ENSG00000081059

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342854 ENSG00000081059 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7 protein_coding protein_coding 6.483285 9.212695 6.835779 0.4136394 0.08080159 -0.4299736 0.8715501 0.3987339 2.4487821 0.2478370 0.5417629 2.588710 0.12095417 0.04203333 0.36000000 0.31796667 0.003622508 0.0006588964 FALSE TRUE
ENST00000395023 ENSG00000081059 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7 protein_coding protein_coding 6.483285 9.212695 6.835779 0.4136394 0.08080159 -0.4299736 3.7965394 6.5622678 2.5475797 0.3013051 1.2743243 -1.361612 0.58763750 0.71296667 0.36846667 -0.34450000 0.589788130 0.0006588964 FALSE TRUE
ENST00000517855 ENSG00000081059 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7 protein_coding protein_coding 6.483285 9.212695 6.835779 0.4136394 0.08080159 -0.4299736 0.1792727 0.0000000 0.4864298 0.0000000 0.4864298 5.633518 0.03237917 0.00000000 0.07283333 0.07283333 0.805087062 0.0006588964 FALSE TRUE
MSTRG.26933.3 ENSG00000081059 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7 protein_coding   6.483285 9.212695 6.835779 0.4136394 0.08080159 -0.4299736 1.0358462 1.5832121 0.6890815 0.2640742 0.1725372 -1.188406 0.16080833 0.16990000 0.10140000 -0.06850000 0.295246263 0.0006588964 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081059 E001 0.9180632 0.0133952364 3.734492e-02 8.611837e-02 5 134114681 134114711 31 + 0.469 0.104 -2.840
ENSG00000081059 E002 6.1249129 0.0035569874 7.919975e-12 1.675319e-10 5 134114712 134114864 153 + 1.199 0.259 -4.182
ENSG00000081059 E003 21.0842791 0.0836249266 5.733640e-03 1.790996e-02 5 134114865 134115155 291 + 1.542 1.124 -1.461
ENSG00000081059 E004 0.1482932 0.0414445738 6.596896e-01   5 134115201 134115320 120 + 0.000 0.104 11.283
ENSG00000081059 E005 13.2768580 0.0363979421 2.616654e-01 3.993347e-01 5 134115321 134115351 31 + 1.220 1.079 -0.503
ENSG00000081059 E006 15.0932884 0.0364677803 1.759420e-01 2.959254e-01 5 134115352 134115387 36 + 1.286 1.118 -0.596
ENSG00000081059 E007 0.1482932 0.0414445738 6.596896e-01   5 134115563 134115606 44 + 0.000 0.104 11.283
ENSG00000081059 E008 0.1482932 0.0414445738 6.596896e-01   5 134115607 134115609 3 + 0.000 0.104 11.283
ENSG00000081059 E009 0.1482932 0.0414445738 6.596896e-01   5 134115610 134115624 15 + 0.000 0.104 11.283
ENSG00000081059 E010 0.1482932 0.0414445738 6.596896e-01   5 134115625 134115630 6 + 0.000 0.104 11.283
ENSG00000081059 E011 0.1482932 0.0414445738 6.596896e-01   5 134115631 134115640 10 + 0.000 0.104 11.283
ENSG00000081059 E012 0.0000000       5 134115641 134115658 18 +      
ENSG00000081059 E013 0.0000000       5 134115659 134115674 16 +      
ENSG00000081059 E014 0.1482932 0.0414445738 6.596896e-01   5 134115675 134115908 234 + 0.000 0.104 11.283
ENSG00000081059 E015 13.6538696 0.0397984160 4.500214e-01 5.911996e-01 5 134115909 134115910 2 + 1.209 1.108 -0.364
ENSG00000081059 E016 19.5497340 0.0145620265 4.351296e-01 5.773619e-01 5 134115911 134115955 45 + 1.343 1.261 -0.287
ENSG00000081059 E017 20.0127208 0.0009608701 9.318524e-01 9.610626e-01 5 134115956 134116033 78 + 1.303 1.302 -0.004
ENSG00000081059 E018 0.2214452 0.0379445393 6.577381e-01   5 134116034 134116086 53 + 0.000 0.105 11.305
ENSG00000081059 E019 0.4783925 0.0221278259 3.884121e-01 5.324846e-01 5 134123618 134123756 139 + 0.250 0.104 -1.519
ENSG00000081059 E020 1.3693847 0.0104329166 8.164209e-01 8.838401e-01 5 134137865 134138058 194 + 0.336 0.373 0.218
ENSG00000081059 E021 16.9925481 0.0055695047 4.805276e-01 6.188062e-01 5 134138059 134138103 45 + 1.286 1.217 -0.244
ENSG00000081059 E022 25.9328778 0.0010351575 9.717726e-01 9.863771e-01 5 134138104 134138164 61 + 1.420 1.415 -0.018
ENSG00000081059 E023 0.1482932 0.0414445738 6.596896e-01   5 134138165 134138237 73 + 0.000 0.104 11.283
ENSG00000081059 E024 0.1515154 0.0423012199 3.548001e-01   5 134138601 134138950 350 + 0.143 0.000 -12.828
ENSG00000081059 E025 39.8647630 0.0006565624 1.815418e-01 3.031650e-01 5 134138951 134139038 88 + 1.548 1.615 0.232
ENSG00000081059 E026 0.8115846 0.5390537742 7.296900e-01 8.218302e-01 5 134139039 134139858 820 + 0.143 0.275 1.182
ENSG00000081059 E027 0.0000000       5 134140535 134140795 261 +      
ENSG00000081059 E028 2.0240693 0.0072350545 5.634109e-01 6.908762e-01 5 134140796 134140888 93 + 0.408 0.502 0.481
ENSG00000081059 E029 0.5900403 0.4637872677 3.821323e-01 5.263624e-01 5 134141021 134141350 330 + 0.336 0.102 -2.136
ENSG00000081059 E030 1.0748747 0.0140108499 6.833279e-01 7.865651e-01 5 134141464 134142184 721 + 0.336 0.259 -0.516
ENSG00000081059 E031 30.9318576 0.0007172087 6.454993e-01 7.575944e-01 5 134142185 134142215 31 + 1.469 1.490 0.073
ENSG00000081059 E032 53.6245944 0.0004671922 9.446465e-01 9.692503e-01 5 134142216 134142304 89 + 1.720 1.715 -0.016
ENSG00000081059 E033 59.1787831 0.0004619887 1.608762e-01 2.762596e-01 5 134142721 134142791 71 + 1.804 1.733 -0.242
ENSG00000081059 E034 65.1589749 0.0003742045 1.466013e-01 2.570638e-01 5 134142792 134142883 92 + 1.845 1.774 -0.238
ENSG00000081059 E035 0.0000000       5 134142884 134142992 109 +      
ENSG00000081059 E036 59.9400239 0.0004580216 5.927470e-01 7.152370e-01 5 134142993 134143100 108 + 1.788 1.756 -0.108
ENSG00000081059 E037 0.1472490 0.0425811729 3.545825e-01   5 134143101 134143477 377 + 0.143 0.000 -12.826
ENSG00000081059 E038 46.1516200 0.0005925909 3.197663e-01 4.628558e-01 5 134143592 134143640 49 + 1.622 1.667 0.152
ENSG00000081059 E039 3.1837533 0.0052785570 1.026311e-01 1.945152e-01 5 134143641 134144796 1156 + 0.754 0.502 -1.105
ENSG00000081059 E040 2.3259557 0.0410582642 6.858622e-01 7.884903e-01 5 134144797 134144869 73 + 0.571 0.499 -0.340
ENSG00000081059 E041 2.3122377 0.0815726547 9.282572e-01 9.588477e-01 5 134144870 134145259 390 + 0.523 0.502 -0.102
ENSG00000081059 E042 0.6589510 0.0195314710 4.963109e-01 6.330054e-01 5 134145260 134145340 81 + 0.143 0.259 1.065
ENSG00000081059 E043 2.0679773 0.0073380816 7.394777e-01 8.291611e-01 5 134145341 134145740 400 + 0.523 0.463 -0.298
ENSG00000081059 E044 3.1530572 0.1237577026 3.314306e-01 4.750409e-01 5 134145741 134146200 460 + 0.722 0.507 -0.946
ENSG00000081059 E045 4.5725884 0.0135152834 6.532374e-01 7.637619e-01 5 134146201 134146223 23 + 0.690 0.750 0.248
ENSG00000081059 E046 29.0912502 0.0104565902 5.813869e-01 7.059208e-01 5 134146224 134146244 21 + 1.433 1.470 0.128
ENSG00000081059 E047 56.9465564 0.0050828387 9.400285e-01 9.663379e-01 5 134146245 134146369 125 + 1.747 1.744 -0.011
ENSG00000081059 E048 435.2395084 0.0003234839 3.894685e-06 2.840017e-05 5 134146370 134148236 1867 + 2.583 2.643 0.197
ENSG00000081059 E049 0.1451727 0.0425609595 3.548009e-01   5 134151656 134151865 210 + 0.143 0.000 -12.826