ENSG00000080839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373664 ENSG00000080839 HEK293_OSMI2_2hA HEK293_TMG_2hB RBL1 protein_coding protein_coding 6.632882 1.58862 11.97221 0.05239492 1.272797 2.905995 4.6559338 1.533467 8.691695 0.08055492 0.2559807 2.495122 0.80654167 0.9641333 0.7370667 -0.2270667 0.001596029 0.001596029 FALSE TRUE
ENST00000525052 ENSG00000080839 HEK293_OSMI2_2hA HEK293_TMG_2hB RBL1 protein_coding protein_coding 6.632882 1.58862 11.97221 0.05239492 1.272797 2.905995 0.2662480 0.000000 1.200117 0.00000000 0.8582726 6.919003 0.01965417 0.0000000 0.0882000 0.0882000 0.506356795 0.001596029 FALSE FALSE
MSTRG.20669.3 ENSG00000080839 HEK293_OSMI2_2hA HEK293_TMG_2hB RBL1 protein_coding   6.632882 1.58862 11.97221 0.05239492 1.272797 2.905995 0.8882266 0.000000 1.230259 0.00000000 0.3028812 6.954497 0.08108750 0.0000000 0.1092667 0.1092667 0.003794612 0.001596029 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080839 E001 285.498875 0.0106432663 1.374498e-10 2.370672e-09 20 36996349 36998560 2212 - 2.232 2.586 1.183
ENSG00000080839 E002 23.075249 0.0008083040 1.759324e-01 2.959131e-01 20 36998561 36998676 116 - 1.203 1.393 0.665
ENSG00000080839 E003 56.874048 0.0004167989 6.452843e-01 7.574124e-01 20 36998677 36998929 253 - 1.595 1.693 0.333
ENSG00000080839 E004 0.147249 0.0429695684 9.132906e-01   20 37003574 37003701 128 - 0.049 0.001 -5.917
ENSG00000080839 E005 41.353190 0.0005403506 9.818260e-01 9.926576e-01 20 37003702 37003866 165 - 1.466 1.536 0.242
ENSG00000080839 E006 37.441115 0.0005791466 9.872658e-01 9.960946e-01 20 37007411 37007559 149 - 1.422 1.489 0.231
ENSG00000080839 E007 32.047481 0.0007433459 1.111478e-01 2.072318e-01 20 37018279 37018369 91 - 1.332 1.525 0.665
ENSG00000080839 E008 29.064474 0.0007291649 3.330608e-01 4.767313e-01 20 37020659 37020730 72 - 1.302 1.451 0.515
ENSG00000080839 E009 52.413906 0.0004316211 7.683565e-01 8.503198e-01 20 37022650 37022826 177 - 1.567 1.617 0.169
ENSG00000080839 E010 71.698867 0.0004092418 4.765273e-02 1.050022e-01 20 37032665 37032876 212 - 1.717 1.669 -0.164
ENSG00000080839 E011 81.450611 0.0003527296 1.579608e-01 2.724188e-01 20 37035242 37035508 267 - 1.765 1.757 -0.025
ENSG00000080839 E012 41.603306 0.0005112572 3.461532e-01 4.903188e-01 20 37040153 37040285 133 - 1.480 1.477 -0.010
ENSG00000080839 E013 45.398822 0.0004703026 3.242163e-01 4.675910e-01 20 37044086 37044250 165 - 1.516 1.513 -0.010
ENSG00000080839 E014 39.187218 0.0005829839 1.343589e-01 2.402180e-01 20 37047053 37047190 138 - 1.460 1.408 -0.180
ENSG00000080839 E015 37.491998 0.0005853068 1.039525e-01 1.965258e-01 20 37055553 37055656 104 - 1.444 1.377 -0.230
ENSG00000080839 E016 20.744679 0.0009104962 2.996971e-01 4.412653e-01 20 37056146 37056159 14 - 1.196 1.151 -0.160
ENSG00000080839 E017 36.028799 0.0010609933 7.563580e-02 1.525235e-01 20 37056160 37056258 99 - 1.428 1.344 -0.292
ENSG00000080839 E018 54.644852 0.0004094432 4.859348e-03 1.554025e-02 20 37061103 37061269 167 - 1.609 1.477 -0.453
ENSG00000080839 E019 1.713856 0.0244411696 6.828360e-01 7.861993e-01 20 37061946 37062083 138 - 0.319 0.441 0.699
ENSG00000080839 E020 61.955551 0.0004491229 1.885382e-05 1.176482e-04 20 37062084 37062270 187 - 1.674 1.437 -0.810
ENSG00000080839 E021 30.582871 0.0007769731 1.332199e-01 2.386108e-01 20 37065424 37065473 50 - 1.358 1.289 -0.243
ENSG00000080839 E022 55.819855 0.0030809811 5.661662e-04 2.407112e-03 20 37066724 37066884 161 - 1.626 1.423 -0.694
ENSG00000080839 E023 29.019756 0.0006770072 5.515939e-06 3.888580e-05 20 37066993 37067021 29 - 1.370 0.904 -1.675
ENSG00000080839 E024 35.650820 0.0006850630 2.350857e-05 1.434295e-04 20 37067022 37067121 100 - 1.449 1.094 -1.249
ENSG00000080839 E025 21.776896 0.0017270652 1.674525e-02 4.437705e-02 20 37067233 37067297 65 - 1.238 1.028 -0.754
ENSG00000080839 E026 27.976080 0.0017261678 2.827533e-02 6.855318e-02 20 37067986 37068086 101 - 1.332 1.178 -0.545
ENSG00000080839 E027 22.101317 0.0086405285 8.512108e-02 1.676031e-01 20 37068087 37068186 100 - 1.234 1.094 -0.499
ENSG00000080839 E028 0.000000       20 37081888 37082029 142 -      
ENSG00000080839 E029 28.895146 0.0007146512 7.371654e-01 8.274063e-01 20 37088989 37089122 134 - 1.323 1.361 0.133
ENSG00000080839 E030 25.002589 0.0007872063 9.693850e-01 9.848666e-01 20 37095773 37095997 225 - 1.255 1.326 0.248