ENSG00000082212

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321341 ENSG00000082212 HEK293_OSMI2_2hA HEK293_TMG_2hB ME2 protein_coding protein_coding 7.004814 2.359051 10.86013 0.1552248 0.7153407 2.197988 4.2445935 2.16201791 6.4441445 0.17099388 0.2892099 1.571190 0.6926708 0.9149667 0.59813333 -0.31683333 1.504818e-06 6.241441e-13 FALSE TRUE
ENST00000638768 ENSG00000082212 HEK293_OSMI2_2hA HEK293_TMG_2hB ME2 protein_coding retained_intron 7.004814 2.359051 10.86013 0.1552248 0.7153407 2.197988 1.9900565 0.00000000 3.2940011 0.00000000 0.5923773 8.368070 0.1871292 0.0000000 0.29896667 0.29896667 6.241441e-13 6.241441e-13 FALSE FALSE
ENST00000639688 ENSG00000082212 HEK293_OSMI2_2hA HEK293_TMG_2hB ME2 protein_coding nonsense_mediated_decay 7.004814 2.359051 10.86013 0.1552248 0.7153407 2.197988 0.4431195 0.08860609 0.6649189 0.01743191 0.1405953 2.774966 0.0593625 0.0376000 0.06076667 0.02316667 6.915062e-01 6.241441e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082212 E001 2.9375194 0.0386613946 4.200310e-01 5.632613e-01 18 50879080 50879116 37 + 0.588 0.443 -0.699
ENSG00000082212 E002 2.9375194 0.0386613946 4.200310e-01 5.632613e-01 18 50879117 50879117 1 + 0.588 0.443 -0.699
ENSG00000082212 E003 2.9375194 0.0386613946 4.200310e-01 5.632613e-01 18 50879118 50879118 1 + 0.588 0.443 -0.699
ENSG00000082212 E004 2.9375194 0.0386613946 4.200310e-01 5.632613e-01 18 50879119 50879119 1 + 0.588 0.443 -0.699
ENSG00000082212 E005 17.9513026 0.0009846858 7.457901e-06 5.100274e-05 18 50879120 50879154 35 + 1.317 0.839 -1.743
ENSG00000082212 E006 17.6482718 0.0010278855 1.109212e-05 7.294395e-05 18 50879155 50879156 2 + 1.309 0.839 -1.717
ENSG00000082212 E007 18.5286574 0.0009797790 1.217495e-05 7.929411e-05 18 50879157 50879160 4 + 1.328 0.874 -1.645
ENSG00000082212 E008 19.1156909 0.0010100192 5.771667e-06 4.051072e-05 18 50879161 50879165 5 + 1.342 0.874 -1.695
ENSG00000082212 E009 19.4017699 0.0015289510 4.546747e-06 3.267831e-05 18 50879166 50879170 5 + 1.349 0.874 -1.719
ENSG00000082212 E010 30.9222093 0.0143274852 1.734861e-08 2.046222e-07 18 50879171 50879227 57 + 1.556 0.936 -2.194
ENSG00000082212 E011 55.6805477 0.0035008673 9.861369e-05 5.153674e-04 18 50879228 50879308 81 + 1.753 1.517 -0.802
ENSG00000082212 E012 0.1451727 0.0427878942 1.000000e+00   18 50887513 50887643 131 + 0.072 0.000 -9.739
ENSG00000082212 E013 45.9950717 0.0014133751 9.850688e-02 1.882171e-01 18 50895809 50895824 16 + 1.639 1.554 -0.288
ENSG00000082212 E014 58.3347391 0.0157136017 3.358410e-01 4.796676e-01 18 50895825 50895846 22 + 1.735 1.672 -0.210
ENSG00000082212 E015 85.1211399 0.0112243415 8.381025e-02 1.655163e-01 18 50895847 50895928 82 + 1.907 1.803 -0.347
ENSG00000082212 E016 105.6454153 0.0003296467 2.344787e-03 8.291266e-03 18 50908063 50908188 126 + 2.001 1.897 -0.350
ENSG00000082212 E017 43.3786881 0.0031916838 1.870193e-02 4.867929e-02 18 50908189 50908196 8 + 1.630 1.485 -0.496
ENSG00000082212 E018 110.9207196 0.0002761289 1.605344e-02 4.285480e-02 18 50912801 50912950 150 + 2.017 1.943 -0.249
ENSG00000082212 E019 1.1834165 0.0109098281 4.147302e-01 5.581362e-01 18 50912951 50913266 316 + 0.353 0.201 -1.092
ENSG00000082212 E020 0.8836079 0.0134585728 1.429020e-01 2.519841e-01 18 50915392 50915898 507 + 0.317 0.000 -12.267
ENSG00000082212 E021 0.1515154 0.0424681701 1.000000e+00   18 50915899 50916167 269 + 0.072 0.000 -9.740
ENSG00000082212 E022 83.3734450 0.0003464972 2.815813e-01 4.214897e-01 18 50916168 50916243 76 + 1.884 1.856 -0.095
ENSG00000082212 E023 3.0784257 0.0054766262 3.194510e-01 4.625369e-01 18 50916244 50917346 1103 + 0.608 0.442 -0.786
ENSG00000082212 E024 153.6485922 0.0003309519 4.353775e-01 5.776199e-01 18 50917347 50917508 162 + 2.140 2.134 -0.020
ENSG00000082212 E025 127.8768883 0.0008712359 2.906375e-02 7.012993e-02 18 50918110 50918213 104 + 2.076 2.013 -0.212
ENSG00000082212 E026 121.1147462 0.0002975006 2.704939e-01 4.091587e-01 18 50920456 50920565 110 + 2.041 2.020 -0.070
ENSG00000082212 E027 98.9456171 0.0005870843 3.746699e-01 5.190841e-01 18 50920661 50920758 98 + 1.933 1.987 0.183
ENSG00000082212 E028 112.0586397 0.0002912970 1.340098e-01 2.397265e-01 18 50921074 50921187 114 + 1.981 2.056 0.249
ENSG00000082212 E029 120.8524629 0.0002413286 4.751483e-01 6.138869e-01 18 50924098 50924212 115 + 2.024 2.069 0.151
ENSG00000082212 E030 137.1501387 0.0005822841 7.149462e-01 8.110055e-01 18 50925756 50925898 143 + 2.083 2.116 0.110
ENSG00000082212 E031 119.3188103 0.0014343049 4.931085e-01 6.301591e-01 18 50932258 50932360 103 + 2.018 2.066 0.160
ENSG00000082212 E032 8.9759519 0.0249264183 2.404783e-01 3.747123e-01 18 50932361 50935733 3373 + 0.992 0.837 -0.584
ENSG00000082212 E033 2.7033742 0.0060395275 5.236089e-01 6.572457e-01 18 50939117 50939569 453 + 0.546 0.443 -0.505
ENSG00000082212 E034 85.5255542 0.0005636425 6.186710e-01 7.362424e-01 18 50939570 50939640 71 + 1.875 1.916 0.138
ENSG00000082212 E035 2.8494919 0.0053297255 3.754848e-01 5.199167e-01 18 50939641 50940287 647 + 0.588 0.442 -0.699
ENSG00000082212 E036 111.0025252 0.0003760843 4.076952e-02 9.245245e-02 18 50940288 50940386 99 + 1.971 2.067 0.319
ENSG00000082212 E037 0.2214452 0.0394401243 1.437563e-01   18 50942700 50942736 37 + 0.000 0.202 11.770
ENSG00000082212 E038 0.1515154 0.0424681701 1.000000e+00   18 50945138 50945260 123 + 0.072 0.000 -9.740
ENSG00000082212 E039 408.6841545 0.0023257625 2.448328e-20 1.626897e-18 18 50947017 50954257 7241 + 2.477 2.734 0.855