ENSG00000080845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340491 ENSG00000080845 HEK293_OSMI2_2hA HEK293_TMG_2hB DLGAP4 protein_coding protein_coding 11.78799 14.38776 9.718112 0.8758663 0.3526166 -0.5656126 4.1585438 4.995890 3.8486495 0.5767866 0.1424984 -0.3755306 0.35627500 0.3450000 0.3976333 0.05263333 5.234032e-01 1.235174e-05 FALSE TRUE
ENST00000475894 ENSG00000080845 HEK293_OSMI2_2hA HEK293_TMG_2hB DLGAP4 protein_coding protein_coding 11.78799 14.38776 9.718112 0.8758663 0.3526166 -0.5656126 3.5284607 7.212869 2.2841087 0.3560928 0.2009866 -1.6546382 0.28254167 0.5046667 0.2348000 -0.26986667 1.235174e-05 1.235174e-05 FALSE TRUE
ENST00000479220 ENSG00000080845 HEK293_OSMI2_2hA HEK293_TMG_2hB DLGAP4 protein_coding processed_transcript 11.78799 14.38776 9.718112 0.8758663 0.3526166 -0.5656126 0.6406728 0.000000 0.0000000 0.0000000 0.0000000 0.0000000 0.05953333 0.0000000 0.0000000 0.00000000   1.235174e-05 FALSE FALSE
ENST00000491207 ENSG00000080845 HEK293_OSMI2_2hA HEK293_TMG_2hB DLGAP4 protein_coding processed_transcript 11.78799 14.38776 9.718112 0.8758663 0.3526166 -0.5656126 0.4796137 0.000000 1.0737763 0.0000000 0.5558769 6.7599231 0.04083333 0.0000000 0.1084000 0.10840000 1.471435e-01 1.235174e-05 FALSE FALSE
ENST00000495241 ENSG00000080845 HEK293_OSMI2_2hA HEK293_TMG_2hB DLGAP4 protein_coding protein_coding 11.78799 14.38776 9.718112 0.8758663 0.3526166 -0.5656126 1.0609747 0.000000 0.4705153 0.0000000 0.4705153 5.5865104 0.09385833 0.0000000 0.0498000 0.04980000 7.883591e-01 1.235174e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080845 E001 0.7406253 0.0155242727 0.0021495551 0.007689037 20 36306336 36306338 3 + 0.512 0.000 -13.176
ENSG00000080845 E002 2.0241605 0.0072010269 0.0018834058 0.006863090 20 36306339 36306512 174 + 0.740 0.232 -2.672
ENSG00000080845 E003 3.3420598 0.0048802239 0.5928714890 0.715339715 20 36367045 36367148 104 + 0.663 0.583 -0.350
ENSG00000080845 E004 5.5834217 0.0030155120 0.7951929171 0.869188679 20 36367149 36367275 127 + 0.806 0.774 -0.127
ENSG00000080845 E005 30.4033920 0.0169155022 0.1152999741 0.213287839 20 36431646 36432643 998 + 1.546 1.411 -0.464
ENSG00000080845 E006 5.2263662 0.0032392857 0.3821898412 0.526422804 20 36432644 36432716 73 + 0.663 0.791 0.525
ENSG00000080845 E007 11.4127290 0.0016632733 0.5959220949 0.717946389 20 36436109 36436350 242 + 1.088 1.037 -0.186
ENSG00000080845 E008 12.4438729 0.0211742951 0.2882257499 0.428784040 20 36439754 36439868 115 + 1.161 1.043 -0.428
ENSG00000080845 E009 7.7533294 0.0167529686 0.9901564390 0.997942038 20 36442727 36442777 51 + 0.890 0.897 0.027
ENSG00000080845 E010 19.2766660 0.0009888596 0.0821742916 0.162948501 20 36446697 36446937 241 + 1.354 1.219 -0.475
ENSG00000080845 E011 5.3424682 0.0043261886 0.6320953612 0.747009244 20 36461338 36461467 130 + 0.703 0.775 0.290
ENSG00000080845 E012 5.8270911 0.0028719718 0.6234433099 0.740020330 20 36461468 36461477 10 + 0.836 0.774 -0.243
ENSG00000080845 E013 5.8270911 0.0028719718 0.6234433099 0.740020330 20 36461478 36461479 2 + 0.836 0.774 -0.243
ENSG00000080845 E014 21.0929579 0.0008960702 0.0110751330 0.031347029 20 36461480 36461491 12 + 1.426 1.237 -0.659
ENSG00000080845 E015 23.7972850 0.0008014100 0.0078477739 0.023400655 20 36461492 36461510 19 + 1.474 1.287 -0.649
ENSG00000080845 E016 61.0714017 0.0022888295 0.0001399904 0.000703548 20 36461747 36462265 519 + 1.871 1.685 -0.628
ENSG00000080845 E017 71.0853439 0.0004323140 0.0001544547 0.000766817 20 36462266 36462599 334 + 1.919 1.760 -0.535
ENSG00000080845 E018 2.4379166 0.0065345953 0.5060569284 0.641745265 20 36465265 36465367 103 + 0.568 0.460 -0.519
ENSG00000080845 E019 0.0000000       20 36473119 36473172 54 +      
ENSG00000080845 E020 0.3299976 0.0279579562 0.4434163701   20 36492383 36493057 675 + 0.000 0.167 11.852
ENSG00000080845 E021 0.1817044 0.0399655736 0.9348065156   20 36493058 36493185 128 + 0.000 0.092 10.768
ENSG00000080845 E022 154.4502423 0.0002352324 0.0181181030 0.047383596 20 36496705 36496994 290 + 2.195 2.130 -0.219
ENSG00000080845 E023 86.6775020 0.0027650874 0.9014666770 0.941207164 20 36496995 36497066 72 + 1.899 1.909 0.032
ENSG00000080845 E024 2.3238779 0.0065354263 0.9030653150 0.942340701 20 36497447 36497602 156 + 0.512 0.494 -0.088
ENSG00000080845 E025 12.1481244 0.0014321447 0.0002316316 0.001098421 20 36497817 36499241 1425 + 1.289 0.943 -1.248
ENSG00000080845 E026 1.4811593 0.0160677622 0.5321101313 0.664482641 20 36499242 36499321 80 + 0.447 0.338 -0.614
ENSG00000080845 E027 60.6397126 0.0098578448 0.6179323939 0.735677628 20 36499588 36499602 15 + 1.774 1.746 -0.097
ENSG00000080845 E028 103.7223185 0.0003369907 0.4336419504 0.576051704 20 36499603 36499676 74 + 1.998 1.973 -0.084
ENSG00000080845 E029 0.3289534 0.0285980980 0.6333977761   20 36500197 36500198 2 + 0.161 0.092 -0.935
ENSG00000080845 E030 109.4020710 0.0002636430 0.7388323463 0.828614560 20 36500199 36500275 77 + 1.990 2.006 0.052
ENSG00000080845 E031 169.9743315 0.0002055355 0.0844470341 0.166521679 20 36500276 36500506 231 + 2.153 2.207 0.178
ENSG00000080845 E032 115.2867740 0.0002599927 0.0459469948 0.101938055 20 36500507 36500611 105 + 1.972 2.046 0.249
ENSG00000080845 E033 107.3961275 0.0003189396 0.1241981786 0.225972862 20 36524250 36524325 76 + 1.950 2.011 0.202
ENSG00000080845 E034 79.9868987 0.0003799680 0.2458901845 0.381126265 20 36524326 36524341 16 + 1.827 1.880 0.179
ENSG00000080845 E035 170.7398917 0.0005143920 0.1364642343 0.243132263 20 36525851 36526006 156 + 2.156 2.205 0.163
ENSG00000080845 E036 1.6971922 0.0080609334 0.7823576273 0.860256457 20 36526007 36526077 71 + 0.371 0.423 0.287
ENSG00000080845 E037 499.6420425 0.0012389142 0.0004623910 0.002015800 20 36526813 36528637 1825 + 2.606 2.682 0.254