ENSG00000080824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216281 ENSG00000080824 HEK293_OSMI2_2hA HEK293_TMG_2hB HSP90AA1 protein_coding protein_coding 597.3928 199.734 947.9651 3.524638 23.10722 2.246697 563.0448 195.1342 871.07344 3.29467 30.903795 2.158271 0.9544458 0.9770333 0.91840000 -0.05863333 1.070466e-03 4.276803e-28 FALSE  
ENST00000553585 ENSG00000080824 HEK293_OSMI2_2hA HEK293_TMG_2hB HSP90AA1 protein_coding protein_coding 597.3928 199.734 947.9651 3.524638 23.10722 2.246697 20.9104 0.0000 51.32707 0.00000 8.772615 12.325785 0.0217875 0.0000000 0.05466667 0.05466667 4.276803e-28 4.276803e-28 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080824 E001 182.392617 0.0104893040 2.142144e-12 4.978808e-11 14 102080742 102081048 307 - 2.037 2.487 1.504
ENSG00000080824 E002 634.098719 0.0179007875 6.805510e-08 7.141262e-07 14 102081049 102081092 44 - 2.588 3.007 1.392
ENSG00000080824 E003 3948.343630 0.0108694720 7.026622e-09 8.913703e-08 14 102081093 102081265 173 - 3.415 3.747 1.106
ENSG00000080824 E004 11179.919199 0.0053821970 2.975620e-12 6.758157e-11 14 102081266 102081821 556 - 3.893 4.150 0.856
ENSG00000080824 E005 7947.215122 0.0010634519 3.151842e-10 5.114407e-09 14 102082111 102082444 334 - 3.782 3.915 0.441
ENSG00000080824 E006 80.291606 0.0007710995 3.379304e-03 1.137687e-02 14 102082665 102083033 369 - 1.846 1.726 -0.405
ENSG00000080824 E007 7320.887264 0.0007301298 8.079814e-02 1.607891e-01 14 102083034 102083302 269 - 3.765 3.823 0.193
ENSG00000080824 E008 16.395186 0.0637829676 3.818689e-01 5.261352e-01 14 102083442 102083545 104 - 1.178 1.060 -0.425
ENSG00000080824 E009 4570.979865 0.0008735481 7.581754e-01 8.428229e-01 14 102083546 102083693 148 - 3.565 3.604 0.130
ENSG00000080824 E010 3972.074541 0.0025028616 2.168159e-01 3.465729e-01 14 102083793 102083895 103 - 3.511 3.516 0.015
ENSG00000080824 E011 3520.165262 0.0055097774 2.390170e-01 3.729782e-01 14 102083896 102083983 88 - 3.461 3.455 -0.020
ENSG00000080824 E012 6.568709 0.1000021782 1.830295e-01 3.049880e-01 14 102083984 102084234 251 - 0.845 0.579 -1.106
ENSG00000080824 E013 4383.641921 0.0043146399 3.268618e-01 4.703000e-01 14 102084399 102084564 166 - 3.554 3.559 0.015
ENSG00000080824 E014 6.082871 0.0556446049 7.766753e-02 1.557129e-01 14 102084565 102084680 116 - 0.827 0.488 -1.462
ENSG00000080824 E015 5240.139572 0.0032321535 2.676197e-03 9.301784e-03 14 102084681 102084932 252 - 3.643 3.592 -0.172
ENSG00000080824 E016 2237.322497 0.0094653667 5.323457e-04 2.280826e-03 14 102084933 102084979 47 - 3.290 3.147 -0.477
ENSG00000080824 E017 2122.847855 0.0051352535 2.400634e-06 1.835397e-05 14 102084980 102084998 19 - 3.268 3.124 -0.478
ENSG00000080824 E018 4278.696646 0.0012551810 1.470597e-19 8.943828e-18 14 102085298 102085431 134 - 3.570 3.436 -0.445
ENSG00000080824 E019 19.581419 0.0030926586 7.783074e-02 1.559950e-01 14 102085432 102085707 276 - 1.254 1.104 -0.535
ENSG00000080824 E020 4515.644784 0.0020265675 8.209389e-12 1.732670e-10 14 102085758 102085885 128 - 3.591 3.471 -0.397
ENSG00000080824 E021 2387.387489 0.0021771558 2.694828e-08 3.062183e-07 14 102085886 102085918 33 - 3.311 3.208 -0.343
ENSG00000080824 E022 2388.318948 0.0030598199 2.335893e-07 2.211092e-06 14 102085919 102085964 46 - 3.314 3.199 -0.379
ENSG00000080824 E023 4668.878464 0.0057580427 1.697120e-07 1.649468e-06 14 102085965 102086124 160 - 3.612 3.454 -0.524
ENSG00000080824 E024 3.784217 0.0392798048 1.488325e-01 2.600879e-01 14 102086125 102086216 92 - 0.657 0.376 -1.359
ENSG00000080824 E025 4330.652025 0.0083852547 6.199131e-09 7.952913e-08 14 102086217 102086378 162 - 3.589 3.366 -0.743
ENSG00000080824 E026 2111.142162 0.0101049169 1.601628e-08 1.900674e-07 14 102086986 102087044 59 - 3.281 3.030 -0.832
ENSG00000080824 E027 35.718463 0.0077444257 4.897402e-01 6.271321e-01 14 102101875 102101937 63 - 1.481 1.457 -0.082
ENSG00000080824 E028 43.716075 0.0098037790 6.530365e-01 7.636260e-01 14 102101938 102102082 145 - 1.566 1.565 -0.002
ENSG00000080824 E029 13.339595 0.0012672690 5.640163e-01 6.914145e-01 14 102102083 102102085 3 - 1.054 1.148 0.339
ENSG00000080824 E030 0.000000       14 102117586 102117700 115 -      
ENSG00000080824 E031 58.125450 0.0052379989 1.980770e-03 7.167434e-03 14 102139250 102139722 473 - 1.623 1.850 0.767