ENSG00000080802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361528 ENSG00000080802 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT4 protein_coding protein_coding 13.83414 12.49912 15.8725 0.5063041 0.5171455 0.3444567 0.2682816 0.000000 0.7622047 0.00000000 0.7622047 6.2709114 0.01692917 0.0000000 0.05106667 0.05106667 8.857271e-01 9.307373e-06 FALSE TRUE
ENST00000423368 ENSG00000080802 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT4 protein_coding protein_coding 13.83414 12.49912 15.8725 0.5063041 0.5171455 0.3444567 4.5990112 4.853631 4.4747543 0.30028874 0.2801312 -0.1170050 0.34265833 0.3876000 0.28156667 -0.10603333 4.640636e-03 9.307373e-06 FALSE TRUE
ENST00000451834 ENSG00000080802 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT4 protein_coding protein_coding 13.83414 12.49912 15.8725 0.5063041 0.5171455 0.3444567 6.3087841 7.025413 6.1281608 0.08286721 0.1784875 -0.1968287 0.46650417 0.5634667 0.38640000 -0.17706667 9.307373e-06 9.307373e-06 FALSE TRUE
MSTRG.30753.9 ENSG00000080802 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT4 protein_coding   13.83414 12.49912 15.8725 0.5063041 0.5171455 0.3444567 0.9568414 0.000000 1.8476316 0.00000000 0.9311054 7.5373206 0.05861667 0.0000000 0.11293333 0.11293333 1.993806e-01 9.307373e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080802 E001 4.1253549 0.0172390743 5.629633e-03 1.762984e-02 7 135361795 135361797 3 - 0.439 0.896 1.971
ENSG00000080802 E002 450.6110777 0.0032391988 1.941965e-38 6.080982e-36 7 135361798 135362884 1087 - 2.413 2.813 1.332
ENSG00000080802 E003 73.9109599 0.0003628013 5.738775e-04 2.436103e-03 7 135362885 135362998 114 - 1.776 1.956 0.606
ENSG00000080802 E004 99.5926208 0.0002851547 7.684328e-05 4.131376e-04 7 135362999 135363186 188 - 1.904 2.082 0.599
ENSG00000080802 E005 68.4460971 0.0004143479 3.509108e-02 8.181826e-02 7 135363854 135364066 213 - 1.769 1.898 0.434
ENSG00000080802 E006 6.1948546 0.0026061547 1.567575e-05 9.960834e-05 7 135384290 135384723 434 - 1.050 0.502 -2.230
ENSG00000080802 E007 9.5878573 0.0199266932 1.313469e-02 3.621968e-02 7 135384724 135384731 8 - 1.132 0.857 -1.018
ENSG00000080802 E008 13.7512546 0.0012530645 1.727040e-08 2.037758e-07 7 135386151 135387069 919 - 1.348 0.833 -1.875
ENSG00000080802 E009 8.8807373 0.0019111313 2.943181e-06 2.206477e-05 7 135387070 135387581 512 - 1.176 0.665 -1.949
ENSG00000080802 E010 47.5481540 0.0038535888 4.101004e-09 5.426197e-08 7 135387582 135388894 1313 - 1.809 1.494 -1.068
ENSG00000080802 E011 193.6345296 0.0039932787 8.939010e-01 9.361559e-01 7 135393918 135394299 382 - 2.264 2.310 0.154
ENSG00000080802 E012 118.1794404 0.0003424992 1.450915e-02 3.938382e-02 7 135394300 135394415 116 - 2.096 2.056 -0.133
ENSG00000080802 E013 164.7824055 0.0002474351 2.120409e-03 7.597271e-03 7 135395634 135395883 250 - 2.238 2.194 -0.148
ENSG00000080802 E014 67.6263825 0.0022674592 2.788787e-01 4.185534e-01 7 135398169 135398226 58 - 1.844 1.833 -0.038
ENSG00000080802 E015 15.4120768 0.0012439669 4.791330e-01 6.175229e-01 7 135410515 135410523 9 - 1.224 1.201 -0.083
ENSG00000080802 E016 85.3752564 0.0025436023 9.308822e-02 1.799537e-01 7 135410524 135410648 125 - 1.954 1.921 -0.113
ENSG00000080802 E017 83.8109753 0.0003323297 1.970065e-03 7.132512e-03 7 135413488 135413613 126 - 1.967 1.888 -0.266
ENSG00000080802 E018 87.8237313 0.0003690609 3.103678e-03 1.057104e-02 7 135414331 135414432 102 - 1.982 1.910 -0.242
ENSG00000080802 E019 79.3670077 0.0011954646 2.087028e-03 7.493814e-03 7 135415176 135415262 87 - 1.944 1.854 -0.303
ENSG00000080802 E020 60.3802882 0.0046091658 3.881776e-04 1.729070e-03 7 135422156 135422220 65 - 1.855 1.698 -0.532
ENSG00000080802 E021 66.8526807 0.0028016020 1.766070e-04 8.637135e-04 7 135422221 135422275 55 - 1.892 1.746 -0.495
ENSG00000080802 E022 62.8060493 0.0014758822 2.191532e-05 1.346018e-04 7 135422276 135422313 38 - 1.872 1.709 -0.551
ENSG00000080802 E023 64.8477295 0.0158628674 9.063401e-04 3.636012e-03 7 135422314 135422353 40 - 1.903 1.698 -0.693
ENSG00000080802 E024 109.0862801 0.0019920749 4.561307e-07 4.065709e-06 7 135438158 135438423 266 - 2.109 1.950 -0.533
ENSG00000080802 E025 0.1482932 0.0417027669 4.339885e-01   7 135509071 135509157 87 - 0.000 0.134 8.623
ENSG00000080802 E026 0.9535628 0.0175420307 8.778971e-01 9.255764e-01 7 135509555 135509888 334 - 0.273 0.320 0.314
ENSG00000080802 E027 65.8771703 0.0004097805 5.314091e-05 2.974908e-04 7 135509889 135510127 239 - 1.884 1.747 -0.463