ENSG00000081913

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262719 ENSG00000081913 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP1 protein_coding protein_coding 5.212567 4.655975 5.662245 0.2688974 0.1573807 0.2817413 4.1417555 4.601539 3.575709 0.2425931 0.05057052 -0.3629901 0.8079417 0.9889667 0.6328333 -0.3561333 1.339068e-14 2.936569e-23 FALSE TRUE
MSTRG.15877.2 ENSG00000081913 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP1 protein_coding   5.212567 4.655975 5.662245 0.2688974 0.1573807 0.2817413 0.9646662 0.000000 2.002842 0.0000000 0.20210826 7.6530901 0.1723458 0.0000000 0.3523333 0.3523333 2.936569e-23 2.936569e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081913 E001 37.2914938 0.0575482022 2.849755e-04 1.318736e-03 18 62715541 62717100 1560 + 1.724 1.377 -1.187
ENSG00000081913 E002 19.6354295 0.0009902656 3.418564e-07 3.126565e-06 18 62717101 62717259 159 + 1.444 1.138 -1.072
ENSG00000081913 E003 0.0000000       18 62779399 62779568 170 +      
ENSG00000081913 E004 36.1622133 0.0030980391 2.874647e-07 2.671229e-06 18 62830035 62830231 197 + 1.668 1.440 -0.778
ENSG00000081913 E005 0.0000000       18 62832160 62832173 14 +      
ENSG00000081913 E006 0.0000000       18 62832174 62832327 154 +      
ENSG00000081913 E007 0.1472490 0.0429050247 4.426593e-01   18 62837678 62838783 1106 + 0.117 0.000 -9.754
ENSG00000081913 E008 31.1171645 0.0006831267 1.456927e-05 9.320587e-05 18 62838784 62838909 126 + 1.586 1.411 -0.600
ENSG00000081913 E009 0.0000000       18 62838910 62839875 966 +      
ENSG00000081913 E010 0.0000000       18 62842935 62843074 140 +      
ENSG00000081913 E011 33.2444715 0.0006949434 8.303382e-04 3.367552e-03 18 62860435 62860601 167 + 1.583 1.476 -0.365
ENSG00000081913 E012 0.0000000       18 62889568 62889665 98 +      
ENSG00000081913 E013 34.2536189 0.0020819855 2.932925e-03 1.006619e-02 18 62895011 62895157 147 + 1.590 1.500 -0.306
ENSG00000081913 E014 51.4540429 0.0005243347 5.121772e-05 2.878729e-04 18 62895781 62896011 231 + 1.768 1.667 -0.342
ENSG00000081913 E015 44.5022066 0.0127819077 1.415021e-02 3.856661e-02 18 62902964 62903149 186 + 1.696 1.615 -0.273
ENSG00000081913 E016 18.8647431 0.0144060675 9.033334e-02 1.756461e-01 18 62903150 62903166 17 + 1.328 1.262 -0.232
ENSG00000081913 E017 27.5883808 0.0008714764 1.768418e-02 4.645462e-02 18 62905224 62905284 61 + 1.485 1.423 -0.214
ENSG00000081913 E018 0.1817044 0.0394815499 5.363606e-01   18 62906287 62906390 104 + 0.000 0.128 9.231
ENSG00000081913 E019 32.7070088 0.0007352316 1.713339e-03 6.323899e-03 18 62914913 62915008 96 + 1.575 1.481 -0.325
ENSG00000081913 E020 45.7151573 0.0005225731 5.255220e-04 2.255007e-03 18 62919959 62920114 156 + 1.709 1.626 -0.281
ENSG00000081913 E021 54.4738256 0.0004731833 2.114719e-03 7.580276e-03 18 62941718 62941918 201 + 1.768 1.718 -0.167
ENSG00000081913 E022 39.9381898 0.0006250802 5.169374e-01 6.514397e-01 18 62945109 62945271 163 + 1.535 1.664 0.440
ENSG00000081913 E023 0.3686942 0.0300296421 9.390003e-01 9.656956e-01 18 62957026 62957052 27 + 0.117 0.129 0.164
ENSG00000081913 E024 41.2234987 0.0005094868 4.252448e-01 5.681857e-01 18 62958629 62958759 131 + 1.546 1.683 0.465
ENSG00000081913 E025 40.9342964 0.0005329009 3.249304e-01 4.683533e-01 18 62963368 62963472 105 + 1.600 1.640 0.138
ENSG00000081913 E026 57.7264982 0.0004225655 7.067359e-01 8.048486e-01 18 62972514 62972708 195 + 1.724 1.801 0.260
ENSG00000081913 E027 66.9578358 0.0005047763 5.352279e-01 6.671490e-01 18 62975397 62975625 229 + 1.758 1.879 0.408
ENSG00000081913 E028 410.0831268 0.0126559782 2.774807e-12 6.336533e-11 18 62978262 62980433 2172 + 2.377 2.756 1.260