ENSG00000082146

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000194530 ENSG00000082146 HEK293_OSMI2_2hA HEK293_TMG_2hB STRADB protein_coding protein_coding 31.95361 39.44197 33.54507 4.918846 2.3019 -0.2335664 23.623057 25.32714 27.966747 2.386548 1.823666 0.1429743 0.75735000 0.6468 0.8343 0.1875 6.493591e-08 6.493591e-08 FALSE TRUE
ENST00000415688 ENSG00000082146 HEK293_OSMI2_2hA HEK293_TMG_2hB STRADB protein_coding protein_coding 31.95361 39.44197 33.54507 4.918846 2.3019 -0.2335664 3.508098 12.45430 1.180195 2.852141 1.180195 -3.3885326 0.09482083 0.3087 0.0340 -0.2747 4.102172e-02 6.493591e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082146 E001 0.0000000       2 201387858 201388075 218 +      
ENSG00000082146 E002 1.3306655 0.0104178691 1.055341e-02 3.009834e-02 2 201451610 201451725 116 + 0.565 0.120 -3.073
ENSG00000082146 E003 1.9196616 0.1511879533 7.234588e-03 2.183377e-02 2 201451726 201451730 5 + 0.699 0.119 -3.668
ENSG00000082146 E004 2.6903621 0.2481495235 3.113539e-02 7.416770e-02 2 201451731 201451733 3 + 0.801 0.212 -3.084
ENSG00000082146 E005 3.4203782 0.1863015057 5.055580e-03 1.608418e-02 2 201451734 201451739 6 + 0.902 0.212 -3.471
ENSG00000082146 E006 31.0923958 0.1309346234 2.245265e-04 1.068499e-03 2 201451740 201451795 56 + 1.762 1.057 -2.450
ENSG00000082146 E007 81.6048091 0.0402802185 4.084563e-03 1.337958e-02 2 201451796 201451938 143 + 2.062 1.747 -1.060
ENSG00000082146 E008 54.2395614 0.0218130658 2.557521e-03 8.934606e-03 2 201454746 201454748 3 + 1.869 1.602 -0.901
ENSG00000082146 E009 132.8608926 0.0138476894 3.325002e-02 7.829074e-02 2 201454749 201454852 104 + 2.198 2.059 -0.464
ENSG00000082146 E010 3.0465191 0.0071987503 9.407026e-01 9.667326e-01 2 201457379 201457450 72 + 0.602 0.620 0.079
ENSG00000082146 E011 172.3649878 0.0039228462 8.266955e-03 2.445886e-02 2 201458784 201458864 81 + 2.293 2.192 -0.337
ENSG00000082146 E012 230.6679669 0.0010289227 2.151549e-06 1.661590e-05 2 201469953 201470052 100 + 2.428 2.306 -0.408
ENSG00000082146 E013 0.3268771 0.0292089987 9.725544e-01   2 201472857 201472954 98 + 0.125 0.120 -0.071
ENSG00000082146 E014 241.6608352 0.0002033092 3.079346e-05 1.827037e-04 2 201472955 201473076 122 + 2.432 2.347 -0.284
ENSG00000082146 E015 0.9953799 0.0124916509 9.324200e-01 9.614282e-01 2 201474622 201474646 25 + 0.301 0.291 -0.071
ENSG00000082146 E016 107.9992449 0.0002989337 4.284558e-01 5.712151e-01 2 201474647 201474650 4 + 2.048 2.031 -0.060
ENSG00000082146 E017 195.6848967 0.0002117317 8.135888e-01 8.818286e-01 2 201474651 201474755 105 + 2.294 2.297 0.011
ENSG00000082146 E018 156.0254846 0.0002492110 7.718793e-01 8.527737e-01 2 201475619 201475670 52 + 2.189 2.206 0.059
ENSG00000082146 E019 182.4933563 0.0002356065 9.592179e-01 9.784500e-01 2 201475671 201475742 72 + 2.262 2.270 0.026
ENSG00000082146 E020 253.9121473 0.0002934749 8.241416e-01 8.892106e-01 2 201477619 201477790 172 + 2.402 2.416 0.047
ENSG00000082146 E021 163.7362056 0.0002658303 7.115622e-01 8.084981e-01 2 201478087 201478149 63 + 2.212 2.232 0.067
ENSG00000082146 E022 144.0486261 0.0003197846 2.544726e-02 6.280085e-02 2 201478150 201478191 42 + 2.124 2.201 0.256
ENSG00000082146 E023 3.3666922 0.0829371585 1.100478e-01 2.056120e-01 2 201478192 201478356 165 + 0.779 0.465 -1.383
ENSG00000082146 E024 285.7250516 0.0010294750 5.798842e-03 1.808440e-02 2 201478357 201478562 206 + 2.415 2.494 0.261
ENSG00000082146 E025 169.3077579 0.0031819305 3.499284e-01 4.941257e-01 2 201478563 201478601 39 + 2.208 2.253 0.148
ENSG00000082146 E026 6.7656482 0.1318217992 2.427716e-01 3.774381e-01 2 201479142 201479488 347 + 1.001 0.749 -0.968
ENSG00000082146 E027 185.3073721 0.0023374616 7.434884e-02 1.504987e-01 2 201479489 201479531 43 + 2.233 2.304 0.239
ENSG00000082146 E028 4.2770368 0.0493385194 4.556319e-01 5.961441e-01 2 201480008 201480031 24 + 0.778 0.655 -0.509
ENSG00000082146 E029 789.2547754 0.0032776643 9.720067e-09 1.201512e-07 2 201480032 201480846 815 + 2.807 2.957 0.499