ENSG00000081377

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-5 / 5
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000375240	ENSG00000081377	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDC14B	protein_coding	protein_coding	8.905993	6.242806	14.89823	0.1070049	0.4721416	1.253533	0.4623319	0.06835988	1.2605570	0.0110730	0.27641688	4.0192022	0.04085417	0.0109000	0.08360000	0.07270000	0.0009547828	0.0001244699	FALSE
ENST00000375241	ENSG00000081377	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDC14B	protein_coding	protein_coding	8.905993	6.242806	14.89823	0.1070049	0.4721416	1.253533	4.6331051	3.65303720	7.5298604	0.2080377	0.29500978	1.0414975	0.52781250	0.5865667	0.50586667	-0.08070000	0.4511380716	0.0001244699	FALSE
ENST00000412285	ENSG00000081377	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDC14B	protein_coding	nonsense_mediated_decay	8.905993	6.242806	14.89823	0.1070049	0.4721416	1.253533	1.6420988	1.21089185	2.4977432	0.1885892	0.45778300	1.0384542	0.19194167	0.1930667	0.16786667	-0.02520000	0.8151257298	0.0001244699	TRUE
ENST00000463569	ENSG00000081377	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDC14B	protein_coding	protein_coding	8.905993	6.242806	14.89823	0.1070049	0.4721416	1.253533	0.5758945	0.12854665	1.2958562	0.0484884	0.02169137	3.2365522	0.05346250	0.0205000	0.08713333	0.06663333	0.0001244699	0.0001244699	FALSE
ENST00000481149	ENSG00000081377	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDC14B	protein_coding	processed_transcript	8.905993	6.242806	14.89823	0.1070049	0.4721416	1.253533	0.7443006	0.84753165	0.9561598	0.1590545	0.08371680	0.1720719	0.09381250	0.1350333	0.06440000	-0.07063333	0.0319967336	0.0001244699

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000081377	E001	22.4180200	0.0014379719	3.342392e-04	1.517279e-03	9	96490241	96493252	3012	-	1.189	1.545	1.238
ENSG00000081377	E002	3.8288990	0.0977882475	1.737582e-01	2.930678e-01	9	96496207	96496359	153	-	0.520	0.877	1.496
ENSG00000081377	E003	0.7373013	0.1563532675	2.612699e-01	3.989056e-01	9	96500108	96500112	5	-	0.141	0.417	2.064
ENSG00000081377	E004	625.6182852	0.0099494904	1.244161e-09	1.810034e-08	9	96500113	96502585	2473	-	2.644	2.947	1.010
ENSG00000081377	E005	29.9868540	0.0101375647	7.538262e-01	8.396298e-01	9	96502586	96502611	26	-	1.434	1.502	0.231
ENSG00000081377	E006	218.1946229	0.0038237242	1.520757e-01	2.645159e-01	9	96502612	96503564	953	-	2.289	2.331	0.137
ENSG00000081377	E007	99.8289220	0.0003305048	7.187702e-05	3.893097e-04	9	96503565	96503789	225	-	1.985	1.924	-0.204
ENSG00000081377	E008	36.1262579	0.0005773435	5.117348e-03	1.624904e-02	9	96509673	96509789	117	-	1.559	1.471	-0.303
ENSG00000081377	E009	7.3557837	0.0024154054	3.988947e-03	1.311182e-02	9	96514216	96514369	154	-	0.959	0.633	-1.295
ENSG00000081377	E010	12.1534213	0.0022565618	2.054200e-05	1.270899e-04	9	96514503	96514949	447	-	0.878	1.371	1.781
ENSG00000081377	E011	39.2088435	0.0038626521	3.382022e-02	7.939651e-02	9	96515649	96515792	144	-	1.586	1.537	-0.169
ENSG00000081377	E012	86.0272372	0.0003251078	1.486140e-06	1.189609e-05	9	96522506	96522603	98	-	1.933	1.822	-0.374
ENSG00000081377	E013	103.6992849	0.0002789303	3.693444e-05	2.146422e-04	9	96523261	96523420	160	-	1.999	1.936	-0.214
ENSG00000081377	E014	71.0699635	0.0003471839	9.012483e-05	4.755955e-04	9	96523587	96523725	139	-	1.845	1.756	-0.299
ENSG00000081377	E015	47.5264864	0.0005051302	1.497341e-01	2.613140e-01	9	96533927	96534000	74	-	1.645	1.658	0.045
ENSG00000081377	E016	67.6796365	0.0004089036	2.466459e-01	3.820195e-01	9	96534001	96534140	140	-	1.786	1.826	0.134
ENSG00000081377	E017	37.7668762	0.0005919461	3.933236e-01	5.372196e-01	9	96534141	96534157	17	-	1.538	1.578	0.136
ENSG00000081377	E018	63.2607900	0.0007579941	5.120276e-02	1.112945e-01	9	96534455	96534542	88	-	1.771	1.769	-0.007
ENSG00000081377	E019	0.1482932	0.0414419474	2.112271e-01		9	96538627	96538725	99	-	0.000	0.190	11.130
ENSG00000081377	E020	0.6621601	0.0165593554	4.163464e-01	5.597253e-01	9	96538975	96539077	103	-	0.142	0.322	1.513
ENSG00000081377	E021	49.6733233	0.0004846965	8.401381e-02	1.658260e-01	9	96539078	96539140	63	-	1.669	1.669	-0.002
ENSG00000081377	E022	50.1512318	0.0004660485	3.654853e-03	1.216916e-02	9	96541826	96541892	67	-	1.692	1.625	-0.225
ENSG00000081377	E023	29.3720245	0.0007055119	1.034791e-03	4.078857e-03	9	96551796	96551800	5	-	1.487	1.340	-0.507
ENSG00000081377	E024	46.5187091	0.0005070134	2.508704e-03	8.789347e-03	9	96551801	96551872	72	-	1.664	1.584	-0.271
ENSG00000081377	E025	0.1451727	0.0428869602	1.000000e+00		9	96562548	96562692	145	-	0.077	0.000	-8.383
ENSG00000081377	E026	44.7329009	0.0007792174	3.866502e-02	8.856211e-02	9	96562693	96562785	93	-	1.630	1.602	-0.093
ENSG00000081377	E027	40.0857295	0.0006145332	2.203737e-02	5.575621e-02	9	96564777	96564852	76	-	1.586	1.538	-0.164
ENSG00000081377	E028	32.8191378	0.0007999792	2.298111e-02	5.770926e-02	9	96565393	96565455	63	-	1.508	1.446	-0.213
ENSG00000081377	E029	22.6475696	0.0009930587	8.466518e-03	2.495226e-02	9	96565456	96565483	28	-	1.368	1.243	-0.438
ENSG00000081377	E030	0.4355181	0.5767287532	5.785148e-01	7.035970e-01	9	96565484	96565512	29	-	0.197	0.000	-9.958
ENSG00000081377	E031	0.5922303	0.0180017387	8.266337e-01	8.909138e-01	9	96566768	96567254	487	-	0.198	0.190	-0.074
ENSG00000081377	E032	0.6653823	0.0170399508	8.290508e-01	8.926287e-01	9	96618495	96618743	249	-	0.198	0.190	-0.071
ENSG00000081377	E033	27.7558698	0.0007028165	6.372017e-05	3.496480e-04	9	96619219	96619843	625	-	1.473	1.256	-0.752

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000081377

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3