ENSG00000079974

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354869 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding protein_coding 26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 2.320679 7.9818290 1.5455322 1.4683432 1.1074566 -2.36111748 0.07742083 0.22026667 0.06553333 -0.15473333 3.640132e-01 8.861072e-16 FALSE  
ENST00000413505 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding protein_coding 26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 2.173405 0.9665794 2.4389605 0.3251881 0.3609931 1.32636021 0.09243750 0.02623333 0.10686667 0.08063333 3.213853e-03 8.861072e-16    
ENST00000482308 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding retained_intron 26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 1.855290 3.9231566 0.8367255 0.6134868 0.4357106 -2.21572137 0.06532500 0.10836667 0.03786667 -0.07050000 4.677964e-01 8.861072e-16    
ENST00000691320 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding protein_coding 26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 7.937913 9.5913374 8.0175696 1.4911094 0.5764091 -0.25827211 0.29862083 0.27143333 0.35463333 0.08320000 5.281491e-01 8.861072e-16 FALSE  
MSTRG.22395.18 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding   26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 3.443805 3.2827994 3.1664474 0.4260432 0.2843554 -0.05190051 0.13489583 0.09100000 0.13893333 0.04793333 6.325666e-02 8.861072e-16 FALSE  
MSTRG.22395.21 ENSG00000079974 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2B protein_coding   26.36264 35.85644 22.73165 1.88996 0.64525 -0.6572974 0.826470 0.0000000 1.9092761 0.0000000 0.4091694 7.58441842 0.03742083 0.00000000 0.08416667 0.08416667 8.861072e-16 8.861072e-16 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079974 E001 0.0000000       22 50767239 50767478 240 -      
ENSG00000079974 E002 0.6568746 0.0214017802 0.7154566064 0.8113561863 22 50767479 50767499 21 - 0.163 0.230 0.615
ENSG00000079974 E003 0.6568746 0.0214017802 0.7154566064 0.8113561863 22 50767500 50767500 1 - 0.163 0.230 0.615
ENSG00000079974 E004 0.6568746 0.0214017802 0.7154566064 0.8113561863 22 50767501 50767505 5 - 0.163 0.230 0.615
ENSG00000079974 E005 2.1983101 0.0264498782 0.0325359841 0.0768741296 22 50767506 50767506 1 - 0.163 0.578 2.611
ENSG00000079974 E006 2.4197553 0.0070573282 0.0188000235 0.0488956501 22 50767507 50767508 2 - 0.163 0.604 2.730
ENSG00000079974 E007 2.4197553 0.0070573282 0.0188000235 0.0488956501 22 50767509 50767509 1 - 0.163 0.604 2.730
ENSG00000079974 E008 2.9377869 0.0051862672 0.0059772237 0.0185478877 22 50767510 50767512 3 - 0.163 0.674 3.030
ENSG00000079974 E009 13.6095022 0.0112373560 0.1683133108 0.2860027966 22 50767513 50767525 13 - 1.024 1.179 0.560
ENSG00000079974 E010 13.8685258 0.0124612404 0.2960407033 0.4372068720 22 50767526 50767529 4 - 1.060 1.178 0.427
ENSG00000079974 E011 43.4446617 0.0005296781 0.0100460579 0.0288755640 22 50767530 50767573 44 - 1.498 1.653 0.526
ENSG00000079974 E012 43.3090409 0.0005355409 0.0113296823 0.0319529323 22 50767574 50767576 3 - 1.498 1.650 0.519
ENSG00000079974 E013 42.9790433 0.0005384231 0.0142820831 0.0388682670 22 50767577 50767578 2 - 1.498 1.646 0.503
ENSG00000079974 E014 124.1503639 0.0067867100 0.0021843367 0.0077937326 22 50767579 50767708 130 - 1.940 2.104 0.549
ENSG00000079974 E015 592.0732948 0.0009536009 0.0142714983 0.0388433666 22 50767709 50768759 1051 - 2.703 2.748 0.148
ENSG00000079974 E016 64.8318505 0.0004389745 0.6337771821 0.7483899037 22 50768760 50768874 115 - 1.759 1.784 0.083
ENSG00000079974 E017 37.4387891 0.0005941702 0.3860035450 0.5301993387 22 50769041 50769124 84 - 1.584 1.535 -0.167
ENSG00000079974 E018 5.4812120 0.0029578992 0.6582348296 0.7674245704 22 50769425 50769454 30 - 0.811 0.752 -0.231
ENSG00000079974 E019 37.8138053 0.0005904957 0.5326705673 0.6650015933 22 50769455 50769526 72 - 1.523 1.563 0.138
ENSG00000079974 E020 38.0087456 0.0006082475 0.2729826219 0.4119528651 22 50769527 50769549 23 - 1.505 1.574 0.238
ENSG00000079974 E021 26.9618437 0.0007151237 0.1493694959 0.2607977852 22 50769550 50769552 3 - 1.332 1.439 0.371
ENSG00000079974 E022 23.8623884 0.0105663823 0.6938755425 0.7948378834 22 50769553 50769781 229 - 1.332 1.368 0.124
ENSG00000079974 E023 10.4814977 0.0016612228 0.0026685982 0.0092783248 22 50769782 50769880 99 - 0.745 1.109 1.381
ENSG00000079974 E024 5.2865577 0.0095345744 0.3101526368 0.4525236945 22 50769881 50769904 24 - 0.667 0.817 0.612
ENSG00000079974 E025 100.2673052 0.0002927606 0.2097676973 0.3382662810 22 50769905 50770016 112 - 1.997 1.953 -0.147
ENSG00000079974 E026 4.4880248 0.0036751394 0.1275898101 0.2307916965 22 50770017 50770502 486 - 0.840 0.629 -0.862
ENSG00000079974 E027 27.7045003 0.0047513079 0.0005944063 0.0025129095 22 50771210 50773109 1900 - 1.584 1.339 -0.840
ENSG00000079974 E028 2.7690496 0.0060500769 0.0103632749 0.0296578648 22 50775771 50775771 1 - 0.779 0.380 -1.843
ENSG00000079974 E029 139.8966264 0.0002715212 0.0565115140 0.1206194010 22 50775772 50775851 80 - 2.149 2.092 -0.190
ENSG00000079974 E030 107.6671666 0.0003585024 0.1278384538 0.2311686192 22 50776670 50776749 80 - 2.032 1.980 -0.174
ENSG00000079974 E031 3.7590277 0.0043959143 0.4880712464 0.6256843511 22 50777660 50777951 292 - 0.707 0.605 -0.438
ENSG00000079974 E032 53.8035108 0.0005783678 0.0398074244 0.0906694216 22 50777952 50777981 30 - 1.766 1.666 -0.339
ENSG00000079974 E033 0.0000000       22 50779011 50779121 111 -      
ENSG00000079974 E034 0.3729606 0.0352968400 0.6235057243 0.7400805042 22 50780025 50780226 202 - 0.163 0.091 -0.966
ENSG00000079974 E035 0.0000000       22 50780613 50780718 106 -      
ENSG00000079974 E036 56.2212508 0.0022011458 0.1305769898 0.2349611902 22 50782188 50782233 46 - 1.770 1.692 -0.263
ENSG00000079974 E037 90.5738069 0.0101443028 0.4819565945 0.6201326516 22 50782234 50782347 114 - 1.952 1.908 -0.151
ENSG00000079974 E038 28.2920243 0.0007471027 0.0703524476 0.1439408616 22 50782348 50782351 4 - 1.505 1.385 -0.412
ENSG00000079974 E039 3.5794048 0.0049501058 0.0001073370 0.0005559262 22 50782769 50782890 122 - 0.942 0.379 -2.472
ENSG00000079974 E040 1.3973861 0.0403280739 0.0571839775 0.1217789430 22 50782891 50782894 4 - 0.572 0.230 -1.971
ENSG00000079974 E041 4.7199548 0.0034786345 0.0069346864 0.0210547868 22 50782895 50783038 144 - 0.942 0.579 -1.471
ENSG00000079974 E042 15.5469947 0.0491037727 0.3417024960 0.4856193240 22 50783039 50783044 6 - 1.252 1.143 -0.385
ENSG00000079974 E043 20.4545819 0.0009691525 0.0505436969 0.1101235380 22 50783045 50783045 1 - 1.392 1.243 -0.520
ENSG00000079974 E044 60.1871033 0.0084852520 0.0008999064 0.0036134924 22 50783046 50783286 241 - 1.876 1.671 -0.694
ENSG00000079974 E045 13.1996089 0.1055593445 0.4202435613 0.5634546057 22 50783391 50783500 110 - 1.192 1.069 -0.442
ENSG00000079974 E046 67.3900790 0.0161873937 0.3552742666 0.4996299039 22 50783501 50783667 167 - 1.837 1.772 -0.221