ENSG00000081760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316519 ENSG00000081760 HEK293_OSMI2_2hA HEK293_TMG_2hB AACS protein_coding protein_coding 19.96316 31.44176 14.56984 0.3831511 0.2785249 -1.109166 11.540479 16.969801 8.8728449 1.3053180 0.1985134 -0.9347258 0.60390000 0.54040000 0.60993333 0.06953333 0.58577022 0.01127686 FALSE TRUE
ENST00000539251 ENSG00000081760 HEK293_OSMI2_2hA HEK293_TMG_2hB AACS protein_coding retained_intron 19.96316 31.44176 14.56984 0.3831511 0.2785249 -1.109166 2.788746 7.312029 0.2662477 1.9082842 0.2662477 -4.7282090 0.10370000 0.23170000 0.01766667 -0.21403333 0.03163844 0.01127686 FALSE TRUE
MSTRG.8295.1 ENSG00000081760 HEK293_OSMI2_2hA HEK293_TMG_2hB AACS protein_coding   19.96316 31.44176 14.56984 0.3831511 0.2785249 -1.109166 1.220225 1.721480 0.7188205 0.2658460 0.7188205 -1.2483702 0.05407500 0.05496667 0.04956667 -0.00540000 0.32395699 0.01127686 FALSE TRUE
MSTRG.8295.4 ENSG00000081760 HEK293_OSMI2_2hA HEK293_TMG_2hB AACS protein_coding   19.96316 31.44176 14.56984 0.3831511 0.2785249 -1.109166 1.021314 1.656780 1.0890523 0.2528350 0.4403184 -0.6008038 0.05279583 0.05250000 0.07383333 0.02133333 0.83984669 0.01127686 FALSE TRUE
MSTRG.8295.5 ENSG00000081760 HEK293_OSMI2_2hA HEK293_TMG_2hB AACS protein_coding   19.96316 31.44176 14.56984 0.3831511 0.2785249 -1.109166 1.542403 1.968359 1.5524898 0.2830761 0.2402485 -0.3404576 0.08114167 0.06266667 0.10650000 0.04383333 0.19991297 0.01127686 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081760 E001 1.9489427 0.0072559036 1.890723e-01 3.125747e-01 12 125065431 125065433 3 + 0.581 0.372 -1.054
ENSG00000081760 E002 1.9489427 0.0072559036 1.890723e-01 3.125747e-01 12 125065434 125065434 1 + 0.581 0.372 -1.054
ENSG00000081760 E003 2.2477071 0.0066803070 5.122680e-02 1.113362e-01 12 125065435 125065442 8 + 0.677 0.372 -1.469
ENSG00000081760 E004 9.0041804 0.0701471059 3.820960e-03 1.263893e-02 12 125065443 125065456 14 + 1.216 0.794 -1.568
ENSG00000081760 E005 40.0951552 0.0505897267 2.140855e-01 3.433497e-01 12 125065457 125065475 19 + 1.644 1.535 -0.373
ENSG00000081760 E006 118.1601101 0.0145753929 2.245614e-02 5.663044e-02 12 125065476 125065717 242 + 2.121 1.989 -0.440
ENSG00000081760 E007 125.9484254 0.0012077569 3.175668e-04 1.451052e-03 12 125073876 125073979 104 + 2.134 2.024 -0.367
ENSG00000081760 E008 173.5996292 0.0002494285 1.997267e-05 1.239196e-04 12 125076491 125076611 121 + 2.266 2.166 -0.334
ENSG00000081760 E009 3.1323577 0.0302204887 2.952871e-02 7.103020e-02 12 125078096 125078370 275 + 0.790 0.449 -1.508
ENSG00000081760 E010 179.2345200 0.0002048785 2.925135e-02 7.049281e-02 12 125086330 125086443 114 + 2.238 2.197 -0.136
ENSG00000081760 E011 0.2965864 0.2184664468 5.769153e-01   12 125091013 125091112 100 + 0.000 0.159 16.237
ENSG00000081760 E012 117.2641094 0.0019749860 7.641702e-01 8.473054e-01 12 125091426 125091523 98 + 2.002 2.034 0.110
ENSG00000081760 E013 0.2214452 0.0394700970 1.000000e+00   12 125092480 125092707 228 + 0.000 0.089 15.274
ENSG00000081760 E014 0.3697384 0.0248110999 5.053595e-01 6.411570e-01 12 125100894 125102678 1785 + 0.000 0.162 16.270
ENSG00000081760 E015 117.6984243 0.0045722443 9.425619e-01 9.679502e-01 12 125102679 125102793 115 + 2.012 2.037 0.084
ENSG00000081760 E016 98.8410840 0.0037293179 9.816333e-01 9.925624e-01 12 125103000 125103081 82 + 1.938 1.958 0.067
ENSG00000081760 E017 0.4031496 0.0249097219 5.037639e-01 6.397109e-01 12 125105151 125105794 644 + 0.000 0.162 16.272
ENSG00000081760 E018 133.1399587 0.0016197427 7.061077e-01 8.043315e-01 12 125107121 125107268 148 + 2.074 2.081 0.022
ENSG00000081760 E019 0.1472490 0.0425034249 2.253974e-01   12 125114421 125114476 56 + 0.167 0.000 -17.652
ENSG00000081760 E020 116.6851063 0.0005068737 5.226636e-01 6.564202e-01 12 125114477 125114557 81 + 2.025 2.023 -0.009
ENSG00000081760 E021 0.8126288 0.2176271378 2.234201e-01 3.544714e-01 12 125117567 125118640 1074 + 0.000 0.285 17.309
ENSG00000081760 E022 130.6822752 0.0002297921 9.622161e-01 9.801741e-01 12 125118641 125118765 125 + 2.060 2.079 0.063
ENSG00000081760 E023 18.9615121 0.0031784477 9.530409e-06 6.365938e-05 12 125119858 125124704 4847 + 1.464 1.121 -1.203
ENSG00000081760 E024 97.3341781 0.0003305315 7.144937e-01 8.106816e-01 12 125124705 125124769 65 + 1.922 1.956 0.116
ENSG00000081760 E025 5.2940848 0.0241355010 1.090247e-01 2.041049e-01 12 125124770 125124901 132 + 0.905 0.685 -0.870
ENSG00000081760 E026 129.0364356 0.0002816452 4.588947e-01 5.991350e-01 12 125124902 125125024 123 + 2.037 2.083 0.153
ENSG00000081760 E027 1.5176779 0.0095085908 9.052354e-01 9.436745e-01 12 125125025 125125036 12 + 0.381 0.372 -0.054
ENSG00000081760 E028 23.5974706 0.0147774428 4.630009e-06 3.321876e-05 12 125125742 125128160 2419 + 1.586 1.191 -1.369
ENSG00000081760 E029 139.7745184 0.0002913944 3.360724e-01 4.799029e-01 12 125128161 125128274 114 + 2.068 2.120 0.175
ENSG00000081760 E030 4.0600058 0.2368807650 7.871786e-01 8.636976e-01 12 125128546 125129334 789 + 0.634 0.674 0.171
ENSG00000081760 E031 146.5780939 0.0020822765 7.367948e-01 8.271763e-01 12 125129335 125129460 126 + 2.120 2.128 0.026
ENSG00000081760 E032 128.6361668 0.0004408764 4.868655e-01 6.245782e-01 12 125134003 125134072 70 + 2.037 2.082 0.150
ENSG00000081760 E033 118.5529017 0.0047609156 4.881953e-01 6.257934e-01 12 125134794 125134852 59 + 1.995 2.049 0.181
ENSG00000081760 E034 0.5503986 0.0211753111 9.535633e-01 9.749303e-01 12 125134853 125134853 1 + 0.167 0.162 -0.051
ENSG00000081760 E035 2.2737314 0.0391344499 2.057647e-02 5.270354e-02 12 125135790 125136192 403 + 0.718 0.329 -1.895
ENSG00000081760 E036 206.6489051 0.0002198671 2.210267e-02 5.588784e-02 12 125136662 125136864 203 + 2.212 2.295 0.277
ENSG00000081760 E037 901.0874164 0.0061101395 1.984135e-03 7.177393e-03 12 125142092 125143333 1242 + 2.822 2.942 0.397