ENSG00000079805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359692 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding protein_coding 101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 46.171340 76.073240 29.083984 7.9784144 1.060841 -1.3868578 0.43927083 0.4787667 0.42460000 -0.05416667 4.404364e-01 1.286974e-23 FALSE TRUE
ENST00000408974 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding protein_coding 101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 13.817182 22.371958 11.137339 1.7228189 1.771310 -1.0056369 0.14792917 0.1433667 0.16293333 0.01956667 8.608082e-01 1.286974e-23 FALSE TRUE
ENST00000585892 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding protein_coding 101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 12.164715 23.294125 5.490878 1.0484200 1.003533 -2.0828515 0.10765833 0.1476333 0.08046667 -0.06716667 2.382216e-02 1.286974e-23 FALSE TRUE
ENST00000591818 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding protein_coding 101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 2.364432 7.882638 0.000000 0.8684195 0.000000 -9.6243638 0.01566250 0.0509000 0.00000000 -0.05090000 1.286974e-23 1.286974e-23 FALSE FALSE
MSTRG.16425.10 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding   101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 1.541289 0.000000 3.574161 0.0000000 1.895968 8.4854918 0.02195417 0.0000000 0.05173333 0.05173333 1.202372e-01 1.286974e-23 FALSE TRUE
MSTRG.16425.3 ENSG00000079805 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM2 protein_coding   101.0475 157.9901 68.48812 8.824976 0.5870472 -1.205789 14.099839 18.150120 11.617052 1.3065285 0.323863 -0.6432883 0.14961667 0.1147000 0.16956667 0.05486667 5.440926e-07 1.286974e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079805 E001 1.0621005 0.0140079857 4.866372e-01 6.243529e-01 19 10717958 10717991 34 + 0.176 0.314 1.091
ENSG00000079805 E002 1.8725669 0.0474831363 9.095880e-01 9.465474e-01 19 10717992 10718000 9 + 0.397 0.431 0.184
ENSG00000079805 E003 5.7425169 0.0028945994 6.789623e-04 2.822137e-03 19 10718001 10718054 54 + 1.040 0.622 -1.646
ENSG00000079805 E004 11.4537902 0.0017736416 1.054253e-09 1.556704e-08 19 10718055 10718078 24 + 1.379 0.800 -2.111
ENSG00000079805 E005 15.8645645 0.0091078000 2.400003e-13 6.467615e-12 19 10718079 10718091 13 + 1.549 0.869 -2.426
ENSG00000079805 E006 17.4897280 0.0035539404 2.758103e-18 1.437453e-16 19 10718092 10718092 1 + 1.606 0.880 -2.579
ENSG00000079805 E007 170.7027294 0.0370908312 1.352288e-03 5.150520e-03 19 10718093 10718207 115 + 2.362 2.087 -0.918
ENSG00000079805 E008 477.2923836 0.0125633361 1.044208e-02 2.984328e-02 19 10718208 10718403 196 + 2.706 2.589 -0.390
ENSG00000079805 E009 0.3299976 0.0274424043 5.719565e-01   19 10718561 10718646 86 + 0.000 0.154 9.497
ENSG00000079805 E010 0.0000000       19 10755121 10755488 368 +      
ENSG00000079805 E011 1.0391862 0.4193752464 4.490832e-01 5.902910e-01 19 10759634 10759737 104 + 0.398 0.255 -0.910
ENSG00000079805 E012 424.4862683 0.0042423467 2.258279e-02 5.688470e-02 19 10759738 10759811 74 + 2.615 2.554 -0.204
ENSG00000079805 E013 0.0000000       19 10763099 10763616 518 +      
ENSG00000079805 E014 0.0000000       19 10768553 10768862 310 +      
ENSG00000079805 E015 0.0000000       19 10769289 10769446 158 +      
ENSG00000079805 E016 790.1608200 0.0018553120 5.908325e-10 9.143979e-09 19 10772479 10772628 150 + 2.934 2.802 -0.437
ENSG00000079805 E017 1080.8894122 0.0004438521 7.374961e-28 1.032642e-25 19 10775703 10775906 204 + 3.077 2.933 -0.481
ENSG00000079805 E018 564.1325600 0.0004232846 6.275097e-15 2.131227e-13 19 10777118 10777168 51 + 2.783 2.656 -0.422
ENSG00000079805 E019 611.4462273 0.0008901187 1.519794e-07 1.490580e-06 19 10777169 10777216 48 + 2.793 2.702 -0.303
ENSG00000079805 E020 0.4031496 0.0245318877 5.695232e-01 6.960753e-01 19 10781374 10781567 194 + 0.000 0.154 9.502
ENSG00000079805 E021 0.0000000       19 10781568 10781795 228 +      
ENSG00000079805 E022 629.3447221 0.0004965419 2.552962e-09 3.509804e-08 19 10782960 10783015 56 + 2.806 2.714 -0.305
ENSG00000079805 E023 746.4930288 0.0011032667 9.534167e-07 7.942917e-06 19 10783016 10783120 105 + 2.875 2.791 -0.278
ENSG00000079805 E024 0.8783198 0.0133878929 6.497424e-01 7.608946e-01 19 10786430 10786563 134 + 0.176 0.267 0.769
ENSG00000079805 E025 879.4390813 0.0010164576 3.372625e-04 1.529391e-03 19 10786564 10786706 143 + 2.923 2.872 -0.171
ENSG00000079805 E026 1.0394002 0.3704886690 5.107267e-01 6.459075e-01 19 10786707 10786741 35 + 0.399 0.219 -1.203
ENSG00000079805 E027 850.2849407 0.0013160036 1.097988e-02 3.111369e-02 19 10793720 10793855 136 + 2.898 2.862 -0.117
ENSG00000079805 E028 1.6134561 0.1395694087 2.249236e-01 3.563337e-01 19 10793856 10794734 879 + 0.176 0.457 1.904
ENSG00000079805 E029 704.0234025 0.0001201944 3.031823e-07 2.802898e-06 19 10795372 10795439 68 + 2.831 2.770 -0.204
ENSG00000079805 E030 31.7885121 0.0385948992 4.264640e-02 9.590024e-02 19 10795440 10795715 276 + 1.607 1.390 -0.744
ENSG00000079805 E031 40.1625828 0.0006329001 1.406191e-04 7.061406e-04 19 10795716 10796060 345 + 1.694 1.488 -0.702
ENSG00000079805 E032 610.6882176 0.0007959944 7.929380e-01 8.675950e-01 19 10796061 10796199 139 + 2.707 2.732 0.082
ENSG00000079805 E033 242.8128400 0.0008094509 1.441676e-43 6.151377e-41 19 10797380 10797518 139 + 2.559 2.208 -1.172
ENSG00000079805 E034 4.8746027 0.0034228754 1.786289e-02 4.684290e-02 19 10798387 10798485 99 + 0.929 0.622 -1.233
ENSG00000079805 E035 793.1952256 0.0009027033 2.303243e-05 1.407738e-04 19 10798486 10798572 87 + 2.888 2.823 -0.214
ENSG00000079805 E036 834.8722395 0.0001100309 1.369854e-03 5.208390e-03 19 10802288 10802358 71 + 2.883 2.854 -0.094
ENSG00000079805 E037 30.5539739 0.0045773705 1.176029e-08 1.431362e-07 19 10802359 10803638 1280 + 1.689 1.304 -1.322
ENSG00000079805 E038 4.5620821 0.0292269493 2.856593e-02 6.914181e-02 19 10803639 10803668 30 + 0.902 0.578 -1.327
ENSG00000079805 E039 27.1962600 0.0008309894 7.414211e-10 1.127197e-08 19 10803669 10804912 1244 + 1.647 1.250 -1.371
ENSG00000079805 E040 34.6666321 0.0008757045 1.778308e-06 1.398660e-05 19 10804980 10805915 936 + 1.685 1.409 -0.945
ENSG00000079805 E041 770.8219037 0.0004516231 2.482445e-01 3.838583e-01 19 10805916 10805967 52 + 2.831 2.829 -0.006
ENSG00000079805 E042 11.1726187 0.0015319155 5.753979e-01 7.010077e-01 19 10808519 10808568 50 + 1.060 1.015 -0.165
ENSG00000079805 E043 149.0912518 0.0002288569 1.784763e-02 4.680676e-02 19 10808569 10808580 12 + 2.042 2.139 0.325
ENSG00000079805 E044 22.4374910 0.0009610636 3.308281e-01 4.743928e-01 19 10808581 10809207 627 + 1.351 1.290 -0.214
ENSG00000079805 E045 143.4854882 0.0034428291 9.817455e-01 9.926335e-01 19 10809208 10812263 3056 + 2.082 2.103 0.070
ENSG00000079805 E046 1002.1197282 0.0005480091 5.150429e-01 6.497583e-01 19 10812264 10812377 114 + 2.938 2.946 0.026
ENSG00000079805 E047 1111.6500949 0.0003707729 6.179870e-02 1.296535e-01 19 10819980 10820089 110 + 2.953 2.999 0.153
ENSG00000079805 E048 3.1497700 0.0675217110 5.731826e-01 6.991676e-01 19 10823224 10823787 564 + 0.476 0.601 0.586
ENSG00000079805 E049 1205.2976840 0.0002303588 2.034062e-02 5.219807e-02 19 10823788 10823899 112 + 2.986 3.035 0.162
ENSG00000079805 E050 4.7469138 0.0094920802 3.619258e-02 8.395260e-02 19 10823900 10824806 907 + 0.397 0.771 1.711
ENSG00000079805 E051 1443.6931096 0.0014448089 8.305126e-02 1.643289e-01 19 10825057 10825221 165 + 3.060 3.116 0.186
ENSG00000079805 E052 910.0575255 0.0018609275 3.843743e-02 8.817005e-02 19 10829036 10829111 76 + 2.848 2.919 0.238
ENSG00000079805 E053 1126.7082488 0.0026744532 6.649555e-06 4.603297e-05 19 10829112 10829268 157 + 2.883 3.028 0.482
ENSG00000079805 E054 1159.0740789 0.0023066090 1.047531e-13 2.967722e-12 19 10830127 10830337 211 + 2.837 3.053 0.720
ENSG00000079805 E055 582.5286994 0.0003750625 2.060885e-18 1.092108e-16 19 10830338 10830378 41 + 2.555 2.747 0.641
ENSG00000079805 E056 6.8600494 0.0024433498 4.743888e-02 1.046150e-01 19 10830379 10830534 156 + 0.999 0.770 -0.878
ENSG00000079805 E057 299.8196759 0.0005478998 9.863287e-16 3.725220e-14 19 10830978 10830980 3 + 2.227 2.466 0.800
ENSG00000079805 E058 2587.0570467 0.0012269346 1.058096e-50 6.726615e-48 19 10830981 10831903 923 + 3.122 3.415 0.975
ENSG00000079805 E059 452.9464755 0.0003582397 2.815985e-03 9.721375e-03 19 10832304 10832991 688 + 2.537 2.617 0.267
ENSG00000079805 E060 303.2964175 0.0014573871 3.286526e-08 3.671989e-07 19 10832992 10833488 497 + 2.279 2.468 0.630