ENSG00000080546

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356644 ENSG00000080546 HEK293_OSMI2_2hA HEK293_TMG_2hB SESN1 protein_coding protein_coding 9.913496 4.797906 13.46684 0.2304291 0.424315 1.487001 6.962708 3.8886932 8.650995 0.2747112 0.3796287 1.151542 0.7239250 0.8102667 0.6419667 -0.1683000 0.01286262 0.005379245 FALSE TRUE
MSTRG.28765.4 ENSG00000080546 HEK293_OSMI2_2hA HEK293_TMG_2hB SESN1 protein_coding   9.913496 4.797906 13.46684 0.2304291 0.424315 1.487001 2.337398 0.7064541 3.725500 0.1601432 0.1191890 2.382355 0.2134208 0.1486667 0.2767000 0.1280333 0.04613318 0.005379245 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080546 E001 0.2965864 0.0816880258 6.223558e-02   6 108984309 108986441 2133 - 0.000 0.299 11.477
ENSG00000080546 E002 197.0500820 0.0005347807 4.300894e-16 1.703159e-14 6 108986442 108987468 1027 - 2.198 2.397 0.663
ENSG00000080546 E003 59.8908845 0.0009645181 2.196356e-02 5.559694e-02 6 108987469 108987630 162 - 1.721 1.833 0.376
ENSG00000080546 E004 1.4875932 0.0095260755 1.557341e-02 4.178650e-02 6 108988363 108988542 180 - 0.494 0.000 -15.161
ENSG00000080546 E005 52.6524281 0.0014648429 1.531440e-01 2.659469e-01 6 108988543 108988687 145 - 1.685 1.763 0.264
ENSG00000080546 E006 77.3208633 0.0004113996 8.974994e-01 9.385633e-01 6 108990645 108990835 191 - 1.877 1.875 -0.005
ENSG00000080546 E007 43.2678576 0.0005647740 5.582679e-01 6.865445e-01 6 108992787 108992818 32 - 1.637 1.608 -0.099
ENSG00000080546 E008 47.4151656 0.0004543685 5.115151e-01 6.465227e-01 6 108992819 108992899 81 - 1.675 1.644 -0.107
ENSG00000080546 E009 0.0000000       6 108992900 108993016 117 -      
ENSG00000080546 E010 68.2992277 0.0030744821 8.455271e-01 9.039328e-01 6 108994462 108994609 148 - 1.815 1.826 0.037
ENSG00000080546 E011 92.0050902 0.0004504041 8.508674e-02 1.675442e-01 6 108998513 108998755 243 - 1.965 1.901 -0.215
ENSG00000080546 E012 1.3964557 0.0101682529 6.121769e-01 7.311689e-01 6 108998756 108998875 120 - 0.395 0.301 -0.565
ENSG00000080546 E013 2.2779742 0.0148156642 1.421042e-01 2.508979e-01 6 108999939 109000490 552 - 0.574 0.301 -1.458
ENSG00000080546 E014 67.0859150 0.0015880909 1.437845e-02 3.908394e-02 6 109000491 109000673 183 - 1.844 1.725 -0.401
ENSG00000080546 E015 49.1677787 0.0006134196 4.708363e-03 1.512044e-02 6 109001288 109001488 201 - 1.721 1.569 -0.519
ENSG00000080546 E016 31.4220203 0.0007527404 1.144794e-05 7.505462e-05 6 109002278 109002343 66 - 1.570 1.256 -1.089
ENSG00000080546 E017 0.1472490 0.0443701126 1.000000e+00   6 109008750 109008988 239 - 0.083 0.000 -11.876
ENSG00000080546 E018 9.1048131 0.0019333911 7.751981e-03 2.315591e-02 6 109009359 109009555 197 - 1.072 0.741 -1.261
ENSG00000080546 E019 0.1482932 0.0407689586 2.053443e-01   6 109088102 109088243 142 - 0.000 0.176 12.888
ENSG00000080546 E020 0.1482932 0.0407689586 2.053443e-01   6 109090595 109090659 65 - 0.000 0.176 12.888
ENSG00000080546 E021 75.1307657 0.0004082255 1.016312e-06 8.416564e-06 6 109093795 109094846 1052 - 1.921 1.704 -0.733