ENSG00000082175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325455 ENSG00000082175 HEK293_OSMI2_2hA HEK293_TMG_2hB PGR protein_coding protein_coding 0.1268556 0.1329807 0.1581 0.03530638 0.01926457 0.2334993 0.09679632 0.05259359 0.1581 0.008482722 0.01926457 1.425233 0.84301667 0.5217000 1 0.4783000 0.04069257 0.04069257 FALSE TRUE
ENST00000534013 ENSG00000082175 HEK293_OSMI2_2hA HEK293_TMG_2hB PGR protein_coding protein_coding 0.1268556 0.1329807 0.1581 0.03530638 0.01926457 0.2334993 0.01280683 0.04349720 0.0000 0.043497197 0.00000000 -2.419463 0.05991250 0.2617333 0 -0.2617333 0.74188371 0.04069257 FALSE TRUE
ENST00000632634 ENSG00000082175 HEK293_OSMI2_2hA HEK293_TMG_2hB PGR protein_coding protein_coding 0.1268556 0.1329807 0.1581 0.03530638 0.01926457 0.2334993 0.01547430 0.03688991 0.0000 0.036889908 0.00000000 -2.229277 0.08196667 0.2165667 0 -0.2165667 0.64151986 0.04069257 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082175 E001 27.4232521 0.53949987 0.58564422 0.70930802 11 101029624 101038679 9056 - 1.508 1.346 -0.558
ENSG00000082175 E002 0.9524168 0.01411700 0.09434371 0.18189818 11 101038680 101039060 381 - 0.176 0.430 1.758
ENSG00000082175 E003 0.5117019 0.02318769 0.01983918 0.05114682 11 101039061 101039115 55 - 0.000 0.356 27.042
ENSG00000082175 E004 0.9858280 0.01674757 0.09472529 0.18246124 11 101039116 101039271 156 - 0.176 0.430 1.760
ENSG00000082175 E005 0.0000000       11 101041661 101041944 284 -      
ENSG00000082175 E006 1.2772056 0.26381161 0.87326899 0.92258274 11 101041945 101042102 158 - 0.351 0.358 0.039
ENSG00000082175 E007 0.4741261 0.02279863 1.00000000 1.00000000 11 101049929 101049952 24 - 0.176 0.153 -0.239
ENSG00000082175 E008 0.4720498 0.04004086 1.00000000 1.00000000 11 101049953 101050007 55 - 0.176 0.153 -0.238
ENSG00000082175 E009 0.7310603 0.01839470 0.52790896 0.66084809 11 101050008 101050059 52 - 0.301 0.153 -1.241
ENSG00000082175 E010 0.9127647 0.01512138 0.98545483 0.99492369 11 101051424 101051470 47 - 0.301 0.266 -0.240
ENSG00000082175 E011 1.3534796 0.01180461 0.98375311 0.99393065 11 101051471 101051568 98 - 0.398 0.356 -0.241
ENSG00000082175 E012 1.0286788 0.02514504 0.79740576 0.87071823 11 101062447 101062568 122 - 0.352 0.266 -0.565
ENSG00000082175 E013 1.0600137 0.01309216 0.80061093 0.87294008 11 101062569 101062752 184 - 0.352 0.266 -0.562
ENSG00000082175 E014 0.0000000       11 101062753 101064025 1273 -      
ENSG00000082175 E015 0.9127647 0.01512138 0.98545483 0.99492369 11 101091760 101091876 117 - 0.301 0.266 -0.240
ENSG00000082175 E016 0.6192988 0.01948815 0.74253063 0.83139890 11 101126007 101126158 152 - 0.243 0.153 -0.824
ENSG00000082175 E017 0.1482932 0.04327484 0.24371620   11 101126991 101127088 98 - 0.000 0.153 25.455
ENSG00000082175 E018 2.3950579 0.01146596 0.58656275 0.71011179 11 101127434 101129070 1637 - 0.574 0.431 -0.697
ENSG00000082175 E019 0.9138074 0.02214057 0.03229150 0.07641561 11 101129071 101129427 357 - 0.097 0.431 2.764
ENSG00000082175 E020 0.4815130 0.02288148 0.24145937 0.37589161 11 101129428 101129727 300 - 0.097 0.266 1.758
ENSG00000082175 E021 0.0000000       11 101129728 101129813 86 -