ENSG00000080189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317734 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding protein_coding 70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 6.937013 16.308907 3.702542 1.281504 0.06613762 -2.13606538 0.08383750 0.13906667 0.08456667 -0.054500000 5.305598e-07 5.305598e-07 FALSE  
ENST00000480329 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding processed_transcript 70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 4.495107 4.422434 4.538732 2.214980 0.71974618 0.03736529 0.06900833 0.03523333 0.10256667 0.067333333 5.776164e-01 5.305598e-07 FALSE  
ENST00000484318 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding processed_transcript 70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 11.022761 17.998714 6.485198 1.577093 0.10600550 -1.47124986 0.15816250 0.15316667 0.14843333 -0.004733333 9.011216e-01 5.305598e-07 FALSE  
MSTRG.20794.10 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding   70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 3.774574 5.166487 1.931240 0.252918 0.68975489 -1.41499488 0.05550000 0.04480000 0.04430000 -0.000500000 9.235881e-01 5.305598e-07 FALSE  
MSTRG.20794.12 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding   70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 4.736446 5.738244 5.503815 1.771441 0.51701511 -0.06007038 0.07158333 0.05040000 0.12620000 0.075800000 1.091604e-01 5.305598e-07 FALSE  
MSTRG.20794.16 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding   70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 8.626445 21.219876 3.387172 1.864112 1.82956182 -2.64368959 0.10918750 0.18063333 0.07473333 -0.105900000 6.061687e-01 5.305598e-07 FALSE  
MSTRG.20794.8 ENSG00000080189 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C2 protein_coding   70.44924 117.2531 43.90994 8.668742 2.012024 -1.416801 17.113592 29.073076 9.115248 4.201955 0.91258173 -1.67224421 0.23856667 0.24583333 0.21000000 -0.035833333 6.943194e-01 5.305598e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000080189 E001 0.693495 0.0768528884 3.161044e-01 4.588677e-01 20 46345980 46345983 4 - 0.326 0.140 -1.556
ENSG00000080189 E002 218.235794 0.0002347723 1.587223e-54 1.290535e-51 20 46345984 46349527 3544 - 2.528 2.134 -1.317
ENSG00000080189 E003 6.368884 0.0060005817 2.858472e-02 6.917846e-02 20 46349528 46349529 2 - 0.998 0.713 -1.106
ENSG00000080189 E004 185.743129 0.0022578446 3.530407e-01 4.972825e-01 20 46349530 46349903 374 - 2.159 2.197 0.124
ENSG00000080189 E005 157.655775 0.0017682971 4.265087e-03 1.388473e-02 20 46349904 46349936 33 - 2.024 2.141 0.391
ENSG00000080189 E006 219.759121 0.0001996346 5.027186e-05 2.831699e-04 20 46349937 46349983 47 - 2.161 2.283 0.407
ENSG00000080189 E007 305.358495 0.0001961993 4.719006e-04 2.052628e-03 20 46349984 46350047 64 - 2.328 2.417 0.297
ENSG00000080189 E008 247.178653 0.0002292997 2.279560e-02 5.731712e-02 20 46350048 46350060 13 - 2.257 2.321 0.213
ENSG00000080189 E009 378.789362 0.0005233085 1.496527e-05 9.555206e-05 20 46350061 46350109 49 - 2.408 2.516 0.360
ENSG00000080189 E010 334.252803 0.0002228117 1.194582e-03 4.622345e-03 20 46350110 46350139 30 - 2.377 2.457 0.264
ENSG00000080189 E011 392.378721 0.0008885644 2.468630e-03 8.669792e-03 20 46350140 46350197 58 - 2.447 2.527 0.267
ENSG00000080189 E012 680.998125 0.0001275381 8.004099e-06 5.435345e-05 20 46350198 46350354 157 - 2.688 2.763 0.252
ENSG00000080189 E013 746.102074 0.0002754192 1.089479e-07 1.099151e-06 20 46350355 46350524 170 - 2.713 2.806 0.309
ENSG00000080189 E014 69.816478 0.0004858196 3.461854e-05 2.026722e-04 20 46350525 46350760 236 - 1.909 1.717 -0.649
ENSG00000080189 E015 314.336189 0.0001664106 3.422566e-01 4.862536e-01 20 46350761 46350770 10 - 2.393 2.417 0.077
ENSG00000080189 E016 667.087185 0.0001136923 3.478930e-03 1.166397e-02 20 46350771 46350890 120 - 2.699 2.748 0.164
ENSG00000080189 E017 548.075260 0.0003606301 4.035127e-02 9.166530e-02 20 46352051 46352122 72 - 2.620 2.661 0.139
ENSG00000080189 E018 363.197821 0.0008343492 5.047445e-01 6.406427e-01 20 46352123 46352149 27 - 2.462 2.480 0.061
ENSG00000080189 E019 295.558631 0.0007564366 8.490387e-01 9.063075e-01 20 46352150 46352163 14 - 2.382 2.388 0.020
ENSG00000080189 E020 496.521232 0.0008472695 8.408327e-01 9.006538e-01 20 46352164 46352226 63 - 2.605 2.612 0.021
ENSG00000080189 E021 18.162061 0.0010298817 3.357485e-03 1.131366e-02 20 46352227 46353197 971 - 1.380 1.130 -0.879
ENSG00000080189 E022 560.539912 0.0011321298 2.143834e-01 3.437257e-01 20 46354882 46354965 84 - 2.683 2.657 -0.087
ENSG00000080189 E023 369.653346 0.0001634998 7.903449e-03 2.353518e-02 20 46355073 46355103 31 - 2.526 2.469 -0.190
ENSG00000080189 E024 401.563663 0.0001674593 3.284522e-03 1.110513e-02 20 46355104 46355169 66 - 2.564 2.503 -0.202
ENSG00000080189 E025 237.735821 0.0012022995 7.452704e-03 2.239251e-02 20 46355170 46355178 9 - 2.351 2.271 -0.268
ENSG00000080189 E026 290.614277 0.0003642876 2.321984e-03 8.219379e-03 20 46355179 46355241 63 - 2.436 2.360 -0.252
ENSG00000080189 E027 18.521628 0.0011492743 1.870021e-01 3.099609e-01 20 46355242 46355279 38 - 1.302 1.187 -0.407
ENSG00000080189 E028 10.284648 0.0016776022 1.148154e-01 2.125618e-01 20 46355280 46355339 60 - 1.106 0.933 -0.637
ENSG00000080189 E029 18.361027 0.0009804235 2.368110e-02 5.915341e-02 20 46355688 46355801 114 - 1.348 1.154 -0.685
ENSG00000080189 E030 336.047212 0.0001534308 4.728851e-03 1.517466e-02 20 46355802 46355874 73 - 2.490 2.427 -0.211
ENSG00000080189 E031 335.103673 0.0001691675 5.510952e-02 1.181875e-01 20 46356574 46356637 64 - 2.474 2.431 -0.144
ENSG00000080189 E032 319.612927 0.0001470863 1.653341e-01 2.821171e-01 20 46357623 46357702 80 - 2.444 2.412 -0.107
ENSG00000080189 E033 303.218906 0.0001823151 1.032233e-01 1.953893e-01 20 46357703 46357773 71 - 2.428 2.389 -0.129
ENSG00000080189 E034 253.344821 0.0002359837 1.718627e-01 2.906367e-01 20 46358387 46358426 40 - 2.348 2.312 -0.119
ENSG00000080189 E035 362.851912 0.0001750593 2.187042e-02 5.540856e-02 20 46358427 46358558 132 - 2.515 2.465 -0.166
ENSG00000080189 E036 366.815799 0.0001601178 3.235775e-01 4.668910e-01 20 46358559 46358690 132 - 2.496 2.475 -0.071
ENSG00000080189 E037 257.391222 0.0001731036 8.746987e-01 9.234583e-01 20 46358691 46358763 73 - 2.330 2.326 -0.013
ENSG00000080189 E038 20.215401 0.0365003225 1.240821e-01 2.257941e-01 20 46358764 46358766 3 - 1.389 1.209 -0.631
ENSG00000080189 E039 33.210637 0.0006331236 2.466411e-02 6.118935e-02 20 46358767 46358958 192 - 1.566 1.417 -0.512
ENSG00000080189 E040 7.221283 0.0022841799 4.244684e-03 1.382686e-02 20 46363086 46363174 89 - 1.086 0.743 -1.304
ENSG00000080189 E041 4.781588 0.0532007443 2.525052e-01 3.888629e-01 20 46363900 46363963 64 - 0.820 0.631 -0.772
ENSG00000080189 E042 9.791672 0.0018038379 3.585982e-03 1.197141e-02 20 46364040 46364370 331 - 1.176 0.860 -1.165
ENSG00000080189 E043 159.859377 0.0002058208 9.969046e-01 1.000000e+00 20 46364371 46364502 132 - 2.121 2.121 0.000