ENSG00000081026

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307546 ENSG00000081026 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGI3 protein_coding protein_coding 5.876323 3.455411 7.454886 0.05801234 0.2895183 1.107094 1.7937255 0.8169823 2.4883178 0.1237364 0.4499628 1.5950286 0.2971583 0.23760000 0.33960000 0.10200000 5.909482e-01 9.467868e-05 FALSE TRUE
ENST00000369615 ENSG00000081026 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGI3 protein_coding protein_coding 5.876323 3.455411 7.454886 0.05801234 0.2895183 1.107094 1.8579637 0.4884573 2.9170674 0.1109452 0.2645994 2.5539140 0.2697208 0.14153333 0.38966667 0.24813333 9.467868e-05 9.467868e-05 FALSE TRUE
ENST00000477955 ENSG00000081026 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGI3 protein_coding processed_transcript 5.876323 3.455411 7.454886 0.05801234 0.2895183 1.107094 1.6844601 1.8437549 1.4965709 0.2549416 0.2456331 -0.2991819 0.3506667 0.53226667 0.19883333 -0.33343333 7.065537e-04 9.467868e-05   FALSE
ENST00000486456 ENSG00000081026 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGI3 protein_coding processed_transcript 5.876323 3.455411 7.454886 0.05801234 0.2895183 1.107094 0.1863288 0.2739815 0.2108233 0.1447218 0.1419080 -0.3629044 0.0356875 0.07933333 0.02716667 -0.05216667 5.260926e-01 9.467868e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081026 E001 19.9185737 0.0009460259 1.882756e-02 4.895316e-02 1 113390515 113390748 234 + 1.188 1.409 0.771
ENSG00000081026 E002 14.7795641 0.0030150049 6.276424e-01 7.434150e-01 1 113390749 113390971 223 + 1.117 1.191 0.265
ENSG00000081026 E003 3.4196727 0.0214437731 6.786891e-01 7.830905e-01 1 113390972 113390988 17 + 0.604 0.548 -0.255
ENSG00000081026 E004 8.3612828 0.0030817249 3.306459e-02 7.793775e-02 1 113390989 113391130 142 + 0.965 0.680 -1.118
ENSG00000081026 E005 16.7107174 0.0011508820 6.632191e-01 7.713385e-01 1 113391131 113391260 130 + 1.174 1.241 0.236
ENSG00000081026 E006 22.4017752 0.0210024573 7.484934e-02 1.512854e-01 1 113391261 113391349 89 + 1.250 1.463 0.741
ENSG00000081026 E007 34.5916133 0.0438284171 3.685998e-09 4.917615e-08 1 113403655 113404455 801 + 1.185 1.898 2.450
ENSG00000081026 E008 21.4196192 0.0009976282 9.644154e-02 1.850165e-01 1 113549515 113549631 117 + 1.315 1.191 -0.436
ENSG00000081026 E009 24.5275936 0.0008275710 1.509475e-01 2.629558e-01 1 113580542 113580661 120 + 1.365 1.271 -0.326
ENSG00000081026 E010 4.2865763 0.3951935955 4.172125e-02 9.422719e-02 1 113580662 113581102 441 + 0.431 1.039 2.550
ENSG00000081026 E011 32.6444282 0.0007303444 2.099616e-02 5.358199e-02 1 113585387 113585596 210 + 1.497 1.351 -0.502
ENSG00000081026 E012 31.7035891 0.0211344186 7.993104e-02 1.594555e-01 1 113590484 113590658 175 + 1.485 1.336 -0.515
ENSG00000081026 E013 23.8104825 0.0102892698 2.336581e-02 5.851090e-02 1 113594481 113594560 80 + 1.374 1.172 -0.709
ENSG00000081026 E014 20.2680196 0.0009940888 2.310004e-02 5.795491e-02 1 113614601 113614658 58 + 1.304 1.114 -0.674
ENSG00000081026 E015 0.5483223 0.0202544583 1.000750e-01 1.905966e-01 1 113618532 113618606 75 + 0.067 0.355 2.911
ENSG00000081026 E016 22.4653557 0.0010900686 3.630893e-03 1.210002e-02 1 113619736 113619830 95 + 1.358 1.114 -0.864
ENSG00000081026 E017 27.4236651 0.0007182968 3.832226e-05 2.219109e-04 1 113622806 113622994 189 + 1.453 1.114 -1.190
ENSG00000081026 E018 70.2411386 0.0020375342 3.403530e-03 1.144866e-02 1 113641911 113642516 606 + 1.816 1.684 -0.445
ENSG00000081026 E019 17.3121899 0.0011404780 1.715233e-02 4.527851e-02 1 113643743 113643774 32 + 1.242 1.020 -0.797
ENSG00000081026 E020 30.2000553 0.0007425691 4.814346e-02 1.058840e-01 1 113646486 113646642 157 + 1.453 1.326 -0.437
ENSG00000081026 E021 18.3813596 0.0320881252 2.871427e-01 4.276194e-01 1 113649237 113649328 92 + 1.241 1.140 -0.359
ENSG00000081026 E022 27.5720247 0.0007700018 3.073258e-02 7.339026e-02 1 113651014 113651206 193 + 1.421 1.271 -0.519
ENSG00000081026 E023 30.5354757 0.0006755452 1.996617e-01 3.258107e-01 1 113653830 113654018 189 + 1.445 1.375 -0.240
ENSG00000081026 E024 30.2141316 0.0018171873 5.139700e-01 6.487489e-01 1 113659080 113659265 186 + 1.431 1.409 -0.078
ENSG00000081026 E025 27.2340399 0.0029353916 9.488761e-01 9.719425e-01 1 113671734 113671836 103 + 1.377 1.409 0.110
ENSG00000081026 E026 24.8619251 0.0083597533 7.048324e-01 8.032990e-01 1 113672615 113672741 127 + 1.348 1.340 -0.029
ENSG00000081026 E027 29.6568386 0.0007888840 2.723050e-01 4.111693e-01 1 113673322 113673465 144 + 1.432 1.375 -0.195
ENSG00000081026 E028 35.8958513 0.0005596954 3.982404e-01 5.419816e-01 1 113681198 113681336 139 + 1.508 1.478 -0.104
ENSG00000081026 E029 14.8581831 0.0012480697 3.934689e-01 5.373654e-01 1 113682212 113682302 91 + 1.154 1.092 -0.223
ENSG00000081026 E030 0.8814298 0.0468156815 5.454749e-01 6.758131e-01 1 113682303 113682434 132 + 0.223 0.353 0.904
ENSG00000081026 E031 35.7956064 0.0025286527 4.236354e-01 5.666909e-01 1 113682897 113683138 242 + 1.508 1.478 -0.104
ENSG00000081026 E032 103.5018609 0.0066238800 3.849589e-01 5.291080e-01 1 113683139 113684099 961 + 1.933 2.005 0.243
ENSG00000081026 E033 143.5494005 0.0007454379 6.445355e-09 8.238669e-08 1 113684100 113685923 1824 + 2.030 2.241 0.707