ENSG00000081791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000194118 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding protein_coding 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 3.509839 5.979032 2.355170 0.4084397 0.1981257 -1.34037902 0.09342083 0.13940000 0.08003333 -0.05936667 0.004707236 0.004707236 FALSE  
ENST00000432126 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding protein_coding 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 4.433970 5.336659 3.250023 0.2952463 0.1503756 -0.71375545 0.12015417 0.12456667 0.11073333 -0.01383333 0.718696221 0.004707236 FALSE  
ENST00000502729 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding retained_intron 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 5.916335 6.537143 4.611878 0.2850838 0.3735867 -0.50238633 0.16132500 0.15193333 0.15653333 0.00460000 0.935927664 0.004707236 FALSE  
ENST00000506775 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding processed_transcript 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 3.865522 3.946234 3.221634 0.3317444 0.1514817 -0.29186400 0.10730833 0.09230000 0.10980000 0.01750000 0.618546827 0.004707236    
ENST00000508751 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding protein_coding 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 7.115019 6.558438 6.243731 1.3161540 0.2491695 -0.07083322 0.19250417 0.15200000 0.21273333 0.06073333 0.401875599 0.004707236 FALSE  
ENST00000509110 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding retained_intron 36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 2.213447 2.100432 2.060862 0.2998097 0.2593019 -0.02730687 0.06031667 0.04856667 0.06986667 0.02130000 0.269311361 0.004707236    
MSTRG.27079.7 ENSG00000081791 HEK293_OSMI2_2hA HEK293_TMG_2hB DELE1 protein_coding   36.72436 43.00203 29.39978 1.090165 0.4795563 -0.5484445 7.757263 9.641096 6.549811 0.9333036 0.1505155 -0.55703851 0.21433750 0.22376667 0.22296667 -0.00080000 1.000000000 0.004707236 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081791 E001 0.000000       5 141923084 141923101 18 +      
ENSG00000081791 E002 0.000000       5 141923102 141923104 3 +      
ENSG00000081791 E003 0.000000       5 141923105 141923110 6 +      
ENSG00000081791 E004 0.000000       5 141923111 141923435 325 +      
ENSG00000081791 E005 0.147249 0.0428409762 2.518749e-01   5 141923436 141923626 191 + 0.163 0.000 -10.129
ENSG00000081791 E006 0.147249 0.0428409762 2.518749e-01   5 141923627 141923744 118 + 0.163 0.000 -12.825
ENSG00000081791 E007 33.688313 0.0006256345 8.653744e-03 2.541706e-02 5 141923745 141923854 110 + 1.608 1.451 -0.538
ENSG00000081791 E008 64.160975 0.0031878803 3.977008e-02 9.059923e-02 5 141923855 141923870 16 + 1.843 1.738 -0.353
ENSG00000081791 E009 117.530072 0.0002476679 1.203473e-03 4.652375e-03 5 141923871 141923909 39 + 2.107 2.001 -0.355
ENSG00000081791 E010 171.479958 0.0002421270 4.214913e-04 1.856681e-03 5 141923910 141923972 63 + 2.261 2.165 -0.322
ENSG00000081791 E011 243.337536 0.0001708309 5.359873e-04 2.294509e-03 5 141924581 141924695 115 + 2.403 2.325 -0.261
ENSG00000081791 E012 265.629776 0.0002239758 1.506340e-02 4.063270e-02 5 141925410 141925527 118 + 2.424 2.372 -0.174
ENSG00000081791 E013 248.989479 0.0003625935 8.067248e-02 1.605981e-01 5 141928151 141928298 148 + 2.388 2.349 -0.129
ENSG00000081791 E014 298.186323 0.0003569161 2.844134e-02 6.889571e-02 5 141929582 141929740 159 + 2.470 2.425 -0.151
ENSG00000081791 E015 208.951642 0.0006401619 1.423234e-01 2.512111e-01 5 141929989 141930074 86 + 2.309 2.272 -0.123
ENSG00000081791 E016 170.039984 0.0002619126 9.163488e-01 9.511209e-01 5 141930178 141930246 69 + 2.190 2.197 0.024
ENSG00000081791 E017 128.535377 0.0005848441 1.589017e-01 2.736824e-01 5 141930247 141930274 28 + 2.038 2.092 0.180
ENSG00000081791 E018 7.206063 0.0023754468 4.482175e-06 3.226195e-05 5 141931219 141931280 62 + 1.179 0.652 -2.013
ENSG00000081791 E019 264.516620 0.0001963642 1.243066e-01 2.261398e-01 5 141933259 141933401 143 + 2.355 2.396 0.135
ENSG00000081791 E020 55.057100 0.0040705122 6.871439e-02 1.412346e-01 5 141933402 141933882 481 + 1.779 1.681 -0.333
ENSG00000081791 E021 124.094830 0.0013233594 9.773358e-01 9.898760e-01 5 141934240 141934257 18 + 2.053 2.057 0.014
ENSG00000081791 E022 276.903851 0.0017546856 1.071749e-01 2.013642e-01 5 141934258 141934398 141 + 2.365 2.417 0.173
ENSG00000081791 E023 241.946028 0.0007144946 2.171627e-02 5.508726e-02 5 141934494 141934586 93 + 2.296 2.363 0.221
ENSG00000081791 E024 66.329317 0.0005710383 1.410146e-02 3.845627e-02 5 141934587 141934996 410 + 1.862 1.755 -0.363
ENSG00000081791 E025 12.043427 0.0019530533 9.622915e-07 8.010864e-06 5 141937074 141937197 124 + 1.350 0.889 -1.662
ENSG00000081791 E026 265.094677 0.0002360953 1.151506e-04 5.916077e-04 5 141937198 141937357 160 + 2.313 2.411 0.326
ENSG00000081791 E027 363.898300 0.0008830000 6.783840e-04 2.819981e-03 5 141938521 141938760 240 + 2.460 2.545 0.284
ENSG00000081791 E028 82.709025 0.0003566810 2.256307e-01 3.571479e-01 5 141938761 141938851 91 + 1.916 1.870 -0.155
ENSG00000081791 E029 46.144741 0.0005031254 1.947437e-01 3.196798e-01 5 141938852 141938855 4 + 1.583 1.660 0.261
ENSG00000081791 E030 70.618498 0.0005678399 5.887618e-01 7.119296e-01 5 141938856 141938904 49 + 1.834 1.814 -0.068
ENSG00000081791 E031 180.303920 0.0006019855 6.677089e-02 1.380217e-01 5 141938905 141939505 601 + 2.256 2.206 -0.165
ENSG00000081791 E032 68.311929 0.0044255003 8.024377e-01 8.741511e-01 5 141939506 141939509 4 + 1.792 1.811 0.065
ENSG00000081791 E033 114.007298 0.0003033269 6.486347e-02 1.348114e-01 5 141939510 141939553 44 + 1.972 2.043 0.238
ENSG00000081791 E034 644.369869 0.0007185535 2.027718e-05 1.255786e-04 5 141939554 141942047 2494 + 2.711 2.794 0.276
ENSG00000081791 E035 5.450830 0.0030546462 2.966762e-02 7.130910e-02 5 141949332 141949410 79 + 0.515 0.849 1.413
ENSG00000081791 E036 5.301380 0.0032363401 3.500793e-01 4.942540e-01 5 141951426 141951573 148 + 0.666 0.803 0.558