ENSG00000081307

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356232 ENSG00000081307 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA5 protein_coding protein_coding 44.47096 19.44932 70.04642 1.305597 2.061076 1.848056 3.789564 1.9479645 6.708266 0.2348349 0.2521366 1.778734 0.08277083 0.10053333 0.09576667 -0.004766667 0.92841645 1.727443e-05 FALSE TRUE
ENST00000464101 ENSG00000081307 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA5 protein_coding retained_intron 44.47096 19.44932 70.04642 1.305597 2.061076 1.848056 10.935577 3.6078370 20.595863 0.4262142 0.8362066 2.509856 0.23770833 0.18563333 0.29450000 0.108866667 0.01308916 1.727443e-05 FALSE FALSE
ENST00000473651 ENSG00000081307 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA5 protein_coding protein_coding 44.47096 19.44932 70.04642 1.305597 2.061076 1.848056 2.566510 0.6292958 4.559724 0.6292958 0.1317703 2.837552 0.05007500 0.02853333 0.06523333 0.036700000 0.20757737 1.727443e-05 FALSE TRUE
MSTRG.23731.15 ENSG00000081307 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA5 protein_coding   44.47096 19.44932 70.04642 1.305597 2.061076 1.848056 20.185067 10.3710782 31.002532 0.8570264 1.8468807 1.578895 0.46564583 0.53313333 0.44186667 -0.091266667 0.10426977 1.727443e-05 FALSE TRUE
MSTRG.23731.9 ENSG00000081307 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA5 protein_coding   44.47096 19.44932 70.04642 1.305597 2.061076 1.848056 1.822494 1.4810713 0.000000 0.7572203 0.0000000 -7.220205 0.05250833 0.08156667 0.00000000 -0.081566667 0.07062219 1.727443e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081307 E001 0.000000       3 132654446 132654670 225 +      
ENSG00000081307 E002 1.537362 0.0326356345 6.802645e-01 7.841968e-01 3 132659885 132659891 7 + 0.406 0.321 -0.497
ENSG00000081307 E003 1.687732 0.0132460998 9.202999e-01 9.536596e-01 3 132659892 132659917 26 + 0.406 0.422 0.086
ENSG00000081307 E004 2.426167 0.0385739956 5.338262e-01 6.659628e-01 3 132659918 132659945 28 + 0.546 0.422 -0.615
ENSG00000081307 E005 11.179347 0.0015666971 3.178955e-01 4.608054e-01 3 132659946 132660050 105 + 1.080 0.964 -0.424
ENSG00000081307 E006 15.112145 0.0011508436 6.164532e-01 7.345028e-01 3 132660051 132660184 134 + 1.185 1.133 -0.185
ENSG00000081307 E007 17.217159 0.0082154688 6.726256e-01 7.785265e-01 3 132660185 132660304 120 + 1.232 1.184 -0.168
ENSG00000081307 E008 7.296384 0.1139988892 8.676953e-01 9.188934e-01 3 132660305 132660309 5 + 0.892 0.854 -0.146
ENSG00000081307 E009 8.893521 0.0298339561 5.314633e-01 6.639026e-01 3 132660310 132660328 19 + 0.979 0.883 -0.361
ENSG00000081307 E010 16.145792 0.0032353055 2.072281e-01 3.352068e-01 3 132660329 132660342 14 + 1.227 1.097 -0.461
ENSG00000081307 E011 33.441256 0.0020774392 3.698618e-03 1.229241e-02 3 132660343 132660359 17 + 1.549 1.328 -0.762
ENSG00000081307 E012 34.231098 0.0006726958 7.130511e-03 2.156329e-02 3 132660360 132660361 2 + 1.554 1.360 -0.668
ENSG00000081307 E013 83.889912 0.0004464887 1.352036e-06 1.091812e-05 3 132660362 132660395 34 + 1.946 1.716 -0.776
ENSG00000081307 E014 107.226715 0.0010550960 7.343730e-08 7.654311e-07 3 132660396 132660426 31 + 2.053 1.814 -0.804
ENSG00000081307 E015 124.122169 0.0004671490 2.132710e-08 2.473889e-07 3 132660427 132660477 51 + 2.112 1.890 -0.743
ENSG00000081307 E016 91.657110 0.0035287348 2.692035e-05 1.619510e-04 3 132660478 132660488 11 + 1.982 1.757 -0.759
ENSG00000081307 E017 160.019941 0.0060929335 2.663150e-03 9.262113e-03 3 132660489 132660600 112 + 2.206 2.055 -0.508
ENSG00000081307 E018 137.312648 0.0008239625 8.907295e-02 1.737115e-01 3 132660601 132660696 96 + 2.120 2.054 -0.219
ENSG00000081307 E019 66.693127 0.0003811429 9.804447e-01 9.917660e-01 3 132660697 132660698 2 + 1.793 1.791 -0.008
ENSG00000081307 E020 7.583359 0.0021664773 1.590875e-02 4.252968e-02 3 132660699 132660898 200 + 0.978 0.632 -1.373
ENSG00000081307 E021 6.718288 0.0024234317 1.423680e-02 3.876340e-02 3 132660899 132661048 150 + 0.941 0.572 -1.499
ENSG00000081307 E022 3.298349 0.0766375911 9.600288e-02 1.843740e-01 3 132661216 132661257 42 + 0.686 0.322 -1.814
ENSG00000081307 E023 4.605267 0.0036615081 3.030379e-02 7.256586e-02 3 132665739 132665822 84 + 0.794 0.422 -1.668
ENSG00000081307 E024 102.074196 0.0002929785 9.900334e-01 9.978570e-01 3 132665823 132665868 46 + 1.975 1.971 -0.013
ENSG00000081307 E025 154.244941 0.0002603023 1.208075e-01 2.211053e-01 3 132665984 132666073 90 + 2.140 2.185 0.150
ENSG00000081307 E026 8.195387 0.0020064272 7.280080e-05 3.936492e-04 3 132666074 132666151 78 + 1.044 0.422 -2.614
ENSG00000081307 E027 51.628233 0.0004615541 5.756742e-10 8.926885e-09 3 132667258 132668817 1560 + 1.767 1.370 -1.355
ENSG00000081307 E028 216.653641 0.0037771255 3.484377e-01 4.926743e-01 3 132668818 132668927 110 + 2.289 2.322 0.112
ENSG00000081307 E029 221.323290 0.0002016277 6.599767e-01 7.686999e-01 3 132670198 132670284 87 + 2.313 2.298 -0.050
ENSG00000081307 E030 1.036167 0.0117526327 4.598137e-01 5.999031e-01 3 132670682 132670964 283 + 0.335 0.190 -1.085
ENSG00000081307 E031 251.648069 0.0001963966 2.363713e-01 3.699559e-01 3 132670965 132671049 85 + 2.373 2.340 -0.110
ENSG00000081307 E032 241.974375 0.0001994647 8.236479e-01 8.888956e-01 3 132671777 132671881 105 + 2.348 2.350 0.008
ENSG00000081307 E033 2.114063 0.0568874015 8.600836e-01 9.137553e-01 3 132671882 132672049 168 + 0.468 0.501 0.165
ENSG00000081307 E034 236.078531 0.0001860660 5.016293e-04 2.165926e-03 3 132672050 132672177 128 + 2.311 2.393 0.276
ENSG00000081307 E035 257.374903 0.0001827296 3.271339e-08 3.657178e-07 3 132675248 132675381 134 + 2.333 2.459 0.421
ENSG00000081307 E036 130.341261 0.0004979477 4.183839e-08 4.584774e-07 3 132675382 132675383 2 + 2.021 2.200 0.602
ENSG00000081307 E037 2.775407 0.0335924959 8.687213e-01 9.196178e-01 3 132675384 132675604 221 + 0.546 0.572 0.118
ENSG00000081307 E038 215.757305 0.0009125802 7.828014e-08 8.114507e-07 3 132675605 132675680 76 + 2.249 2.399 0.500
ENSG00000081307 E039 207.767031 0.0002569036 5.855942e-11 1.073846e-09 3 132675817 132675923 107 + 2.226 2.393 0.560
ENSG00000081307 E040 317.719580 0.0001865038 1.714712e-02 4.526727e-02 3 132676443 132676854 412 + 2.450 2.498 0.160
ENSG00000081307 E041 407.030738 0.0011443730 2.913525e-02 7.026039e-02 3 132676855 132679794 2940 + 2.589 2.534 -0.181