ENSG00000082153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409600 ENSG00000082153 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW1 protein_coding protein_coding 123.1774 20.9505 226.5062 0.7913299 3.99073 3.433869 32.330314 13.2003136 59.33292 2.0089358 2.972401 2.167411 0.3842083 0.636966667 0.26200000 -0.37496667 3.789503e-02 4.435643e-14 FALSE TRUE
ENST00000410110 ENSG00000082153 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW1 protein_coding protein_coding 123.1774 20.9505 226.5062 0.7913299 3.99073 3.433869 10.900767 2.0990109 19.13121 1.1455601 2.320292 3.182044 0.1063292 0.099266667 0.08416667 -0.01510000 9.185916e-01 4.435643e-14 FALSE TRUE
ENST00000419090 ENSG00000082153 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW1 protein_coding protein_coding 123.1774 20.9505 226.5062 0.7913299 3.99073 3.433869 55.136985 3.9911523 102.24764 2.6020175 1.911123 4.675649 0.3703583 0.182033333 0.45193333 0.26990000 5.210530e-01 4.435643e-14 FALSE FALSE
ENST00000460660 ENSG00000082153 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW1 protein_coding retained_intron 123.1774 20.9505 226.5062 0.7913299 3.99073 3.433869 9.512556 0.0000000 15.04581 0.0000000 2.816314 10.556104 0.0410875 0.000000000 0.06653333 0.06653333 4.435643e-14 4.435643e-14   FALSE
ENST00000464483 ENSG00000082153 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW1 protein_coding retained_intron 123.1774 20.9505 226.5062 0.7913299 3.99073 3.433869 10.989324 0.1686975 24.01891 0.1090932 3.185257 7.071108 0.0532750 0.008333333 0.10560000 0.09726667 1.109887e-03 4.435643e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082153 E001 0.0000000       2 200810594 200810697 104 +      
ENSG00000082153 E002 0.0000000       2 200811545 200811545 1 +      
ENSG00000082153 E003 67.5274229 0.0240467750 5.388011e-01 6.701831e-01 2 200811546 200811727 182 + 1.675 1.796 0.410
ENSG00000082153 E004 32.5490371 0.0243657963 3.716841e-01 5.161541e-01 2 200811728 200811909 182 + 1.394 1.358 -0.123
ENSG00000082153 E005 51.3531196 0.0009265056 3.558497e-09 4.761917e-08 2 200811910 200811922 13 + 1.628 1.183 -1.544
ENSG00000082153 E006 288.8438437 0.0018459636 4.460927e-08 4.859463e-07 2 200811923 200811946 24 + 2.342 2.205 -0.455
ENSG00000082153 E007 374.1091133 0.0012842683 9.012943e-11 1.602811e-09 2 200811947 200811990 44 + 2.454 2.315 -0.466
ENSG00000082153 E008 0.4396707 0.0309460394 1.000000e+00 1.000000e+00 2 200812185 200812309 125 + 0.140 0.000 -9.137
ENSG00000082153 E009 2.4357186 0.0098688924 7.680161e-01 8.501121e-01 2 200812356 200812493 138 + 0.443 0.427 -0.081
ENSG00000082153 E010 1.9187417 0.0093293535 3.758039e-01 5.202056e-01 2 200812676 200812885 210 + 0.330 0.546 1.142
ENSG00000082153 E011 0.6717251 0.0311305722 5.870283e-01 7.104257e-01 2 200812989 200813050 62 + 0.140 0.265 1.144
ENSG00000082153 E012 610.9665048 0.0006546479 7.652380e-14 2.214326e-12 2 200813208 200813281 74 + 2.662 2.553 -0.366
ENSG00000082153 E013 0.7384352 0.0188065413 4.810857e-01 6.193276e-01 2 200813282 200813404 123 + 0.213 0.000 -9.874
ENSG00000082153 E014 1036.4276944 0.0031406525 2.093836e-05 1.292846e-04 2 200815341 200815517 177 + 2.885 2.822 -0.209
ENSG00000082153 E015 7.7684983 0.0061398555 8.429635e-01 9.021762e-01 2 200815518 200815666 149 + 0.809 0.837 0.109
ENSG00000082153 E016 812.1691177 0.0037902491 1.124094e-03 4.383982e-03 2 200815667 200815761 95 + 2.776 2.730 -0.153
ENSG00000082153 E017 1.0424084 0.1504723669 1.503349e-01 2.621282e-01 2 200815762 200815762 1 + 0.178 0.538 2.275
ENSG00000082153 E018 583.5675905 0.0002440706 2.924326e-05 1.744567e-04 2 200816325 200816390 66 + 2.630 2.610 -0.064
ENSG00000082153 E019 531.2009009 0.0016141521 4.066859e-01 5.503166e-01 2 200817106 200817241 136 + 2.579 2.622 0.142
ENSG00000082153 E020 284.0610478 0.0020084548 6.245196e-01 7.408149e-01 2 200817974 200818033 60 + 2.301 2.384 0.277
ENSG00000082153 E021 380.7571869 0.0026467759 4.995847e-01 6.358745e-01 2 200818034 200818083 50 + 2.435 2.476 0.137
ENSG00000082153 E022 333.9438572 0.0028658826 7.576427e-01 8.423850e-01 2 200818223 200818271 49 + 2.372 2.447 0.253
ENSG00000082153 E023 324.7904854 0.0008365301 1.692998e-01 2.872694e-01 2 200818272 200818325 54 + 2.368 2.396 0.093
ENSG00000082153 E024 414.0052661 0.0007018880 1.227079e-01 2.238224e-01 2 200818326 200818393 68 + 2.473 2.501 0.093
ENSG00000082153 E025 478.1017531 0.0022942484 7.977571e-01 8.709759e-01 2 200818755 200818901 147 + 2.528 2.600 0.242
ENSG00000082153 E026 0.9726796 0.2840289722 8.272477e-01 8.913841e-01 2 200818902 200819124 223 + 0.214 0.268 0.425
ENSG00000082153 E027 167.3390397 0.0026954979 7.619315e-02 1.534237e-01 2 200819982 200820018 37 + 2.062 2.204 0.477
ENSG00000082153 E028 237.1441076 0.0001889017 8.214216e-01 8.874102e-01 2 200820019 200820120 102 + 2.227 2.290 0.211
ENSG00000082153 E029 1.8187367 0.0599468443 5.242336e-01 6.578380e-01 2 200820121 200820195 75 + 0.379 0.264 -0.734
ENSG00000082153 E030 416.8778180 0.0001621787 2.222104e-01 3.530450e-01 2 200821183 200821305 123 + 2.475 2.516 0.138
ENSG00000082153 E031 1855.4766307 0.0258407167 6.294235e-04 2.641145e-03 2 200822147 200827338 5192 + 3.067 3.363 0.983