ENSG00000082068

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265107 ENSG00000082068 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR70 protein_coding protein_coding 19.06545 9.57671 28.63606 0.3883332 0.7326658 1.579229 10.471739 7.1776140 14.640279 0.6581896 0.2970387 1.027343 0.58820417 0.7466 0.51213333 -0.23446667 1.528323e-03 3.16146e-16 FALSE TRUE
ENST00000504564 ENSG00000082068 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR70 protein_coding protein_coding 19.06545 9.57671 28.63606 0.3883332 0.7326658 1.579229 2.652863 0.0000000 5.643336 0.0000000 1.1070192 9.142959 0.11011250 0.0000 0.19540000 0.19540000 3.161460e-16 3.16146e-16 FALSE TRUE
ENST00000510699 ENSG00000082068 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR70 protein_coding processed_transcript 19.06545 9.57671 28.63606 0.3883332 0.7326658 1.579229 4.327383 1.2012660 6.471875 0.6021387 0.6087732 2.419896 0.20975000 0.1300 0.22713333 0.09713333 6.991398e-01 3.16146e-16 FALSE FALSE
MSTRG.26076.1 ENSG00000082068 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR70 protein_coding   19.06545 9.57671 28.63606 0.3883332 0.7326658 1.579229 1.028017 0.8698669 1.421863 0.1501195 0.3575343 0.702536 0.06066667 0.0903 0.04926667 -0.04103333 2.449085e-01 3.16146e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000082068 E001 1.1790483 0.3858777753 9.272676e-01 9.582277e-01 5 37379232 37379279 48 + 0.328 0.369 0.251
ENSG00000082068 E002 1.1833147 0.0677222723 8.419479e-01 9.014520e-01 5 37379280 37379284 5 + 0.328 0.379 0.301
ENSG00000082068 E003 1.0360657 0.0186972602 5.979206e-01 7.196194e-01 5 37379285 37379287 3 + 0.279 0.381 0.635
ENSG00000082068 E004 2.2088731 0.1914884352 5.924380e-01 7.149903e-01 5 37379288 37379301 14 + 0.541 0.449 -0.453
ENSG00000082068 E005 11.8525296 0.0327344800 1.194132e-01 2.191082e-01 5 37379302 37379317 16 + 1.162 0.952 -0.765
ENSG00000082068 E006 67.6634031 0.0003947482 3.314819e-03 1.119119e-02 5 37379318 37379392 75 + 1.866 1.736 -0.439
ENSG00000082068 E007 92.9855096 0.0004391536 3.218648e-03 1.091045e-02 5 37379489 37379554 66 + 1.998 1.886 -0.374
ENSG00000082068 E008 124.9481724 0.0002946171 1.170192e-04 6.001664e-04 5 37381602 37381685 84 + 2.129 2.004 -0.421
ENSG00000082068 E009 0.0000000       5 37381686 37381809 124 +      
ENSG00000082068 E010 78.7556256 0.0005563978 1.931461e-04 9.344679e-04 5 37392000 37392002 3 + 1.940 1.782 -0.531
ENSG00000082068 E011 148.5632325 0.0007088108 8.690034e-05 4.605424e-04 5 37392003 37392120 118 + 2.203 2.079 -0.416
ENSG00000082068 E012 111.9321499 0.0100810455 9.272343e-02 1.793784e-01 5 37396375 37396460 86 + 2.073 1.967 -0.353
ENSG00000082068 E013 121.9265468 0.0030430867 5.075384e-02 1.105128e-01 5 37396461 37396570 110 + 2.102 2.018 -0.281
ENSG00000082068 E014 103.6254052 0.0003918655 3.157818e-02 7.502655e-02 5 37437922 37437981 60 + 2.030 1.955 -0.252
ENSG00000082068 E015 146.4665747 0.0005588776 4.366162e-04 1.915157e-03 5 37443239 37443372 134 + 2.192 2.083 -0.366
ENSG00000082068 E016 0.5181333 0.0198804770 1.000000e+00 1.000000e+00 5 37479470 37479512 43 + 0.162 0.167 0.056
ENSG00000082068 E017 170.5285482 0.0012452649 1.632056e-01 2.793355e-01 5 37479834 37479987 154 + 2.238 2.197 -0.135
ENSG00000082068 E018 112.1643839 0.0002698152 1.302761e-01 2.345491e-01 5 37516514 37516590 77 + 2.021 2.078 0.191
ENSG00000082068 E019 185.1642543 0.0004059500 9.072254e-01 9.450791e-01 5 37605064 37605238 175 + 2.254 2.262 0.027
ENSG00000082068 E020 0.1451727 0.0429762727 1.000000e+00   5 37687910 37688007 98 + 0.088 0.000 -8.300
ENSG00000082068 E021 123.8315756 0.0009904692 6.719226e-01 7.780552e-01 5 37697655 37697754 100 + 2.087 2.076 -0.036
ENSG00000082068 E022 0.3289534 0.0274424043 5.954671e-01   5 37697755 37697907 153 + 0.088 0.167 1.055
ENSG00000082068 E023 124.7907679 0.0005070796 7.933667e-01 8.678852e-01 5 37701058 37701142 85 + 2.081 2.094 0.045
ENSG00000082068 E024 170.9115396 0.0002494038 6.509494e-01 7.619238e-01 5 37702949 37703087 139 + 2.226 2.219 -0.025
ENSG00000082068 E025 151.8876366 0.0003104646 9.562092e-03 2.769003e-02 5 37721115 37721215 101 + 2.142 2.224 0.274
ENSG00000082068 E026 15.0844333 0.0183595019 4.913365e-01 6.286154e-01 5 37721216 37722642 1427 + 1.225 1.159 -0.234
ENSG00000082068 E027 5.2778304 0.0033744437 6.678255e-01 7.749772e-01 5 37722643 37722854 212 + 0.759 0.821 0.247
ENSG00000082068 E028 144.8762226 0.0005472227 1.002706e-01 1.908969e-01 5 37722855 37722934 80 + 2.131 2.188 0.191
ENSG00000082068 E029 14.6169541 0.0085788701 3.252051e-01 4.686459e-01 5 37722935 37724842 1908 + 1.142 1.241 0.350
ENSG00000082068 E030 1.9102314 0.0095194745 7.511007e-03 2.254302e-02 5 37724843 37724933 91 + 0.225 0.677 2.471
ENSG00000082068 E031 164.4876924 0.0007643606 2.144817e-04 1.026213e-03 5 37724934 37725050 117 + 2.161 2.278 0.390
ENSG00000082068 E032 173.9708526 0.0038039226 4.390248e-09 5.779441e-08 5 37726883 37727045 163 + 2.129 2.365 0.789
ENSG00000082068 E033 125.1524809 0.0014012549 8.465446e-13 2.103283e-11 5 37752486 37753435 950 + 1.978 2.238 0.870