ENSG00000079819

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337057 ENSG00000079819 HEK293_OSMI2_2hA HEK293_TMG_2hB EPB41L2 protein_coding protein_coding 35.26354 26.52297 44.7612 1.557858 0.4824135 0.7547847 14.7678396 13.346108 20.582650 0.8258413 0.9080949 0.6246298 0.42369167 0.50330000 0.45963333 -0.04366667 4.431700e-01 3.575446e-34 FALSE TRUE
ENST00000530481 ENSG00000079819 HEK293_OSMI2_2hA HEK293_TMG_2hB EPB41L2 protein_coding protein_coding 35.26354 26.52297 44.7612 1.557858 0.4824135 0.7547847 1.5421930 2.510883 0.000000 0.3697938 0.0000000 -7.9777855 0.05251250 0.09363333 0.00000000 -0.09363333 3.575446e-34 3.575446e-34 FALSE TRUE
ENST00000628542 ENSG00000079819 HEK293_OSMI2_2hA HEK293_TMG_2hB EPB41L2 protein_coding protein_coding 35.26354 26.52297 44.7612 1.557858 0.4824135 0.7547847 11.6143975 8.554890 12.480192 0.7631489 0.1923396 0.5442891 0.32906250 0.32133333 0.27886667 -0.04246667 1.815143e-01 3.575446e-34 FALSE TRUE
MSTRG.28960.16 ENSG00000079819 HEK293_OSMI2_2hA HEK293_TMG_2hB EPB41L2 protein_coding   35.26354 26.52297 44.7612 1.557858 0.4824135 0.7547847 0.9062906 0.000000 2.714929 0.0000000 0.2970181 8.0900749 0.02070417 0.00000000 0.06063333 0.06063333 6.978262e-21 3.575446e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079819 E001 1.9194926 0.1532073939 5.791945e-04 2.457044e-03 6 130839347 130839349 3 - 0.000 0.739 15.002
ENSG00000079819 E002 2.0677858 0.1864145657 7.358862e-04 3.028445e-03 6 130839350 130839351 2 - 0.000 0.764 15.303
ENSG00000079819 E003 2.0677858 0.1864145657 7.358862e-04 3.028445e-03 6 130839352 130839352 1 - 0.000 0.764 15.303
ENSG00000079819 E004 609.0104852 0.0132847847 2.004772e-06 1.559170e-05 6 130839353 130839883 531 - 2.631 2.915 0.943
ENSG00000079819 E005 412.4664738 0.0062538051 3.898503e-11 7.367180e-10 6 130839884 130840134 251 - 2.459 2.748 0.962
ENSG00000079819 E006 136.5676346 0.0031159543 1.218080e-08 1.478956e-07 6 130840135 130840167 33 - 2.009 2.253 0.819
ENSG00000079819 E007 142.1753774 0.0003411448 6.907461e-07 5.938185e-06 6 130840168 130840168 1 - 2.073 2.239 0.555
ENSG00000079819 E008 165.7578180 0.0009846238 1.700287e-08 2.008570e-07 6 130840169 130840181 13 - 2.125 2.315 0.634
ENSG00000079819 E009 162.3365081 0.0002935529 2.839823e-06 2.137025e-05 6 130840182 130840187 6 - 2.140 2.288 0.495
ENSG00000079819 E010 335.6148877 0.0001960111 5.584975e-28 7.907749e-26 6 130840188 130840372 185 - 2.403 2.638 0.783
ENSG00000079819 E011 106.4788675 0.0003050663 3.607072e-17 1.636636e-15 6 130840373 130840375 3 - 1.861 2.171 1.040
ENSG00000079819 E012 365.6585471 0.0001289857 7.798181e-21 5.522774e-19 6 130840376 130840594 219 - 2.466 2.657 0.637
ENSG00000079819 E013 134.9796633 0.0002701711 1.646481e-05 1.041090e-04 6 130840595 130840598 4 - 2.059 2.207 0.496
ENSG00000079819 E014 128.7404390 0.0002732273 9.429027e-04 3.764279e-03 6 130858131 130858135 5 - 2.053 2.172 0.400
ENSG00000079819 E015 267.9687837 0.0002028910 2.022883e-02 5.196398e-02 6 130858136 130858224 89 - 2.398 2.465 0.222
ENSG00000079819 E016 175.8525800 0.0003153557 8.529868e-01 9.089292e-01 6 130858225 130858243 19 - 2.245 2.255 0.034
ENSG00000079819 E017 2.1527721 0.0166955762 6.330012e-01 7.477859e-01 6 130858244 130858328 85 - 0.538 0.468 -0.339
ENSG00000079819 E018 293.9442239 0.0001644896 4.637580e-01 6.035251e-01 6 130863638 130863718 81 - 2.471 2.471 -0.001
ENSG00000079819 E019 330.1487718 0.0001443471 9.458191e-01 9.699964e-01 6 130865536 130865634 99 - 2.512 2.529 0.055
ENSG00000079819 E020 1.2146496 0.0100506421 7.932305e-01 8.677981e-01 6 130865635 130865833 199 - 0.373 0.335 -0.225
ENSG00000079819 E021 314.0124278 0.0001665033 9.148057e-01 9.500553e-01 6 130867459 130867581 123 - 2.489 2.506 0.057
ENSG00000079819 E022 6.4332440 0.0315435408 9.399817e-01 9.663201e-01 6 130867582 130868907 1326 - 0.861 0.861 -0.001
ENSG00000079819 E023 249.6645331 0.0001708921 2.140661e-01 3.433286e-01 6 130869563 130869658 96 - 2.379 2.422 0.145
ENSG00000079819 E024 262.6945059 0.0002531049 2.177789e-01 3.477278e-01 6 130869659 130869811 153 - 2.402 2.445 0.144
ENSG00000079819 E025 153.7990185 0.0041088463 1.197453e-01 2.196133e-01 6 130869812 130869851 40 - 2.151 2.233 0.275
ENSG00000079819 E026 233.6059127 0.0046004264 7.524018e-01 8.385966e-01 6 130869852 130869944 93 - 2.368 2.374 0.020
ENSG00000079819 E027 201.8408580 0.0001958301 2.439065e-01 3.787798e-01 6 130869945 130870038 94 - 2.315 2.301 -0.048
ENSG00000079819 E028 165.7955432 0.0001980684 2.187915e-02 5.542622e-02 6 130870039 130870076 38 - 2.245 2.196 -0.164
ENSG00000079819 E029 175.3151476 0.0010606204 4.370719e-02 9.784921e-02 6 130870077 130870126 50 - 2.267 2.219 -0.161
ENSG00000079819 E030 5.3144744 0.0037026901 8.429138e-01 9.021383e-01 6 130870328 130870381 54 - 0.771 0.809 0.152
ENSG00000079819 E031 3.2997597 0.0110854535 7.987411e-05 4.272379e-04 6 130872371 130872538 168 - 0.827 0.143 -3.879
ENSG00000079819 E032 10.6809830 0.0056163590 1.070738e-04 5.546463e-04 6 130876674 130876775 102 - 1.211 0.782 -1.592
ENSG00000079819 E033 162.1469310 0.0002079882 8.636609e-04 3.486351e-03 6 130878104 130878250 147 - 2.247 2.167 -0.267
ENSG00000079819 E034 6.0691531 0.0817039205 1.309720e-03 5.009743e-03 6 130878251 130878625 375 - 1.034 0.408 -2.654
ENSG00000079819 E035 92.5907860 0.0004597184 1.513015e-02 4.078074e-02 6 130880144 130880206 63 - 2.003 1.925 -0.261
ENSG00000079819 E036 4.9318402 0.0056163496 4.959875e-02 1.084488e-01 6 130880454 130880489 36 - 0.877 0.614 -1.072
ENSG00000079819 E037 12.7045338 0.0480105269 2.825648e-04 1.308732e-03 6 130880601 130881581 981 - 1.304 0.757 -2.022
ENSG00000079819 E038 19.6968837 0.0219614189 6.035031e-11 1.102738e-09 6 130881582 130883167 1586 - 1.524 0.723 -2.919
ENSG00000079819 E039 243.0883239 0.0002792608 2.509791e-05 1.521122e-04 6 130885096 130885268 173 - 2.424 2.338 -0.287
ENSG00000079819 E040 228.8635829 0.0009041106 2.015986e-06 1.567118e-05 6 130890294 130890466 173 - 2.409 2.292 -0.390
ENSG00000079819 E041 156.6409875 0.0002194613 4.079188e-04 1.804770e-03 6 130894344 130894441 98 - 2.234 2.147 -0.293
ENSG00000079819 E042 234.7971826 0.0018900630 2.313966e-04 1.097416e-03 6 130894967 130895119 153 - 2.414 2.312 -0.340
ENSG00000079819 E043 104.5599474 0.0072814039 1.154579e-02 3.245611e-02 6 130899491 130899493 3 - 2.074 1.949 -0.419
ENSG00000079819 E044 177.4606193 0.0050515168 4.860996e-03 1.554526e-02 6 130899494 130899552 59 - 2.296 2.185 -0.373
ENSG00000079819 E045 130.8807785 0.0047032392 2.462903e-03 8.652564e-03 6 130899553 130899574 22 - 2.170 2.043 -0.423
ENSG00000079819 E046 116.5678485 0.0016012675 2.275524e-05 1.392187e-04 6 130899575 130899578 4 - 2.129 1.979 -0.502
ENSG00000079819 E047 305.0717572 0.0032384860 8.496426e-05 4.515070e-04 6 130900962 130901180 219 - 2.535 2.414 -0.402
ENSG00000079819 E048 186.4324011 0.0044938945 1.083423e-04 5.604741e-04 6 130904465 130904540 76 - 2.333 2.188 -0.485
ENSG00000079819 E049 161.5454408 0.0104355889 3.226780e-03 1.093489e-02 6 130908821 130908863 43 - 2.273 2.124 -0.499
ENSG00000079819 E050 210.1132325 0.0049353113 2.334813e-03 8.259234e-03 6 130926605 130926709 105 - 2.372 2.260 -0.375
ENSG00000079819 E051 260.9799963 0.0002041897 1.067648e-10 1.875298e-09 6 130955105 130955272 168 - 2.474 2.341 -0.444
ENSG00000079819 E052 145.9232345 0.0002428786 1.139785e-11 2.350630e-10 6 130955273 130955317 45 - 2.243 2.050 -0.646
ENSG00000079819 E053 105.0019047 0.0002712075 7.330663e-08 7.641953e-07 6 130955994 130955997 4 - 2.097 1.919 -0.595
ENSG00000079819 E054 127.5957134 0.0002477113 1.824312e-08 2.142921e-07 6 130955998 130956024 27 - 2.177 2.009 -0.562
ENSG00000079819 E055 194.8091197 0.0016650158 2.963683e-07 2.745530e-06 6 130956025 130956103 79 - 2.353 2.200 -0.510
ENSG00000079819 E056 145.7112044 0.0006857582 2.212660e-06 1.704476e-05 6 130956104 130956131 28 - 2.224 2.087 -0.457
ENSG00000079819 E057 362.4873124 0.0016217042 2.050622e-13 5.576862e-12 6 130956132 130956499 368 - 2.634 2.451 -0.612
ENSG00000079819 E058 0.0000000       6 130970283 130970483 201 -      
ENSG00000079819 E059 0.1472490 0.0438353064 6.583784e-01   6 130978605 130978796 192 - 0.105 0.000 -10.925
ENSG00000079819 E060 0.0000000       6 131000620 131000767 148 -      
ENSG00000079819 E061 0.0000000       6 131013562 131013595 34 -      
ENSG00000079819 E062 0.0000000       6 131014103 131014191 89 -      
ENSG00000079819 E063 0.1472490 0.0438353064 6.583784e-01   6 131015281 131015333 53 - 0.105 0.000 -10.925
ENSG00000079819 E064 0.1472490 0.0438353064 6.583784e-01   6 131015819 131015842 24 - 0.105 0.000 -10.925
ENSG00000079819 E065 0.1482932 0.0415730021 3.595710e-01   6 131062380 131062576 197 - 0.000 0.142 11.673
ENSG00000079819 E066 18.5694427 0.0009881044 7.426428e-01 8.314951e-01 6 131063142 131063154 13 - 1.297 1.285 -0.041
ENSG00000079819 E067 86.5674880 0.0052697309 4.139925e-04 1.828111e-03 6 131063155 131063322 168 - 2.012 1.839 -0.580