ENSG00000080815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324501 ENSG00000080815 HEK293_OSMI2_2hA HEK293_TMG_2hB PSEN1 protein_coding protein_coding 21.47788 11.29373 28.5467 1.182716 0.5298282 1.33703 2.177096 2.9055272 0.895888 0.7295202 0.6664327 -1.686352 0.1164417 0.24983333 0.03133333 -0.21850000 9.487164e-02 7.762967e-20 FALSE TRUE
ENST00000357710 ENSG00000080815 HEK293_OSMI2_2hA HEK293_TMG_2hB PSEN1 protein_coding protein_coding 21.47788 11.29373 28.5467 1.182716 0.5298282 1.33703 9.118671 5.3457215 13.113975 0.5837369 0.8764253 1.293052 0.4364000 0.47513333 0.45966667 -0.01546667 9.267537e-01 7.762967e-20 FALSE TRUE
ENST00000553719 ENSG00000080815 HEK293_OSMI2_2hA HEK293_TMG_2hB PSEN1 protein_coding protein_coding 21.47788 11.29373 28.5467 1.182716 0.5298282 1.33703 1.321831 0.8822002 1.836796 0.8822002 1.0285577 1.049585 0.0528125 0.07653333 0.06376667 -0.01276667 6.747947e-01 7.762967e-20 FALSE FALSE
ENST00000553855 ENSG00000080815 HEK293_OSMI2_2hA HEK293_TMG_2hB PSEN1 protein_coding nonsense_mediated_decay 21.47788 11.29373 28.5467 1.182716 0.5298282 1.33703 4.317262 0.8422991 5.794146 0.4279293 0.7092413 2.767652 0.1801125 0.07646667 0.20226667 0.12580000 4.643920e-01 7.762967e-20 TRUE TRUE
ENST00000557293 ENSG00000080815 HEK293_OSMI2_2hA HEK293_TMG_2hB PSEN1 protein_coding protein_coding 21.47788 11.29373 28.5467 1.182716 0.5298282 1.33703 1.297310 0.0000000 3.564960 0.0000000 0.3713100 8.481783 0.0466500 0.00000000 0.12476667 0.12476667 7.762967e-20 7.762967e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080815 E001 0.0000000       14 73136418 73136434 17 +      
ENSG00000080815 E002 0.0000000       14 73136435 73136435 1 +      
ENSG00000080815 E003 0.0000000       14 73136436 73136436 1 +      
ENSG00000080815 E004 0.3268771 0.0268497770 7.119028e-01   14 73136437 73136443 7 + 0.096 0.155 0.787
ENSG00000080815 E005 0.4751703 0.0220445868 3.185314e-01 4.614968e-01 14 73136444 73136444 1 + 0.096 0.268 1.785
ENSG00000080815 E006 0.4751703 0.0220445868 3.185314e-01 4.614968e-01 14 73136445 73136446 2 + 0.096 0.268 1.785
ENSG00000080815 E007 0.4751703 0.0220445868 3.185314e-01 4.614968e-01 14 73136447 73136448 2 + 0.096 0.268 1.785
ENSG00000080815 E008 0.1515154 0.0436783313 8.162265e-01   14 73136449 73136450 2 + 0.096 0.000 -11.754
ENSG00000080815 E009 1.6777167 0.0841466703 5.618459e-02 1.200244e-01 14 73136451 73136455 5 + 0.542 0.155 -2.538
ENSG00000080815 E010 12.9976859 0.0021408177 5.084825e-01 6.438817e-01 14 73136456 73136476 21 + 1.158 1.113 -0.162
ENSG00000080815 E011 20.8345659 0.0279012546 1.483785e-01 2.594716e-01 14 73136477 73136495 19 + 1.390 1.236 -0.539
ENSG00000080815 E012 25.1254631 0.0122393425 5.807993e-02 1.233431e-01 14 73136496 73136506 11 + 1.470 1.314 -0.541
ENSG00000080815 E013 28.1401749 0.0112815937 1.327865e-02 3.656769e-02 14 73136507 73136517 11 + 1.531 1.332 -0.690
ENSG00000080815 E014 59.7330579 0.0008163795 6.239881e-07 5.416140e-06 14 73136518 73136540 23 + 1.860 1.632 -0.770
ENSG00000080815 E015 73.8945513 0.0004047961 1.736241e-06 1.369154e-05 14 73136541 73136579 39 + 1.940 1.752 -0.631
ENSG00000080815 E016 55.7281491 0.0003906049 1.385248e-05 8.905909e-05 14 73136580 73136583 4 + 1.822 1.628 -0.659
ENSG00000080815 E017 1.9250859 0.0074348303 7.744132e-02 1.553529e-01 14 73136817 73137124 308 + 0.571 0.268 -1.675
ENSG00000080815 E018 1.6273536 0.0083638193 3.145752e-02 7.479991e-02 14 73137125 73137223 99 + 0.541 0.154 -2.537
ENSG00000080815 E019 0.8920389 0.0141301999 8.148978e-01 8.827158e-01 14 73138107 73138111 5 + 0.299 0.268 -0.217
ENSG00000080815 E020 3.2483870 0.0049523961 6.711363e-01 7.774440e-01 14 73138112 73138152 41 + 0.650 0.601 -0.215
ENSG00000080815 E021 0.1482932 0.0411597534 2.983454e-01   14 73139297 73139398 102 + 0.000 0.154 11.853
ENSG00000080815 E022 0.4720498 0.1852249794 9.680637e-01 9.840308e-01 14 73146078 73146126 49 + 0.175 0.155 -0.208
ENSG00000080815 E023 0.1817044 0.0411674253 2.949361e-01   14 73147492 73147752 261 + 0.000 0.155 11.857
ENSG00000080815 E024 0.7394793 0.0156798796 3.989658e-01 5.427192e-01 14 73147753 73147794 42 + 0.299 0.154 -1.215
ENSG00000080815 E025 108.6849296 0.0003487619 2.334813e-05 1.425332e-04 14 73147795 73147876 82 + 2.087 1.957 -0.435
ENSG00000080815 E026 0.1482932 0.0411597534 2.983454e-01   14 73147943 73147966 24 + 0.000 0.154 11.853
ENSG00000080815 E027 57.1368941 0.0003975273 1.735165e-01 2.927619e-01 14 73147967 73147977 11 + 1.780 1.735 -0.150
ENSG00000080815 E028 77.6303101 0.0003693730 1.614607e-02 4.305172e-02 14 73147978 73148019 42 + 1.923 1.844 -0.267
ENSG00000080815 E029 112.6373286 0.0023291302 9.788890e-03 2.824405e-02 14 73148020 73148094 75 + 2.087 1.997 -0.301
ENSG00000080815 E030 26.1231740 0.0007444027 9.753360e-01 9.886390e-01 14 73148095 73148106 12 + 1.424 1.446 0.076
ENSG00000080815 E031 0.7490443 0.0784742682 7.422317e-02 1.502908e-01 14 73160009 73160138 130 + 0.350 0.000 -13.843
ENSG00000080815 E032 0.4439371 0.0215517978 2.004696e-01 3.267941e-01 14 73167829 73169461 1633 + 0.241 0.000 -13.584
ENSG00000080815 E033 212.1032507 0.0002128112 5.024708e-02 1.095970e-01 14 73170797 73171047 251 + 2.338 2.309 -0.095
ENSG00000080815 E034 0.0000000       14 73171048 73171050 3 +      
ENSG00000080815 E035 158.3525218 0.0003041502 2.802375e-01 4.200768e-01 14 73173566 73173707 142 + 2.205 2.194 -0.037
ENSG00000080815 E036 1.1384763 0.0241460767 7.830537e-01 8.607221e-01 14 73173708 73174204 497 + 0.299 0.358 0.372
ENSG00000080815 E037 115.4872944 0.0071823946 7.407083e-01 8.300600e-01 14 73186853 73186920 68 + 2.064 2.065 0.004
ENSG00000080815 E038 218.3886110 0.0002284689 5.964513e-01 7.183922e-01 14 73192644 73192864 221 + 2.336 2.343 0.023
ENSG00000080815 E039 0.6203429 0.0335111301 6.286104e-01 7.441255e-01 14 73197710 73198030 321 + 0.175 0.268 0.784
ENSG00000080815 E040 155.2423232 0.0012239851 2.933099e-01 4.343421e-01 14 73198031 73198129 99 + 2.197 2.179 -0.059
ENSG00000080815 E041 0.1515154 0.0436783313 8.162265e-01   14 73206153 73206385 233 + 0.096 0.000 -11.754
ENSG00000080815 E042 188.9285957 0.0018177642 2.071617e-01 3.351240e-01 14 73206386 73206472 87 + 2.286 2.260 -0.085
ENSG00000080815 E043 1.0393897 0.0118981090 2.062430e-02 5.279516e-02 14 73208824 73208915 92 + 0.437 0.000 -14.968
ENSG00000080815 E044 235.0778056 0.0002694072 3.706124e-01 5.150220e-01 14 73211769 73211942 174 + 2.371 2.370 -0.005
ENSG00000080815 E045 191.6264581 0.0027897283 1.135177e-01 2.106519e-01 14 73217126 73217244 119 + 2.251 2.327 0.253
ENSG00000080815 E046 1190.8963848 0.0006582029 1.512622e-17 7.236406e-16 14 73219134 73223691 4558 + 3.023 3.139 0.385