000000 0.4907133 6.751181 0.03212917 0.0000000 0.05496667 0.05496667 0.000824408 0.000449748 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082213 E001 0.0000000       5 31532223 31532286 64 +      
ENSG00000082213 E002 0.0000000       5 31532287 31532288 2 +      
ENSG00000082213 E003 0.0000000       5 31532289 31532293 5 +      
ENSG00000082213 E004 0.1515154 0.0429560996 1.000000e+00   5 31532294 31532294 1 + 0.073 0.000 -9.466
ENSG00000082213 E005 0.6277178 0.0198862168 8.730238e-01 9.223942e-01 5 31532295 31532298 4 + 0.191 0.198 0.062
ENSG00000082213 E006 0.8491631 0.0163630208 6.117296e-01 7.308004e-01 5 31532299 31532300 2 + 0.191 0.333 1.064
ENSG00000082213 E007 3.4634775 0.0045819671 8.350338e-01 8.967595e-01 5 31532301 31532306 6 + 0.596 0.649 0.233
ENSG00000082213 E008 6.5905156 0.0030974646 2.183609e-01 3.484339e-01 5 31532307 31532315 9 + 0.860 0.791 -0.270
ENSG00000082213 E009 41.4957212 0.0005211481 3.217158e-01 4.649616e-01 5 31532316 31532473 158 + 1.569 1.622 0.182
ENSG00000082213 E010 39.6502401 0.0005353077 9.764232e-01 9.892584e-01 5 31534272 31534325 54 + 1.530 1.640 0.373
ENSG00000082213 E011 56.8077901 0.0008464626 1.000824e-01 1.906055e-01 5 31534326 31534417 92 + 1.706 1.732 0.089
ENSG00000082213 E012 0.1515154 0.0429560996 1.000000e+00   5 31534418 31534597 180 + 0.073 0.000 -9.464
ENSG00000082213 E013 1.9543299 0.0080985016 7.467709e-01 8.344441e-01 5 31534959 31535051 93 + 0.424 0.436 0.064
ENSG00000082213 E014 84.7986915 0.0003486373 2.277608e-05 1.393329e-04 5 31535744 31535893 150 + 1.904 1.835 -0.234
ENSG00000082213 E015 0.8837216 0.1333619476 1.207369e-01 2.210189e-01 5 31538173 31538259 87 + 0.323 0.000 -12.047
ENSG00000082213 E016 100.0544404 0.0003232714 8.452768e-10 1.269202e-08 5 31538260 31538480 221 + 1.994 1.860 -0.452
ENSG00000082213 E017 38.8045257 0.0072053811 1.236182e-03 4.763369e-03 5 31538481 31538483 3 + 1.589 1.448 -0.483
ENSG00000082213 E018 123.1946452 0.0051338088 9.804008e-04 3.892652e-03 5 31538484 31538689 206 + 2.061 2.010 -0.172
ENSG00000082213 E019 74.7750421 0.0021486414 4.892922e-03 1.563205e-02 5 31540949 31541011 63 + 1.841 1.812 -0.097
ENSG00000082213 E020 92.1336059 0.0008799676 7.892626e-05 4.228245e-04 5 31541281 31541402 122 + 1.939 1.883 -0.187
ENSG00000082213 E021 50.7253337 0.0006649004 7.823174e-02 1.566264e-01 5 31545646 31545670 25 + 1.667 1.683 0.056
ENSG00000082213 E022 63.6583583 0.0004390658 6.098884e-03 1.886978e-02 5 31545671 31545712 42 + 1.772 1.750 -0.072
ENSG00000082213 E023 0.6287620 0.0181522028 3.926892e-01 5.366082e-01 5 31545713 31545714 2 + 0.136 0.333 1.646
ENSG00000082213 E024 9.4242266 0.0022416580 1.409170e-01 2.492838e-01 5 31548490 31548687 198 + 1.000 0.929 -0.268
ENSG00000082213 E025 106.9712949 0.0022230517 3.148538e-04 1.440219e-03 5 31551293 31551432 140 + 2.000 1.955 -0.150
ENSG00000082213 E026 675.4390929 0.0092894188 1.359978e-09 1.966295e-08 5 31552773 31555053 2281 + 2.685 2.967 0.939