ENSG00000080823

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518686 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding retained_intron 11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 2.1636718 2.6487259 1.3409095 0.3256438 0.16941906 -0.9768040 0.19628750 0.20033333 0.14873333 -0.051600000 0.5400917006 0.0009370995 TRUE  
ENST00000519058 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding protein_coding 11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 0.9023641 0.9776740 0.4896447 0.7621575 0.28137774 -0.9831324 0.08261667 0.07876667 0.05560000 -0.023166667 1.0000000000 0.0009370995 FALSE  
ENST00000520266 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding processed_transcript 11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 0.2077254 0.9948242 0.2082274 0.1388557 0.02131109 -2.2030390 0.01717917 0.07440000 0.02286667 -0.051533333 0.0009370995 0.0009370995    
ENST00000521937 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding protein_coding 11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 1.9507221 1.9902787 1.2493487 1.0471604 0.38506179 -0.6675232 0.16677917 0.14263333 0.13496667 -0.007666667 0.9298664955 0.0009370995 FALSE  
ENST00000522874 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding protein_coding 11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 0.8733761 1.2542517 0.8619308 0.3614278 0.38678479 -0.5359983 0.07860417 0.09470000 0.09430000 -0.000400000 0.9507666499 0.0009370995 FALSE  
MSTRG.10203.23 ENSG00000080823 HEK293_OSMI2_2hA HEK293_TMG_2hB MOK protein_coding   11.05017 13.29066 9.11318 0.6529967 0.2982203 -0.5438892 0.8273739 0.7118454 1.0791863 0.3590267 0.01100764 0.5934890 0.07760000 0.05620000 0.11876667 0.062566667 0.5686985444 0.0009370995 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080823 E001 2.1485031 0.0184238193 7.744445e-01 0.8546158946 14 102224500 102224655 156 - 0.509 0.462 -0.234
ENSG00000080823 E002 4.3844657 0.0037651926 6.761010e-01 0.7811820047 14 102224656 102224794 139 - 0.660 0.722 0.260
ENSG00000080823 E003 2.4293969 0.0219991981 5.577416e-01 0.6861065549 14 102225095 102225219 125 - 0.565 0.464 -0.489
ENSG00000080823 E004 9.5116992 0.0217240430 4.437976e-02 0.0990692757 14 102225220 102225945 726 - 1.144 0.897 -0.908
ENSG00000080823 E005 3.2420283 0.0349393170 1.558836e-01 0.2696217808 14 102225946 102226139 194 - 0.737 0.499 -1.049
ENSG00000080823 E006 2.7408588 0.1022138650 9.305636e-01 0.9603228642 14 102226140 102226408 269 - 0.566 0.530 -0.168
ENSG00000080823 E007 0.1482932 0.0412516160 8.769725e-01   14 102228827 102228830 4 - 0.000 0.092 9.895
ENSG00000080823 E008 0.1482932 0.0412516160 8.769725e-01   14 102228831 102228835 5 - 0.000 0.092 9.895
ENSG00000080823 E009 0.1482932 0.0412516160 8.769725e-01   14 102228836 102228838 3 - 0.000 0.092 9.895
ENSG00000080823 E010 12.5571541 0.0014814481 2.510033e-01 0.3871383660 14 102228839 102228885 47 - 1.016 1.133 0.425
ENSG00000080823 E011 33.0652082 0.0075095106 1.787961e-01 0.2996415296 14 102228886 102228989 104 - 1.422 1.524 0.350
ENSG00000080823 E012 27.4607954 0.0192745769 1.860975e-01 0.3088562891 14 102228990 102228992 3 - 1.324 1.452 0.445
ENSG00000080823 E013 38.1638139 0.0115693710 2.332026e-02 0.0584153531 14 102228993 102229072 80 - 1.422 1.604 0.624
ENSG00000080823 E014 27.4307689 0.0007527610 2.261779e-02 0.0569584755 14 102229073 102229119 47 - 1.295 1.463 0.581
ENSG00000080823 E015 19.2092935 0.0053812179 3.837451e-02 0.0880553284 14 102229120 102229123 4 - 1.130 1.321 0.675
ENSG00000080823 E016 21.8204954 0.0013021298 5.861989e-02 0.1242655410 14 102229124 102229136 13 - 1.209 1.363 0.542
ENSG00000080823 E017 23.4373340 0.0010486521 1.823149e-02 0.0476373951 14 102229137 102229159 23 - 1.209 1.398 0.662
ENSG00000080823 E018 26.9142096 0.0145442300 6.963457e-02 0.1427495930 14 102229160 102229185 26 - 1.286 1.451 0.576
ENSG00000080823 E019 37.4398466 0.0005742303 2.792515e-02 0.0678657852 14 102229186 102229208 23 - 1.450 1.588 0.472
ENSG00000080823 E020 32.9770055 0.0006586923 4.740793e-02 0.1045600505 14 102229209 102229213 5 - 1.399 1.532 0.454
ENSG00000080823 E021 54.5034579 0.0005285755 1.728420e-02 0.0455745315 14 102229214 102229266 53 - 1.619 1.743 0.421
ENSG00000080823 E022 69.7940761 0.0003757282 1.278739e-01 0.2312132221 14 102229267 102229362 96 - 1.767 1.837 0.233
ENSG00000080823 E023 36.1951720 0.0005534761 4.194744e-01 0.5627260732 14 102229363 102229366 4 - 1.570 1.522 -0.163
ENSG00000080823 E024 27.3989954 0.0031579180 3.031271e-01 0.4450253696 14 102229367 102229432 66 - 1.359 1.437 0.271
ENSG00000080823 E025 18.4676472 0.0045110005 2.875433e-02 0.0695116707 14 102229433 102229438 6 - 1.100 1.306 0.730
ENSG00000080823 E026 18.9794509 0.0012300868 3.933967e-02 0.0898012065 14 102229439 102229456 18 - 1.130 1.311 0.641
ENSG00000080823 E027 80.1666970 0.0059737318 8.165147e-01 0.8839012430 14 102229457 102229577 121 - 1.867 1.884 0.055
ENSG00000080823 E028 50.2228368 0.0019588107 6.163622e-01 0.7344313396 14 102229578 102229619 42 - 1.659 1.689 0.101
ENSG00000080823 E029 42.7386247 0.0063530694 9.179384e-01 0.9521413136 14 102229620 102229651 32 - 1.605 1.614 0.030
ENSG00000080823 E030 32.5252269 0.0021916387 9.364170e-01 0.9640226904 14 102229652 102229657 6 - 1.490 1.496 0.022
ENSG00000080823 E031 17.6316317 0.0363198936 8.792416e-01 0.9264267748 14 102229658 102231706 2049 - 1.244 1.233 -0.038
ENSG00000080823 E032 26.2872652 0.0007851479 6.387568e-01 0.7523332844 14 102231707 102231745 39 - 1.376 1.410 0.118
ENSG00000080823 E033 33.2515254 0.0006582494 8.019243e-01 0.8737840495 14 102231746 102231821 76 - 1.490 1.506 0.057
ENSG00000080823 E034 4.4283475 0.6410386629 9.675498e-01 0.9837036288 14 102231822 102232534 713 - 0.659 0.721 0.259
ENSG00000080823 E035 43.2595049 0.0026629325 4.804622e-01 0.6187519445 14 102232535 102232552 18 - 1.642 1.601 -0.140
ENSG00000080823 E036 67.0240145 0.0013330296 5.436437e-01 0.6742278540 14 102232553 102232671 119 - 1.820 1.793 -0.091
ENSG00000080823 E037 31.0144000 0.0078561941 3.183115e-01 0.4612802040 14 102232672 102232708 37 - 1.526 1.453 -0.251
ENSG00000080823 E038 62.6889349 0.0052983223 5.466594e-01 0.6767893923 14 102232709 102233338 630 - 1.740 1.776 0.120
ENSG00000080823 E039 31.3608666 0.0006688585 7.002077e-03 0.0212287749 14 102233339 102233463 125 - 1.342 1.528 0.643
ENSG00000080823 E040 31.7015357 0.0007273630 1.368218e-02 0.0374983299 14 102233464 102233687 224 - 1.359 1.528 0.583
ENSG00000080823 E041 43.5172597 0.0068939024 3.549745e-02 0.0826112411 14 102233688 102233760 73 - 1.707 1.572 -0.458
ENSG00000080823 E042 33.6728163 0.0006473661 8.436386e-02 0.1663975122 14 102233761 102233789 29 - 1.575 1.470 -0.361
ENSG00000080823 E043 0.2955422 0.0292157873 6.432353e-01   14 102233790 102233809 20 - 0.160 0.092 -0.912
ENSG00000080823 E044 0.6685028 0.0164301254 5.343179e-01 0.6663813694 14 102233810 102234153 344 - 0.277 0.169 -0.910
ENSG00000080823 E045 0.5212538 0.0201925366 1.000000e+00 1.0000000000 14 102234957 102235063 107 - 0.160 0.169 0.090
ENSG00000080823 E046 6.9599051 0.0069192257 7.931703e-01 0.8677639205 14 102235365 102235401 37 - 0.860 0.895 0.136
ENSG00000080823 E047 5.1551927 0.0035169545 7.388119e-01 0.8286014503 14 102235402 102235569 168 - 0.803 0.759 -0.175
ENSG00000080823 E048 0.5149111 0.0202350429 1.000000e+00 1.0000000000 14 102238022 102238317 296 - 0.160 0.169 0.091
ENSG00000080823 E049 0.0000000       14 102238318 102238364 47 -      
ENSG00000080823 E050 0.0000000       14 102238365 102238446 82 -      
ENSG00000080823 E051 0.0000000       14 102240452 102240621 170 -      
ENSG00000080823 E052 0.1482932 0.0412516160 8.769725e-01   14 102246057 102246247 191 - 0.000 0.092 9.895
ENSG00000080823 E053 0.0000000       14 102247395 102247464 70 -      
ENSG00000080823 E054 23.0333318 0.0008153529 2.678351e-02 0.0655410411 14 102250812 102250837 26 - 1.450 1.290 -0.555
ENSG00000080823 E055 29.5448313 0.0013797446 7.855168e-02 0.1571672391 14 102250838 102250894 57 - 1.526 1.410 -0.399
ENSG00000080823 E056 30.6294668 0.0006915122 6.992226e-01 0.7990254387 14 102250895 102250966 72 - 1.483 1.459 -0.084
ENSG00000080823 E057 20.3576047 0.0009685087 5.718160e-01 0.6980444941 14 102250967 102250987 21 - 1.324 1.280 -0.154
ENSG00000080823 E058 9.9276255 0.0350558553 2.442380e-01 0.3791880597 14 102250988 102250990 3 - 1.116 0.963 -0.559
ENSG00000080823 E059 1.3953098 0.0105007393 5.469000e-02 0.1174487309 14 102251444 102251466 23 - 0.565 0.233 -1.910
ENSG00000080823 E060 1.5007286 0.0819196987 4.447174e-02 0.0992406773 14 102251467 102251504 38 - 0.615 0.232 -2.141
ENSG00000080823 E061 1.2051864 0.0865538075 3.790128e-02 0.0871647593 14 102251505 102251610 106 - 0.565 0.168 -2.497
ENSG00000080823 E062 0.2966881 0.0270082040 7.923549e-02   14 102251611 102251742 132 - 0.277 0.000 -13.128
ENSG00000080823 E063 0.1515154 0.0428192775 2.650199e-01   14 102251743 102251755 13 - 0.160 0.000 -12.124
ENSG00000080823 E064 25.4501408 0.0007648694 5.100945e-01 0.6453436331 14 102251756 102251804 49 - 1.422 1.376 -0.158
ENSG00000080823 E065 0.6664396 0.5248040074 6.682770e-01 0.7753170783 14 102251805 102251916 112 - 0.278 0.170 -0.906
ENSG00000080823 E066 24.6117126 0.0008290470 1.273138e-01 0.2303935556 14 102251917 102251960 44 - 1.444 1.336 -0.374
ENSG00000080823 E067 21.2364331 0.0041629962 1.788455e-02 0.0468899998 14 102251961 102251995 35 - 1.429 1.241 -0.657
ENSG00000080823 E068 0.0000000       14 102260591 102260672 82 -      
ENSG00000080823 E069 0.0000000       14 102263537 102263545 9 -      
ENSG00000080823 E070 25.6143092 0.0008004049 9.647891e-04 0.0038379860 14 102263546 102263616 71 - 1.532 1.306 -0.779
ENSG00000080823 E071 1.2512805 0.0107973846 7.293268e-01 0.8215285456 14 102263617 102264651 1035 - 0.277 0.340 0.414
ENSG00000080823 E072 19.9741313 0.0009212166 3.901922e-03 0.0128683136 14 102265823 102265912 90 - 1.429 1.209 -0.768
ENSG00000080823 E073 0.3289534 0.0297075912 6.465676e-01   14 102277299 102277450 152 - 0.160 0.093 -0.909
ENSG00000080823 E074 4.6249588 0.0691310867 2.550150e-02 0.0629155320 14 102278606 102278694 89 - 0.956 0.579 -1.525
ENSG00000080823 E075 0.5085815 0.3097334773 1.000000e+00 1.0000000000 14 102280674 102280824 151 - 0.160 0.170 0.102
ENSG00000080823 E076 0.0000000       14 102283131 102283477 347 -      
ENSG00000080823 E077 43.8138405 0.0005393911 4.203208e-05 0.0002410396 14 102283478 102283592 115 - 1.754 1.538 -0.736
ENSG00000080823 E078 41.1746382 0.0005181677 5.310315e-05 0.0002972882 14 102304962 102305190 229 - 1.729 1.510 -0.748