ENSG00000080345

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243326 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding protein_coding 9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 3.4239287 0.1120026 7.2869773 0.02538364 0.34231739 5.902315 0.26241250 0.07546667 0.435733333 0.36026667 3.594611e-11 6.458799e-40 FALSE TRUE
ENST00000444746 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding protein_coding 9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 0.6874904 1.0517684 0.0000000 0.09711271 0.00000000 -6.730325 0.29675000 0.69190000 0.000000000 -0.69190000 6.458799e-40 6.458799e-40 FALSE TRUE
ENST00000457745 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding processed_transcript 9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 0.0707596 0.1076958 0.0639226 0.05442421 0.04252528 -0.670975 0.02136250 0.07070000 0.003866667 -0.06683333 1.115050e-01 6.458799e-40   FALSE
ENST00000467762 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding processed_transcript 9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 0.1420089 0.1065823 0.0000000 0.06334748 0.00000000 -3.543277 0.03730417 0.07310000 0.000000000 -0.07310000 3.454957e-03 6.458799e-40 FALSE TRUE
MSTRG.19338.14 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding   9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 0.4143112 0.0000000 1.1178647 0.00000000 0.58441163 6.817450 0.02786667 0.00000000 0.066200000 0.06620000 5.547112e-01 6.458799e-40 TRUE TRUE
MSTRG.19338.2 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding   9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 2.7456348 0.0000000 4.8118289 0.00000000 1.01158954 8.913437 0.15634167 0.00000000 0.289366667 0.28936667 1.351747e-06 6.458799e-40 TRUE TRUE
MSTRG.19338.7 ENSG00000080345 HEK293_OSMI2_2hA HEK293_TMG_2hB RIF1 protein_coding   9.680149 1.514611 16.7081 0.06216084 0.3231572 3.454898 0.8111310 0.0000000 1.5449629 0.00000000 0.91345010 7.280736 0.04673333 0.00000000 0.093400000 0.09340000 5.383391e-01 6.458799e-40 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080345 E001 0.0000000       2 151409873 151409882 10 +      
ENSG00000080345 E002 0.0000000       2 151409883 151409885 3 +      
ENSG00000080345 E003 0.0000000       2 151409886 151409894 9 +      
ENSG00000080345 E004 0.1515154 0.0423045958 5.549994e-01   2 151409895 151409896 2 + 0.035 0.000 -10.422
ENSG00000080345 E005 0.1515154 0.0423045958 5.549994e-01   2 151409897 151409899 3 + 0.035 0.000 -10.374
ENSG00000080345 E006 0.1515154 0.0423045958 5.549994e-01   2 151409900 151409901 2 + 0.035 0.000 -10.374
ENSG00000080345 E007 0.2987644 0.0290785164 1.000000e+00   2 151409902 151409910 9 + 0.068 0.000 -11.374
ENSG00000080345 E008 5.1883125 0.0198380395 9.678551e-01 9.839104e-01 2 151409911 151409939 29 + 0.559 0.678 0.520
ENSG00000080345 E009 2.9862335 0.0052288364 5.347322e-01 6.667418e-01 2 151409940 151409940 1 + 0.416 0.353 -0.361
ENSG00000080345 E010 3.7352778 0.0042290241 3.618248e-01 5.062453e-01 2 151409941 151409955 15 + 0.482 0.353 -0.698
ENSG00000080345 E011 11.9275443 0.0014791926 8.218046e-02 1.629486e-01 2 151409956 151410033 78 + 0.876 0.677 -0.795
ENSG00000080345 E012 11.0033658 0.0117373756 4.222526e-02 9.513640e-02 2 151410034 151410089 56 + 0.851 0.545 -1.282
ENSG00000080345 E013 28.8475176 0.0006433214 4.739940e-04 2.060693e-03 2 151410090 151410413 324 + 1.230 0.861 -1.353
ENSG00000080345 E014 28.2677572 0.0006571056 2.176885e-03 7.770369e-03 2 151410414 151410527 114 + 1.219 0.930 -1.052
ENSG00000080345 E015 26.7875389 0.0007293594 1.235781e-03 4.762016e-03 2 151411260 151411338 79 + 1.199 0.861 -1.242
ENSG00000080345 E016 31.2216103 0.0006464612 2.052931e-03 7.390295e-03 2 151414823 151414919 97 + 1.257 0.990 -0.964
ENSG00000080345 E017 36.2808216 0.0009256557 6.280314e-05 3.451659e-04 2 151416561 151416688 128 + 1.325 0.930 -1.423
ENSG00000080345 E018 37.1252698 0.0005825529 1.566094e-06 1.246604e-05 2 151416807 151416901 95 + 1.339 0.779 -2.056
ENSG00000080345 E019 31.9613952 0.0005894179 3.633449e-06 2.670285e-05 2 151420190 151420224 35 + 1.277 0.677 -2.256
ENSG00000080345 E020 54.6652229 0.0005500298 1.994719e-07 1.911168e-06 2 151420225 151420379 155 + 1.497 1.042 -1.601
ENSG00000080345 E021 37.8094575 0.0062420784 7.653530e-05 4.116570e-04 2 151422950 151423042 93 + 1.342 0.930 -1.482
ENSG00000080345 E022 0.0000000       2 151423233 151423760 528 +      
ENSG00000080345 E023 41.9384372 0.0104839227 4.896086e-03 1.564137e-02 2 151428784 151428922 139 + 1.378 1.169 -0.735
ENSG00000080345 E024 49.6788149 0.0076118044 3.218488e-04 1.468245e-03 2 151433077 151433228 152 + 1.451 1.169 -0.987
ENSG00000080345 E025 53.2517241 0.0004919636 1.934418e-05 1.204185e-04 2 151435463 151435580 118 + 1.481 1.169 -1.088
ENSG00000080345 E026 68.8106956 0.0018017413 4.650408e-06 3.334731e-05 2 151436827 151437003 177 + 1.589 1.296 -1.010
ENSG00000080345 E027 58.6042821 0.0170316105 4.651375e-04 2.026607e-03 2 151437241 151437351 111 + 1.520 1.239 -0.975
ENSG00000080345 E028 39.8968493 0.0028644134 2.262496e-04 1.075771e-03 2 151438684 151438746 63 + 1.362 1.042 -1.135
ENSG00000080345 E029 39.6414121 0.0032496526 2.870234e-04 1.327241e-03 2 151440027 151440127 101 + 1.357 1.042 -1.117
ENSG00000080345 E030 32.0055097 0.0041633510 2.066630e-03 7.430712e-03 2 151441905 151441967 63 + 1.267 0.990 -0.998
ENSG00000080345 E031 23.7745195 0.0009264878 1.612691e-01 2.767462e-01 2 151441968 151441991 24 + 1.134 1.089 -0.162
ENSG00000080345 E032 41.3871120 0.0005165016 8.262116e-05 4.404269e-04 2 151443259 151443329 71 + 1.377 1.042 -1.190
ENSG00000080345 E033 62.2980613 0.0004062170 3.459215e-05 2.025398e-04 2 151443529 151443709 181 + 1.545 1.296 -0.861
ENSG00000080345 E034 40.6011892 0.0005364179 1.434897e-01 2.527611e-01 2 151445338 151445445 108 + 1.352 1.348 -0.014
ENSG00000080345 E035 40.2346599 0.0005729298 3.069202e-02 7.331596e-02 2 151446426 151446575 150 + 1.354 1.268 -0.300
ENSG00000080345 E036 30.5187126 0.0020461258 3.146408e-03 1.069677e-02 2 151451606 151451705 100 + 1.247 0.990 -0.927
ENSG00000080345 E037 75.2543767 0.0003287797 6.034683e-07 5.253677e-06 2 151454895 151455159 265 + 1.626 1.323 -1.044
ENSG00000080345 E038 35.2838658 0.0005662776 3.199839e-03 1.085563e-02 2 151456578 151456620 43 + 1.305 1.089 -0.770
ENSG00000080345 E039 71.8450535 0.0003733532 1.795365e-05 1.125464e-04 2 151457761 151457963 203 + 1.604 1.372 -0.798
ENSG00000080345 E040 50.8406965 0.0004566866 4.792679e-08 5.192489e-07 2 151458811 151458910 100 + 1.469 0.930 -1.920
ENSG00000080345 E041 54.7717495 0.0004217226 7.423658e-07 6.341945e-06 2 151460000 151460119 120 + 1.497 1.089 -1.431
ENSG00000080345 E042 65.3323235 0.0003754903 9.870593e-10 1.465481e-08 2 151461138 151461289 152 + 1.574 1.042 -1.865
ENSG00000080345 E043 51.6972148 0.0009573732 8.891358e-04 3.576004e-03 2 151462242 151462322 81 + 1.461 1.268 -0.671
ENSG00000080345 E044 49.5153455 0.0005437831 8.129283e-03 2.411179e-02 2 151462412 151462466 55 + 1.439 1.323 -0.403
ENSG00000080345 E045 50.9067536 0.0339864675 2.720454e-02 6.640750e-02 2 151462884 151462938 55 + 1.453 1.304 -0.519
ENSG00000080345 E046 457.0871889 0.0400581970 8.980538e-05 4.740814e-04 2 151462939 151464699 1761 + 2.397 2.182 -0.720
ENSG00000080345 E047 313.4546934 0.0032208878 1.694427e-04 8.327305e-04 2 151464700 151465853 1154 + 2.223 2.199 -0.079
ENSG00000080345 E048 106.3658484 0.0002782889 2.674816e-01 4.058075e-01 2 151465854 151466120 267 + 1.749 1.828 0.266
ENSG00000080345 E049 85.6215088 0.0003491951 4.560403e-01 5.965138e-01 2 151468000 151468146 147 + 1.646 1.836 0.645
ENSG00000080345 E050 37.9299693 0.0005591790 2.469760e-01 3.823806e-01 2 151468474 151468551 78 + 1.298 1.542 0.841
ENSG00000080345 E051 82.6020912 0.0003344285 4.630384e-01 6.028826e-01 2 151468641 151468756 116 + 1.630 1.820 0.645
ENSG00000080345 E052 80.6381390 0.0003494308 6.544760e-01 7.646437e-01 2 151469711 151469864 154 + 1.622 1.795 0.586
ENSG00000080345 E053 54.3113954 0.0010265278 2.139361e-01 3.431722e-01 2 151473964 151474072 109 + 1.450 1.686 0.808
ENSG00000080345 E054 131.9595564 0.0002450230 6.069621e-05 3.348782e-04 2 151474857 151475219 363 + 1.813 2.142 1.106
ENSG00000080345 E055 494.3613827 0.0064384034 1.035075e-16 4.443506e-15 2 151475220 151480097 4878 + 2.359 2.829 1.565
ENSG00000080345 E056 28.5022705 0.0006752719 7.824645e-05 4.196929e-04 2 151480098 151480227 130 + 1.139 1.627 1.693
ENSG00000080345 E057 262.1193583 0.0539619815 6.604676e-10 1.013475e-08 2 151480228 151482172 1945 + 1.992 2.812 2.738
ENSG00000080345 E058 3.3729092 0.0238808491 1.498687e-01 2.615006e-01 2 151483199 151483335 137 + 0.387 0.781 1.806
ENSG00000080345 E059 0.8407440 0.0158093453 5.665820e-02 1.208617e-01 2 151486277 151486651 375 + 0.098 0.545 3.304
ENSG00000080345 E060 0.5138669 0.0215106106 1.914704e-01 3.155835e-01 2 151486652 151486756 105 + 0.068 0.353 2.889
ENSG00000080345 E061 0.8899506 0.0134416361 8.772620e-01 9.251625e-01 2 151494975 151495228 254 + 0.178 0.000 -12.959
ENSG00000080345 E062 1.5469244 0.0095395199 4.673660e-03 1.502224e-02 2 151495229 151495326 98 + 0.153 0.779 3.567
ENSG00000080345 E063 1.7715032 0.2384800012 1.684485e-03 6.233434e-03 2 151497786 151498215 430 + 0.127 0.942 4.511
ENSG00000080345 E064 0.4460135 0.0296589210 1.000000e+00 1.000000e+00 2 151499345 151499540 196 + 0.098 0.000 -11.959
ENSG00000080345 E065 0.6631923 0.5192324057 3.121446e-01 4.546702e-01 2 151503034 151503185 152 + 0.098 0.361 2.352
ENSG00000080345 E066 1.1467936 0.0112607721 5.782922e-05 3.207886e-04 2 151505948 151506209 262 + 0.068 0.860 5.207
ENSG00000080345 E067 2.9214834 0.0342882296 2.430067e-02 6.043569e-02 2 151506210 151506375 166 + 0.322 0.863 2.516
ENSG00000080345 E068 0.3030308 0.2983666458 1.000000e+00   2 151506996 151507112 117 + 0.068 0.000 -11.379
ENSG00000080345 E069 1.1426289 0.0112394335 1.620568e-02 4.317724e-02 2 151507729 151508013 285 + 0.127 0.677 3.472
ENSG00000080345 E070 1.2814720 0.1277858773 4.417841e-02 9.871984e-02 2 151533933 151534014 82 + 0.153 0.679 3.157