ENSG00000081189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424173 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.16555473 0.23115159 0.1923126 0.08216038 0.1025549 -0.2533538 0.08162917 0.21526667 0.07026667 -0.14500000 0.4708212417 0.0008758818 FALSE TRUE
ENST00000502983 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.02420682 0.07061307 0.0000000 0.07061307 0.0000000 -3.0110137 0.01308333 0.05900000 0.00000000 -0.05900000 0.4917848811 0.0008758818 FALSE FALSE
ENST00000503955 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding retained_intron 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.14847605 0.00000000 0.4014579 0.00000000 0.4014579 5.3626729 0.08336667 0.00000000 0.09930000 0.09930000 0.9664603942 0.0008758818   FALSE
ENST00000508569 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.22675908 0.00000000 0.5730664 0.00000000 0.1501863 5.8655883 0.05480417 0.00000000 0.18590000 0.18590000 0.0008758818 0.0008758818 FALSE TRUE
ENST00000510942 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.23859754 0.20706154 0.5517731 0.11788755 0.1827851 1.3718834 0.10537500 0.19740000 0.16616667 -0.03123333 0.9852762079 0.0008758818 FALSE TRUE
ENST00000627717 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.17683798 0.11749844 0.1527878 0.07445028 0.0932819 0.3525130 0.05032500 0.11373333 0.04890000 -0.06483333 0.7834692905 0.0008758818 FALSE TRUE
ENST00000636998 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.28078065 0.25458490 0.2734592 0.12793718 0.2734592 0.0994106 0.11042917 0.22526667 0.10616667 -0.11910000 0.4972493591 0.0008758818 FALSE TRUE
ENST00000637481 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding protein_coding 2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.48821844 0.07296751 0.4554173 0.07296751 0.2311172 2.4879066 0.18051667 0.06096667 0.13383333 0.07286667 0.7535188813 0.0008758818 FALSE TRUE
MSTRG.26568.10 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding   2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.34593387 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000 0.10460417 0.00000000 0.00000000 0.00000000   0.0008758818 FALSE TRUE
MSTRG.26568.23 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding   2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.40971493 0.05571513 0.2625160 0.05571513 0.2625160 2.0520433 0.09710000 0.05453333 0.09206667 0.03753333 0.9182127293 0.0008758818 FALSE TRUE
MSTRG.26568.26 ENSG00000081189 HEK293_OSMI2_2hA HEK293_TMG_2hB MEF2C protein_coding   2.795248 1.09404 3.156447 0.05272561 0.4500731 1.520073 0.02196230 0.00000000 0.1756984 0.00000000 0.1756984 4.2148892 0.00852500 0.00000000 0.06820000 0.06820000 1.0000000000 0.0008758818 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081189 E001 0.1515154 0.042739859 1.000000e+00   5 88717117 88718240 1124 - 0.083 0.000 -9.985
ENSG00000081189 E002 1.0319116 0.013445620 6.576136e-02 1.363052e-01 5 88718241 88718273 33 - 0.153 0.479 2.258
ENSG00000081189 E003 45.2089595 0.007050466 1.256574e-08 1.521405e-07 5 88718274 88720025 1752 - 1.493 1.852 1.220
ENSG00000081189 E004 8.6315727 0.008592873 7.919579e-02 1.582270e-01 5 88720026 88720336 311 - 0.888 1.098 0.776
ENSG00000081189 E005 9.4482204 0.002149454 8.366034e-01 8.978191e-01 5 88720337 88720824 488 - 0.993 1.023 0.112
ENSG00000081189 E006 1.1886253 0.013432311 2.492428e-01 3.850186e-01 5 88720825 88720828 4 - 0.265 0.478 1.252
ENSG00000081189 E007 2.2926317 0.007031661 1.216541e-01 2.222959e-01 5 88720829 88720843 15 - 0.393 0.655 1.257
ENSG00000081189 E008 2.8032894 0.005766331 5.052496e-02 1.100928e-01 5 88720844 88720855 12 - 0.429 0.743 1.427
ENSG00000081189 E009 30.7937504 0.007283150 2.743482e-06 2.072016e-05 5 88720856 88721569 714 - 1.335 1.677 1.174
ENSG00000081189 E010 2.4365712 0.147679660 1.968447e-01 3.222938e-01 5 88721570 88721576 7 - 0.393 0.728 1.564
ENSG00000081189 E011 2.5085774 0.241464626 1.337849e-01 2.394146e-01 5 88721577 88721619 43 - 0.354 0.765 1.937
ENSG00000081189 E012 1.6240271 0.035675733 1.489965e-02 4.025978e-02 5 88721620 88721646 27 - 0.213 0.654 2.473
ENSG00000081189 E013 7.0177796 0.011324527 2.084736e-04 1.000296e-03 5 88721647 88721924 278 - 0.661 1.133 1.813
ENSG00000081189 E014 19.4886699 0.058652707 9.885093e-01 9.968706e-01 5 88721925 88722488 564 - 1.281 1.283 0.006
ENSG00000081189 E015 3.3999817 0.004475114 1.091553e-04 5.641868e-04 5 88722489 88722494 6 - 0.766 0.000 -16.271
ENSG00000081189 E016 3.2421235 0.004838476 1.597743e-04 7.908647e-04 5 88722495 88722497 3 - 0.751 0.000 -16.231
ENSG00000081189 E017 5.6509005 0.002819122 1.368362e-04 6.895204e-04 5 88722498 88722566 69 - 0.933 0.302 -2.913
ENSG00000081189 E018 4.7899930 0.003363749 2.078559e-02 5.313696e-02 5 88722567 88722600 34 - 0.838 0.479 -1.551
ENSG00000081189 E019 4.3953867 0.003879743 1.209070e-01 2.212447e-01 5 88722601 88722603 3 - 0.782 0.546 -1.006
ENSG00000081189 E020 10.1372078 0.002035620 5.147763e-04 2.214717e-03 5 88722604 88722729 126 - 1.128 0.701 -1.626
ENSG00000081189 E021 11.4489417 0.001589764 1.534606e-02 4.127351e-02 5 88722730 88722827 98 - 1.141 0.878 -0.973
ENSG00000081189 E022 6.7268062 0.002509286 1.176310e-02 3.296622e-02 5 88722828 88722829 2 - 0.954 0.604 -1.406
ENSG00000081189 E023 3.8386203 0.004152634 6.923066e-04 2.871115e-03 5 88722830 88722836 7 - 0.797 0.177 -3.387
ENSG00000081189 E024 3.2601196 0.004766289 2.635443e-03 9.176194e-03 5 88722837 88722852 16 - 0.734 0.177 -3.136
ENSG00000081189 E025 2.5141957 0.006067682 7.719922e-02 1.550016e-01 5 88722853 88722865 13 - 0.619 0.302 -1.651
ENSG00000081189 E026 3.3988478 0.004489136 5.793428e-02 1.230945e-01 5 88722866 88722925 60 - 0.717 0.399 -1.481
ENSG00000081189 E027 13.3862325 0.001350883 2.836007e-02 6.872785e-02 5 88728493 88728628 136 - 1.197 0.980 -0.785
ENSG00000081189 E028 14.5911630 0.075784804 6.433186e-01 7.559111e-01 5 88729218 88729347 130 - 1.195 1.106 -0.320
ENSG00000081189 E029 0.0000000       5 88729348 88729519 172 -      
ENSG00000081189 E030 0.0000000       5 88730211 88730234 24 -      
ENSG00000081189 E031 0.3729606 0.027287864 5.272432e-01 6.603667e-01 5 88731437 88731728 292 - 0.083 0.177 1.260
ENSG00000081189 E032 10.5523939 0.069123070 5.868553e-01 7.103070e-01 5 88731729 88731804 76 - 1.068 0.963 -0.386
ENSG00000081189 E033 8.2160044 0.005096353 2.957035e-01 4.368520e-01 5 88731805 88731851 47 - 0.974 0.848 -0.477
ENSG00000081189 E034 9.5205674 0.001976627 7.588212e-01 8.433298e-01 5 88731852 88731901 50 - 0.984 1.024 0.148
ENSG00000081189 E035 0.0000000       5 88732472 88732543 72 -      
ENSG00000081189 E036 6.0119368 0.012073514 3.738289e-01 5.182488e-01 5 88749070 88749085 16 - 0.782 0.905 0.478
ENSG00000081189 E037 6.6321660 0.055820389 3.513068e-01 4.955269e-01 5 88749086 88749117 32 - 0.811 0.955 0.550
ENSG00000081189 E038 0.0000000       5 88749118 88749124 7 -      
ENSG00000081189 E039 5.3120991 0.024549798 5.302135e-01 6.628588e-01 5 88751857 88751861 5 - 0.751 0.846 0.378
ENSG00000081189 E040 4.7166465 0.042992795 3.047291e-01 4.467610e-01 5 88751862 88751865 4 - 0.680 0.845 0.664
ENSG00000081189 E041 13.6243505 0.001412269 5.899825e-01 7.129551e-01 5 88751866 88752043 178 - 1.161 1.116 -0.158
ENSG00000081189 E042 0.2214452 0.039533372 2.015069e-01   5 88760988 88761022 35 - 0.000 0.177 13.545
ENSG00000081189 E043 0.9525055 0.015457086 8.561503e-01 9.110603e-01 5 88761023 88761125 103 - 0.265 0.302 0.258
ENSG00000081189 E044 5.5787901 0.002943480 5.558654e-02 1.189816e-01 5 88761185 88761199 15 - 0.877 0.604 -1.113
ENSG00000081189 E045 4.4069131 0.003724852 2.647377e-01 4.027218e-01 5 88761200 88761208 9 - 0.767 0.604 -0.682
ENSG00000081189 E046 4.5626950 0.004114479 2.220369e-01 3.528463e-01 5 88761209 88761216 8 - 0.782 0.604 -0.744
ENSG00000081189 E047 7.8603733 0.007614502 5.611464e-01 6.890199e-01 5 88761217 88761268 52 - 0.944 0.877 -0.252
ENSG00000081189 E048 7.1468059 0.002328629 2.156228e-01 3.451620e-01 5 88761269 88761309 41 - 0.933 0.780 -0.591
ENSG00000081189 E049 5.4148517 0.024014428 5.940409e-01 7.163316e-01 5 88761310 88761324 15 - 0.811 0.741 -0.279
ENSG00000081189 E050 4.1509980 0.004360125 1.802487e-01 3.014920e-01 5 88761325 88761328 4 - 0.751 0.546 -0.881
ENSG00000081189 E051 0.0000000       5 88761718 88761912 195 -      
ENSG00000081189 E052 0.0000000       5 88771779 88771788 10 -      
ENSG00000081189 E053 0.0000000       5 88771789 88771866 78 -      
ENSG00000081189 E054 0.0000000       5 88771973 88772000 28 -      
ENSG00000081189 E055 0.0000000       5 88772266 88772281 16 -      
ENSG00000081189 E056 0.0000000       5 88772282 88772361 80 -      
ENSG00000081189 E057 0.0000000       5 88785339 88785542 204 -      
ENSG00000081189 E058 0.0000000       5 88804526 88804597 72 -      
ENSG00000081189 E059 13.0199923 0.001397294 6.898144e-02 1.416873e-01 5 88804598 88804753 156 - 1.179 1.002 -0.640
ENSG00000081189 E060 5.5496438 0.002954308 1.572408e-01 2.714266e-01 5 88804754 88804769 16 - 0.852 0.655 -0.794
ENSG00000081189 E061 6.9617787 0.002972543 2.518550e-01 3.881483e-01 5 88804770 88804801 32 - 0.923 0.780 -0.551
ENSG00000081189 E062 0.0000000       5 88817805 88817831 27 -      
ENSG00000081189 E063 8.1562411 0.009016755 5.795221e-01 7.044231e-01 5 88823735 88823795 61 - 0.964 0.905 -0.223
ENSG00000081189 E064 8.6893768 0.001954080 6.083436e-01 7.281053e-01 5 88823796 88823860 65 - 0.984 0.932 -0.194
ENSG00000081189 E065 4.4759111 0.005282343 5.797009e-01 7.045374e-01 5 88823861 88823862 2 - 0.734 0.656 -0.326
ENSG00000081189 E066 6.9921936 0.007322667 7.303692e-01 8.223522e-01 5 88823863 88823900 38 - 0.889 0.848 -0.156
ENSG00000081189 E067 7.5854576 0.002304619 2.456274e-01 3.807968e-01 5 88823901 88823927 27 - 0.954 0.815 -0.532
ENSG00000081189 E068 3.4062452 0.004942629 8.482005e-01 9.057473e-01 5 88823928 88823930 3 - 0.619 0.655 0.156
ENSG00000081189 E069 0.1515154 0.042739859 1.000000e+00   5 88823931 88824275 345 - 0.083 0.000 -12.771
ENSG00000081189 E070 0.0000000       5 88824278 88824309 32 -      
ENSG00000081189 E071 0.0000000       5 88824310 88824340 31 -      
ENSG00000081189 E072 0.0000000       5 88824880 88824914 35 -      
ENSG00000081189 E073 0.1515154 0.042739859 1.000000e+00   5 88825719 88825864 146 - 0.083 0.000 -12.771
ENSG00000081189 E074 0.0000000       5 88827036 88827192 157 -      
ENSG00000081189 E075 0.0000000       5 88839240 88839378 139 -      
ENSG00000081189 E076 0.0000000       5 88839379 88839623 245 -      
ENSG00000081189 E077 0.0000000       5 88877938 88877941 4 -      
ENSG00000081189 E078 0.0000000       5 88877942 88877962 21 -      
ENSG00000081189 E079 0.0000000       5 88877963 88878020 58 -      
ENSG00000081189 E080 0.0000000       5 88880844 88880923 80 -      
ENSG00000081189 E081 0.1482932 0.041159753 2.044945e-01   5 88880924 88880981 58 - 0.000 0.177 13.535
ENSG00000081189 E082 0.3697384 0.027442404 5.374560e-02 1.158065e-01 5 88880982 88881022 41 - 0.000 0.302 14.486
ENSG00000081189 E083 0.0000000       5 88881023 88881264 242 -      
ENSG00000081189 E084 6.4194309 0.002633630 6.710281e-01 7.773677e-01 5 88882955 88882959 5 - 0.864 0.815 -0.190
ENSG00000081189 E085 8.2190376 0.002193989 5.807693e-01 7.054649e-01 5 88882960 88882999 40 - 0.964 0.905 -0.221
ENSG00000081189 E086 6.5980256 0.014673342 4.516868e-01 5.926155e-01 5 88883000 88883048 49 - 0.825 0.931 0.407
ENSG00000081189 E087 10.0021705 0.001760997 7.592359e-01 8.436316e-01 5 88883049 88883466 418 - 1.029 1.002 -0.097
ENSG00000081189 E088 0.2998086 0.028008614 5.321521e-01   5 88883652 88883747 96 - 0.083 0.177 1.254
ENSG00000081189 E089 0.0000000       5 88884328 88884355 28 -      
ENSG00000081189 E090 0.0000000       5 88884356 88884426 71 -      
ENSG00000081189 E091 0.1482932 0.041159753 2.044945e-01   5 88884489 88884568 80 - 0.000 0.177 13.535
ENSG00000081189 E092 0.0000000       5 88887392 88887501 110 -      
ENSG00000081189 E093 0.0000000       5 88887502 88887542 41 -      
ENSG00000081189 E094 0.0000000       5 88887543 88887564 22 -      
ENSG00000081189 E095 0.0000000       5 88887565 88887584 20 -      
ENSG00000081189 E096 0.0000000       5 88887585 88887598 14 -      
ENSG00000081189 E097 0.0000000       5 88888167 88888232 66 -      
ENSG00000081189 E098 0.0000000       5 88888879 88888888 10 -      
ENSG00000081189 E099 0.0000000       5 88888889 88889050 162 -      
ENSG00000081189 E100 0.1515154 0.042739859 1.000000e+00   5 88889051 88889324 274 - 0.083 0.000 -12.771
ENSG00000081189 E101 0.0000000       5 88903916 88904257 342 -