ENSG00000081692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480590 ENSG00000081692 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD4 protein_coding retained_intron 65.67002 143.2631 28.65 8.362034 0.6359315 -2.321657 2.852160 4.652393 2.565790 0.7427686 0.6170341 -0.856056 0.05490417 0.03213333 0.08883333 0.05670000 0.02617171 0.0001764768 FALSE  
ENST00000620518 ENSG00000081692 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD4 protein_coding protein_coding 65.67002 143.2631 28.65 8.362034 0.6359315 -2.321657 37.048030 79.738310 13.110705 2.0611497 0.4090791 -2.603609 0.55017917 0.55883333 0.45853333 -0.10030000 0.07485298 0.0001764768 FALSE  
MSTRG.3184.4 ENSG00000081692 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD4 protein_coding   65.67002 143.2631 28.65 8.362034 0.6359315 -2.321657 4.836285 10.322552 2.755095 1.6031267 0.2060160 -1.901796 0.07332500 0.07143333 0.09596667 0.02453333 0.23940083 0.0001764768 FALSE  
MSTRG.3184.7 ENSG00000081692 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD4 protein_coding   65.67002 143.2631 28.65 8.362034 0.6359315 -2.321657 8.348859 22.676440 3.799400 2.0919344 0.4843945 -2.574195 0.11707500 0.15790000 0.13326667 -0.02463333 0.63852742 0.0001764768 FALSE  
MSTRG.3184.8 ENSG00000081692 HEK293_OSMI2_2hA HEK293_TMG_2hB JMJD4 protein_coding   65.67002 143.2631 28.65 8.362034 0.6359315 -2.321657 7.447800 15.430479 3.586331 2.1106795 0.2946461 -2.102120 0.11947917 0.10690000 0.12516667 0.01826667 0.64494646 0.0001764768 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081692 E001 23.096167 8.403971e-04 1.495998e-17 7.162301e-16 1 227730425 227731190 766 - 1.708 1.051 -2.288
ENSG00000081692 E002 15.676834 1.203588e-03 3.678683e-03 1.223453e-02 1 227731191 227731233 43 - 1.303 0.997 -1.096
ENSG00000081692 E003 345.009654 2.186191e-03 1.190296e-01 2.185608e-01 1 227731234 227731464 231 - 2.309 2.361 0.174
ENSG00000081692 E004 328.048922 1.676959e-03 6.251518e-02 1.308769e-01 1 227731465 227731520 56 - 2.279 2.340 0.203
ENSG00000081692 E005 1182.110794 3.758914e-04 1.428940e-01 2.519765e-01 1 227731521 227732143 623 - 2.869 2.889 0.066
ENSG00000081692 E006 178.395907 2.483298e-04 9.714788e-02 1.861171e-01 1 227732144 227732146 3 - 2.012 2.073 0.204
ENSG00000081692 E007 1768.191923 5.904624e-04 8.968800e-08 9.183894e-07 1 227732147 227732676 530 - 2.990 3.071 0.269
ENSG00000081692 E008 647.005517 1.195626e-04 6.898860e-02 1.416983e-01 1 227732881 227732928 48 - 2.595 2.627 0.106
ENSG00000081692 E009 584.446284 1.134175e-04 6.472435e-01 7.589551e-01 1 227732929 227732955 27 - 2.576 2.580 0.012
ENSG00000081692 E010 656.704461 1.316038e-04 6.169587e-01 7.348878e-01 1 227732956 227733027 72 - 2.627 2.631 0.014
ENSG00000081692 E011 49.079578 5.296477e-03 1.087224e-03 4.260184e-03 1 227733028 227733147 120 - 1.715 1.475 -0.817
ENSG00000081692 E012 50.983731 4.886280e-04 4.575589e-04 1.996802e-03 1 227733148 227733303 156 - 1.722 1.493 -0.778
ENSG00000081692 E013 83.419047 5.061783e-04 2.176861e-01 3.476090e-01 1 227733304 227733413 110 - 1.805 1.732 -0.247
ENSG00000081692 E014 1176.434666 1.747016e-04 4.762140e-02 1.049478e-01 1 227733414 227733618 205 - 2.861 2.887 0.085
ENSG00000081692 E015 736.905479 1.131477e-04 5.630940e-01 6.906011e-01 1 227733619 227733681 63 - 2.676 2.681 0.017
ENSG00000081692 E016 7.773648 2.186724e-03 8.006877e-01 8.729678e-01 1 227733682 227733906 225 - 0.817 0.773 -0.175
ENSG00000081692 E017 1077.670487 8.415311e-05 3.523700e-02 8.209834e-02 1 227733907 227734032 126 - 2.878 2.840 -0.127
ENSG00000081692 E018 9.417398 1.841831e-03 7.714443e-02 1.549111e-01 1 227734033 227734377 345 - 1.054 0.819 -0.885
ENSG00000081692 E019 1125.990454 8.810256e-04 2.074316e-05 1.282005e-04 1 227734651 227734816 166 - 2.939 2.854 -0.283
ENSG00000081692 E020 58.612256 1.084249e-02 5.510008e-03 1.731418e-02 1 227734817 227735011 195 - 1.771 1.556 -0.732
ENSG00000081692 E021 880.048912 9.128657e-03 6.951028e-02 1.425453e-01 1 227735012 227735411 400 - 2.832 2.749 -0.275