ENSG00000080854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000530957 ENSG00000080854 HEK293_OSMI2_2hA HEK293_TMG_2hB IGSF9B protein_coding processed_transcript 3.539604 2.349933 3.636547 0.2547797 0.2711653 0.627785 0.2673717 0.1863901 0.4091096 0.09443839 0.09857722 1.09360554 0.07347917 0.08643333 0.1159667 0.029533333 0.823802218 0.004236456   FALSE
ENST00000533871 ENSG00000080854 HEK293_OSMI2_2hA HEK293_TMG_2hB IGSF9B protein_coding protein_coding 3.539604 2.349933 3.636547 0.2547797 0.2711653 0.627785 1.4210387 1.2996433 1.2228669 0.06359907 0.11822820 -0.08715682 0.42953333 0.56113333 0.3357667 -0.225366667 0.004236456 0.004236456 FALSE TRUE
ENST00000564347 ENSG00000080854 HEK293_OSMI2_2hA HEK293_TMG_2hB IGSF9B protein_coding processed_transcript 3.539604 2.349933 3.636547 0.2547797 0.2711653 0.627785 0.8279558 0.5186890 0.8100988 0.12830420 0.14842073 0.63337837 0.22199583 0.21356667 0.2202000 0.006633333 0.990179429 0.004236456 FALSE FALSE
ENST00000582977 ENSG00000080854 HEK293_OSMI2_2hA HEK293_TMG_2hB IGSF9B protein_coding miRNA 3.539604 2.349933 3.636547 0.2547797 0.2711653 0.627785 0.8675888 0.3452109 0.9089060 0.14029129 0.01131902 1.37124151 0.23054583 0.13880000 0.2526333 0.113833333 0.206137990 0.004236456 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080854 E001 127.8548982 0.0076556976 3.929875e-12 8.740450e-11 11 133896438 133898503 2066 - 1.888 2.251 1.217
ENSG00000080854 E002 519.3627863 0.0031872474 9.859916e-01 9.952534e-01 11 133898504 133908563 10060 - 2.697 2.729 0.107
ENSG00000080854 E003 32.2289582 0.0006292963 7.628164e-01 8.463318e-01 11 133908564 133909182 619 - 1.496 1.538 0.147
ENSG00000080854 E004 15.4262668 0.0013050153 4.814390e-01 6.196645e-01 11 133909183 133909277 95 - 1.170 1.254 0.296
ENSG00000080854 E005 14.6438415 0.0105580545 8.800369e-01 9.270637e-01 11 133911886 133912007 122 - 1.179 1.217 0.137
ENSG00000080854 E006 1.1008118 0.0123278156 8.107465e-01 8.799450e-01 11 133912008 133912118 111 - 0.342 0.314 -0.181
ENSG00000080854 E007 4.1112652 0.0044029524 7.381332e-01 8.281001e-01 11 133912295 133912362 68 - 0.716 0.689 -0.113
ENSG00000080854 E008 0.9953799 0.0122191484 8.997491e-01 9.400355e-01 11 133919039 133919105 67 - 0.279 0.314 0.235
ENSG00000080854 E009 46.6891633 0.0050209612 3.336121e-01 4.773514e-01 11 133919742 133921397 1656 - 1.690 1.660 -0.103
ENSG00000080854 E010 5.3351166 0.0278216144 5.715910e-02 1.217383e-01 11 133922177 133922222 46 - 0.914 0.657 -1.026
ENSG00000080854 E011 3.6420745 0.0410570167 6.210230e-02 1.301751e-01 11 133922569 133922575 7 - 0.785 0.495 -1.260
ENSG00000080854 E012 8.7746432 0.0768249603 2.159206e-01 3.455119e-01 11 133922576 133922730 155 - 1.061 0.895 -0.619
ENSG00000080854 E013 7.7541433 0.0084351025 1.989712e-01 3.249246e-01 11 133924820 133924904 85 - 1.000 0.867 -0.500
ENSG00000080854 E014 10.9390465 0.0016101034 3.366490e-03 1.134098e-02 11 133925739 133925965 227 - 1.196 0.925 -0.988
ENSG00000080854 E015 9.2439386 0.0019082478 4.926996e-02 1.078681e-01 11 133926916 133927091 176 - 1.093 0.906 -0.691
ENSG00000080854 E016 6.6927332 0.0031849000 2.322793e-01 3.651471e-01 11 133929671 133929782 112 - 0.944 0.823 -0.465
ENSG00000080854 E017 9.2022086 0.0018350288 3.344046e-02 7.866289e-02 11 133930984 133931134 151 - 1.093 0.887 -0.764
ENSG00000080854 E018 7.9048816 0.0206768134 1.519058e-01 2.642544e-01 11 133931453 133931569 117 - 1.026 0.866 -0.599
ENSG00000080854 E019 8.2233397 0.0489366185 2.316706e-01 3.644443e-01 11 133931655 133931795 141 - 1.038 0.886 -0.567
ENSG00000080854 E020 9.6509002 0.0032642082 2.597076e-01 3.971620e-01 11 133932071 133932213 143 - 1.072 0.977 -0.350
ENSG00000080854 E021 1.0653123 0.0122190477 6.645501e-02 1.374812e-01 11 133934471 133934520 50 - 0.447 0.131 -2.350
ENSG00000080854 E022 8.3590605 0.0032801857 5.325811e-02 1.149444e-01 11 133935617 133935762 146 - 1.061 0.866 -0.725
ENSG00000080854 E023 8.5398068 0.0023637997 9.484099e-02 1.826469e-01 11 133936053 133936194 142 - 1.049 0.887 -0.604
ENSG00000080854 E024 6.8337791 0.1187640497 2.706939e-01 4.093305e-01 11 133937376 133937406 31 - 0.986 0.791 -0.745
ENSG00000080854 E025 9.3247896 0.0302859310 1.360362e-01 2.425246e-01 11 133937407 133937493 87 - 1.093 0.909 -0.682
ENSG00000080854 E026 8.4934473 0.0295534477 2.106509e-02 5.373145e-02 11 133937810 133937961 152 - 1.093 0.803 -1.089
ENSG00000080854 E027 0.1817044 0.0392356683 4.433490e-01   11 133937962 133938100 139 - 0.000 0.131 9.080
ENSG00000080854 E028 4.9246386 0.0994572281 1.649794e-01 2.816691e-01 11 133944220 133944283 64 - 0.862 0.631 -0.938
ENSG00000080854 E029 5.7434379 0.0043748279 4.463132e-02 9.952411e-02 11 133944284 133944366 83 - 0.929 0.689 -0.948
ENSG00000080854 E030 7.2341517 0.0023934362 3.438131e-03 1.154762e-02 11 133946061 133946258 198 - 1.049 0.719 -1.267
ENSG00000080854 E031 0.0000000       11 133946259 133946292 34 -      
ENSG00000080854 E032 0.0000000       11 133951933 133952216 284 -      
ENSG00000080854 E033 5.0899007 0.0033150776 5.201518e-04 2.235305e-03 11 133956691 133956984 294 - 0.959 0.494 -1.935