ENSG00000080561

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262843 ENSG00000080561 HEK293_OSMI2_2hA HEK293_TMG_2hB MID2 protein_coding protein_coding 8.442531 7.438516 12.32354 0.4074128 0.4690605 0.7275623 2.5933082 2.3320063 3.497781 0.1915842 0.2968890 0.58281387 0.30720417 0.31393333 0.2829000 -0.03103333 7.553544e-01 2.501457e-09 FALSE TRUE
ENST00000443968 ENSG00000080561 HEK293_OSMI2_2hA HEK293_TMG_2hB MID2 protein_coding protein_coding 8.442531 7.438516 12.32354 0.4074128 0.4690605 0.7275623 3.6863754 4.5368477 4.331914 0.3124181 0.4767553 -0.06653544 0.44260833 0.61110000 0.3546667 -0.25643333 8.027485e-03 2.501457e-09 FALSE TRUE
ENST00000451923 ENSG00000080561 HEK293_OSMI2_2hA HEK293_TMG_2hB MID2 protein_coding protein_coding 8.442531 7.438516 12.32354 0.4074128 0.4690605 0.7275623 0.6356689 0.0000000 1.440695 0.0000000 0.3470668 7.18060064 0.07044167 0.00000000 0.1168000 0.11680000 2.501457e-09 2.501457e-09 FALSE FALSE
ENST00000474517 ENSG00000080561 HEK293_OSMI2_2hA HEK293_TMG_2hB MID2 protein_coding retained_intron 8.442531 7.438516 12.32354 0.4074128 0.4690605 0.7275623 1.0938681 0.1711191 2.180820 0.1711191 0.3184543 3.59646064 0.12678333 0.02193333 0.1755333 0.15360000 5.423781e-02 2.501457e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080561 E001 0.8105550 0.0148536346 2.097491e-01 0.3382490747 X 107825732 107825754 23 + 0.337 0.134 -1.701
ENSG00000080561 E002 0.6653823 0.0170622388 3.660817e-01 0.5104220536 X 107825755 107825767 13 + 0.274 0.134 -1.286
ENSG00000080561 E003 1.4643092 0.0112753984 4.040770e-01 0.5477876848 X 107825768 107825800 33 + 0.441 0.319 -0.701
ENSG00000080561 E004 0.3268771 0.0289467618 9.384895e-01   X 107825801 107825865 65 + 0.112 0.134 0.298
ENSG00000080561 E005 17.3038855 0.0225239053 8.207195e-01 0.8869427807 X 107825866 107825950 85 + 1.255 1.272 0.057
ENSG00000080561 E006 23.3608831 0.0010495019 8.998971e-01 0.9401383027 X 107825951 107825998 48 + 1.362 1.413 0.177
ENSG00000080561 E007 53.8870949 0.0006785178 2.976926e-03 0.0101946810 X 107825999 107826413 415 + 1.787 1.687 -0.338
ENSG00000080561 E008 19.1357395 0.0011846114 1.204514e-02 0.0336411833 X 107826414 107826430 17 + 1.373 1.218 -0.543
ENSG00000080561 E009 0.0000000       X 107827062 107827110 49 +      
ENSG00000080561 E010 69.2351237 0.0004685430 3.031198e-05 0.0001801856 X 107840670 107840904 235 + 1.906 1.772 -0.454
ENSG00000080561 E011 103.7075646 0.0003823067 2.472468e-05 0.0001501769 X 107840905 107841184 280 + 2.069 1.967 -0.344
ENSG00000080561 E012 111.1306419 0.0064815364 3.306689e-03 0.0111673255 X 107841185 107841385 201 + 2.098 1.997 -0.337
ENSG00000080561 E013 92.2321941 0.0065652955 2.628107e-03 0.0091535548 X 107854609 107854704 96 + 2.023 1.911 -0.375
ENSG00000080561 E014 92.5415752 0.0116020710 2.284961e-02 0.0574254691 X 107903958 107904065 108 + 2.017 1.923 -0.314
ENSG00000080561 E015 89.6500510 0.0003089718 1.644205e-01 0.2809326935 X 107905478 107905626 149 + 1.964 1.956 -0.025
ENSG00000080561 E016 76.0799571 0.0003652590 6.344387e-01 0.7488970207 X 107916002 107916129 128 + 1.877 1.901 0.082
ENSG00000080561 E017 0.0000000       X 107917502 107917505 4 +      
ENSG00000080561 E018 94.0896461 0.0003275140 1.664616e-01 0.2836041047 X 107917506 107917649 144 + 1.980 1.973 -0.022
ENSG00000080561 E019 18.3728416 0.0121768467 7.787893e-01 0.8576868910 X 107917650 107917739 90 + 1.249 1.314 0.227
ENSG00000080561 E020 122.1165972 0.0002643984 5.522592e-01 0.6815601615 X 107924343 107924504 162 + 2.059 2.121 0.208
ENSG00000080561 E021 147.9015066 0.0002675675 3.558175e-04 0.0016026379 X 107926094 107926301 208 + 2.096 2.242 0.489
ENSG00000080561 E022 1.1167064 0.0132124284 3.163668e-01 0.4591196269 X 107926302 107926472 171 + 0.392 0.236 -1.025
ENSG00000080561 E023 985.2766386 0.0070876738 1.102847e-03 0.0043124822 X 107926671 107931637 4967 + 2.931 3.050 0.397