ENSG00000079931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367963 ENSG00000079931 HEK293_OSMI2_2hA HEK293_TMG_2hB MOXD1 protein_coding protein_coding 8.819378 8.539194 11.21874 1.2986 0.3478752 0.3933357 8.335217 8.264473 9.628589 1.418122 0.2227190 0.2201545 0.949225 0.9619667 0.8592333 -0.1027333 6.763838e-02 2.385719e-12 FALSE TRUE
ENST00000489128 ENSG00000079931 HEK293_OSMI2_2hA HEK293_TMG_2hB MOXD1 protein_coding processed_transcript 8.819378 8.539194 11.21874 1.2986 0.3478752 0.3933357 0.382132 0.000000 1.449577 0.000000 0.2907168 7.1894061 0.038000 0.0000000 0.1283333 0.1283333 2.385719e-12 2.385719e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079931 E001 0.7748771 0.0239355250 1.680975e-02 4.451434e-02 6 132296055 132296068 14 - 0.000 0.431 11.641
ENSG00000079931 E002 336.1947891 0.0038858810 7.357766e-07 6.291045e-06 6 132296069 132297317 1249 - 2.440 2.601 0.538
ENSG00000079931 E003 106.6348853 0.0002797494 4.071268e-02 9.234234e-02 6 132297787 132297955 169 - 1.989 2.080 0.305
ENSG00000079931 E004 58.6201447 0.0005159861 7.824181e-01 8.603028e-01 6 132315635 132315696 62 - 1.762 1.797 0.119
ENSG00000079931 E005 76.3658320 0.0003489611 6.894220e-01 7.913235e-01 6 132315697 132315777 81 - 1.890 1.898 0.026
ENSG00000079931 E006 75.3259106 0.0004008764 1.109652e-01 2.069646e-01 6 132320629 132320688 60 - 1.907 1.867 -0.135
ENSG00000079931 E007 112.6752475 0.0006466861 9.799934e-02 1.874659e-01 6 132322679 132322870 192 - 2.076 2.043 -0.113
ENSG00000079931 E008 88.1038106 0.0011192358 2.210203e-01 3.516437e-01 6 132323931 132324097 167 - 1.968 1.942 -0.087
ENSG00000079931 E009 0.0000000       6 132325080 132325147 68 -      
ENSG00000079931 E010 53.9866087 0.0004916673 4.875250e-02 1.069468e-01 6 132328013 132328115 103 - 1.785 1.717 -0.229
ENSG00000079931 E011 83.5727044 0.0004527425 7.756005e-03 2.316530e-02 6 132328415 132328594 180 - 1.975 1.899 -0.254
ENSG00000079931 E012 69.1809320 0.0010573178 2.344986e-02 5.868181e-02 6 132372608 132372691 84 - 1.892 1.819 -0.245
ENSG00000079931 E013 89.0032561 0.0020412148 2.507930e-02 6.203580e-02 6 132372830 132372997 168 - 1.996 1.927 -0.234
ENSG00000079931 E014 57.9732038 0.0010104828 2.070244e-02 5.296037e-02 6 132374631 132374777 147 - 1.819 1.734 -0.288
ENSG00000079931 E015 0.5880631 0.5343177660 6.302462e-01 7.454424e-01 6 132374778 132375065 288 - 0.117 0.237 1.226
ENSG00000079931 E016 4.8994070 0.0035829444 7.799781e-01 8.585537e-01 6 132390422 132392299 1878 - 0.753 0.810 0.228
ENSG00000079931 E017 57.3295266 0.0185158555 2.151239e-01 3.445731e-01 6 132401163 132401475 313 - 1.811 1.723 -0.295