ENSG00000081803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397721 ENSG00000081803 HEK293_OSMI2_2hA HEK293_TMG_2hB CADPS2 protein_coding protein_coding 4.65656 2.596957 7.481086 0.2112657 0.1971892 1.522808 1.2038502 0.4331376 1.6410500 0.2167858 0.33429131 1.8975573 0.24449167 0.1543667 0.2206000 0.06623333 0.7602970757 0.0001657507 FALSE TRUE
ENST00000412584 ENSG00000081803 HEK293_OSMI2_2hA HEK293_TMG_2hB CADPS2 protein_coding protein_coding 4.65656 2.596957 7.481086 0.2112657 0.1971892 1.522808 1.9424309 0.9088223 3.2223201 0.1192632 0.02147634 1.8147123 0.40577917 0.3616667 0.4314000 0.06973333 0.6675040102 0.0001657507 FALSE TRUE
ENST00000462699 ENSG00000081803 HEK293_OSMI2_2hA HEK293_TMG_2hB CADPS2 protein_coding protein_coding 4.65656 2.596957 7.481086 0.2112657 0.1971892 1.522808 1.1275392 1.1574415 1.6271800 0.1295705 0.14355413 0.4878626 0.28307083 0.4446667 0.2176333 -0.22703333 0.0001657507 0.0001657507 FALSE TRUE
MSTRG.30582.5 ENSG00000081803 HEK293_OSMI2_2hA HEK293_TMG_2hB CADPS2 protein_coding   4.65656 2.596957 7.481086 0.2112657 0.1971892 1.522808 0.2794686 0.0000000 0.8189634 0.0000000 0.36872369 6.3732366 0.04310833 0.0000000 0.1077000 0.10770000 0.0015245429 0.0001657507 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081803 E001 0.0000000       7 122318411 122318424 14 -      
ENSG00000081803 E002 4.2855205 0.0472170363 1.954199e-02 5.050367e-02 7 122318425 122319398 974 - 0.551 0.928 1.549
ENSG00000081803 E003 34.5804267 0.0011079526 1.053162e-05 6.965697e-05 7 122319399 122319745 347 - 1.424 1.690 0.910
ENSG00000081803 E004 41.6500612 0.0006191007 1.277452e-06 1.037154e-05 7 122319746 122320012 267 - 1.500 1.765 0.900
ENSG00000081803 E005 17.3469327 0.0010382132 9.515323e-02 1.831049e-01 7 122320013 122320036 24 - 1.180 1.321 0.498
ENSG00000081803 E006 68.9291259 0.0004235876 3.391557e-04 1.537056e-03 7 122320037 122320338 302 - 1.758 1.913 0.522
ENSG00000081803 E007 46.0784988 0.0005189033 7.141409e-02 1.456787e-01 7 122325477 122325581 105 - 1.603 1.700 0.330
ENSG00000081803 E008 40.9129804 0.0007004627 6.708842e-02 1.385208e-01 7 122345574 122345681 108 - 1.551 1.656 0.357
ENSG00000081803 E009 20.2173501 0.0009860612 1.610086e-01 2.764344e-01 7 122360788 122360820 33 - 1.252 1.364 0.390
ENSG00000081803 E010 29.5210383 0.0007195263 7.160471e-03 2.163893e-02 7 122360930 122361013 84 - 1.387 1.564 0.608
ENSG00000081803 E011 25.8540118 0.0020156638 6.581628e-02 1.363981e-01 7 122379368 122379442 75 - 1.346 1.479 0.459
ENSG00000081803 E012 10.9482657 0.0016263129 1.017488e-02 2.919635e-02 7 122386295 122386309 15 - 0.947 1.207 0.944
ENSG00000081803 E013 37.6662201 0.0054120777 3.720880e-01 5.165611e-01 7 122387026 122387173 148 - 1.531 1.590 0.200
ENSG00000081803 E014 39.2788510 0.0056642756 6.636872e-01 7.716886e-01 7 122388583 122388738 156 - 1.560 1.589 0.098
ENSG00000081803 E015 1.0620900 0.0390508188 9.133371e-01 9.490764e-01 7 122393196 122393315 120 - 0.297 0.317 0.135
ENSG00000081803 E016 36.1967034 0.0006122787 1.808063e-01 3.022102e-01 7 122393441 122393582 142 - 1.513 1.594 0.277
ENSG00000081803 E017 35.9250067 0.0006129574 9.901421e-02 1.889648e-01 7 122407540 122407696 157 - 1.500 1.600 0.342
ENSG00000081803 E018 0.1472490 0.0452596395 1.000000e+00   7 122414068 122414076 9 - 0.078 0.000 -8.158
ENSG00000081803 E019 25.7081105 0.0142125574 4.061512e-01 5.497973e-01 7 122416061 122416164 104 - 1.362 1.441 0.273
ENSG00000081803 E020 3.5451769 0.0046607148 5.926396e-01 7.151451e-01 7 122436360 122436380 21 - 0.656 0.568 -0.390
ENSG00000081803 E021 30.5521183 0.0214661364 8.542476e-01 9.098368e-01 7 122438341 122438464 124 - 1.464 1.445 -0.065
ENSG00000081803 E022 20.3858757 0.0234831739 8.503209e-01 9.071446e-01 7 122441512 122441575 64 - 1.290 1.300 0.036
ENSG00000081803 E023 24.4842485 0.0009328054 1.045541e-01 1.974427e-01 7 122451374 122451475 102 - 1.404 1.274 -0.451
ENSG00000081803 E024 34.2475961 0.0005952922 8.219855e-02 1.629751e-01 7 122471375 122471562 188 - 1.546 1.430 -0.400
ENSG00000081803 E025 26.9991222 0.0185578928 2.989872e-01 4.404733e-01 7 122474381 122474517 137 - 1.446 1.349 -0.335
ENSG00000081803 E026 0.1515154 0.0430371602 1.000000e+00   7 122480852 122480860 9 - 0.078 0.000 -8.159
ENSG00000081803 E027 31.2204533 0.0007120068 7.052846e-02 1.442184e-01 7 122490081 122490281 201 - 1.511 1.384 -0.438
ENSG00000081803 E028 22.2377244 0.0008789486 2.359393e-02 5.897456e-02 7 122491312 122491417 106 - 1.383 1.192 -0.670
ENSG00000081803 E029 12.8654567 0.0014315677 1.187366e-01 2.181349e-01 7 122491418 122491420 3 - 1.151 0.984 -0.608
ENSG00000081803 E030 22.3225178 0.0008835028 1.365964e-02 3.745029e-02 7 122513249 122513315 67 - 1.387 1.177 -0.736
ENSG00000081803 E031 26.2793691 0.0007336406 6.119720e-04 2.576934e-03 7 122554550 122554689 140 - 1.469 1.192 -0.967
ENSG00000081803 E032 25.9815496 0.0007599063 7.088603e-04 2.930784e-03 7 122581179 122581290 112 - 1.466 1.192 -0.957
ENSG00000081803 E033 0.0000000       7 122585512 122585761 250 -      
ENSG00000081803 E034 29.0896497 0.0048562864 7.769685e-03 2.320104e-02 7 122615181 122615299 119 - 1.503 1.286 -0.753
ENSG00000081803 E035 33.5011634 0.0005967732 2.279531e-03 8.088751e-03 7 122621481 122621717 237 - 1.558 1.343 -0.740
ENSG00000081803 E036 19.3954431 0.0014065000 2.860809e-02 6.922603e-02 7 122629248 122629328 81 - 1.327 1.127 -0.704
ENSG00000081803 E037 40.2738794 0.0007802050 9.678741e-06 6.457050e-05 7 122663237 122663569 333 - 1.651 1.354 -1.020
ENSG00000081803 E038 18.8838589 0.0111761936 8.919900e-04 3.586113e-03 7 122736955 122737068 114 - 1.350 0.983 -1.311
ENSG00000081803 E039 31.7105154 0.0006861893 1.037795e-03 4.089421e-03 7 122885999 122886759 761 - 1.539 1.299 -0.830