ENSG00000081014

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261842 ENSG00000081014 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4E1 protein_coding protein_coding 2.992861 1.218068 4.754468 0.06177261 0.1598811 1.955925 2.0561957 0.30926436 4.33133684 0.15673315 0.34216097 3.7653159 0.5190583 0.26733333 0.90836667 0.6410333 5.270748e-02 3.972286e-11 FALSE TRUE
ENST00000561397 ENSG00000081014 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4E1 protein_coding processed_transcript 2.992861 1.218068 4.754468 0.06177261 0.1598811 1.955925 0.4391771 0.78738876 0.00000000 0.17143764 0.00000000 -6.3172114 0.3147250 0.63540000 0.00000000 -0.6354000 3.972286e-11 3.972286e-11   FALSE
MSTRG.10798.1 ENSG00000081014 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4E1 protein_coding   2.992861 1.218068 4.754468 0.06177261 0.1598811 1.955925 0.3784206 0.08212644 0.09903043 0.08212644 0.09903043 0.2430436 0.1221792 0.06193333 0.02173333 -0.0402000 8.129248e-01 3.972286e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000081014 E001 1.0340911 0.0117377548 1.000000e+00 1.000000e+00 15 50908619 50908643 25 + 0.211 0.305 0.704
ENSG00000081014 E002 0.1472490 0.0430592459 8.942228e-01   15 50908672 50908672 1 + 0.043 0.000 -15.280
ENSG00000081014 E003 0.1472490 0.0430592459 8.942228e-01   15 50908673 50908682 10 + 0.043 0.000 -15.280
ENSG00000081014 E004 6.2160714 0.0032760561 5.106382e-01 6.458300e-01 15 50908683 50908794 112 + 0.647 0.910 1.053
ENSG00000081014 E005 13.1893202 0.0013121035 1.906222e-01 3.145374e-01 15 50908795 50908928 134 + 0.965 0.961 -0.013
ENSG00000081014 E006 14.8330078 0.0061238254 8.595800e-02 1.689209e-01 15 50912078 50912149 72 + 1.020 0.961 -0.218
ENSG00000081014 E007 0.4375944 0.0272526662 1.000000e+00 1.000000e+00 15 50915425 50915447 23 + 0.118 0.000 -16.864
ENSG00000081014 E008 16.6475918 0.0012478835 6.274292e-02 1.312725e-01 15 50915448 50915555 108 + 1.065 1.007 -0.213
ENSG00000081014 E009 6.8354604 0.0024004114 5.943401e-01 7.165920e-01 15 50915556 50915571 16 + 0.713 0.785 0.290
ENSG00000081014 E010 0.1817044 0.0397783228 5.717911e-02   15 50915572 50915972 401 + 0.000 0.305 21.586
ENSG00000081014 E011 0.0000000       15 50918030 50918115 86 +      
ENSG00000081014 E012 11.9694977 0.0016444885 3.279225e-01 4.714001e-01 15 50923931 50924004 74 + 0.924 0.961 0.140
ENSG00000081014 E013 16.6537358 0.0105641307 9.126481e-02 1.771029e-01 15 50925098 50925219 122 + 1.061 1.008 -0.197
ENSG00000081014 E014 18.7805718 0.0092328144 2.121709e-01 3.410905e-01 15 50929009 50929168 160 + 1.099 1.122 0.084
ENSG00000081014 E015 19.1852251 0.0105973670 4.967369e-03 1.583865e-02 15 50930805 50930971 167 + 1.130 0.911 -0.808
ENSG00000081014 E016 0.1451727 0.0426714509 8.924577e-01   15 50934536 50934623 88 + 0.043 0.000 -15.279
ENSG00000081014 E017 11.3967630 0.0109692809 6.335066e-02 1.322796e-01 15 50934624 50934697 74 + 0.919 0.785 -0.516
ENSG00000081014 E018 14.2077486 0.0076523258 1.022348e-02 2.931670e-02 15 50941442 50941564 123 + 1.011 0.785 -0.863
ENSG00000081014 E019 10.8031087 0.0219042551 1.050689e-01 1.981857e-01 15 50941666 50941697 32 + 0.896 0.786 -0.426
ENSG00000081014 E020 15.0431810 0.0054440394 8.720451e-02 1.709025e-01 15 50941698 50941775 78 + 1.020 0.961 -0.217
ENSG00000081014 E021 19.4477689 0.0010929531 1.977713e-03 7.157739e-03 15 50948020 50948159 140 + 1.137 0.910 -0.833
ENSG00000081014 E022 0.5911862 0.0186200011 7.252612e-01 8.185892e-01 15 50949824 50949825 2 + 0.151 0.000 -17.280
ENSG00000081014 E023 15.3234214 0.0180200703 1.968198e-02 5.081346e-02 15 50949826 50949938 113 + 1.041 0.852 -0.709
ENSG00000081014 E024 16.8325210 0.0012923514 3.304076e-03 1.116049e-02 15 50950051 50950169 119 + 1.084 0.852 -0.867
ENSG00000081014 E025 34.2034266 0.0009215442 1.138847e-03 4.433436e-03 15 50958492 50958794 303 + 1.363 1.238 -0.438
ENSG00000081014 E026 17.2133465 0.0010335108 4.942551e-02 1.081387e-01 15 50968263 50968377 115 + 1.077 1.007 -0.254
ENSG00000081014 E027 17.2605359 0.0051413940 2.411625e-02 6.005035e-02 15 50984022 50984145 124 + 1.084 0.961 -0.450
ENSG00000081014 E028 30.4085314 0.0007178426 8.729940e-03 2.561028e-02 15 50993370 50993625 256 + 1.309 1.238 -0.249
ENSG00000081014 E029 40.0056079 0.0127361938 2.672309e-01 4.055306e-01 15 50997326 50997748 423 + 1.406 1.485 0.272
ENSG00000081014 E030 18.4197028 0.0010943560 4.481123e-01 5.894253e-01 15 50997749 50997883 135 + 1.088 1.183 0.342
ENSG00000081014 E031 19.2343694 0.0010239723 5.562953e-01 6.849678e-01 15 50999072 50999262 191 + 1.095 1.211 0.416
ENSG00000081014 E032 17.8136781 0.0274375525 7.816931e-02 1.565262e-01 15 51001026 51001183 158 + 1.088 1.011 -0.280
ENSG00000081014 E033 247.5041727 0.0325619827 1.966793e-07 1.886884e-06 15 51002502 51005895 3394 + 2.108 2.579 1.573