ENSG00000079691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329474 ENSG00000079691 HEK293_OSMI2_2hA HEK293_TMG_2hB CARMIL1 protein_coding protein_coding 1.771188 1.629359 2.403129 0.1291591 0.1458286 0.5577732 1.57935962 0.9341270 2.30962364 0.03409923 0.11708198 1.296838 0.88543750 0.5820667 0.9622 0.3801333 3.394127e-08 3.394127e-08 FALSE TRUE
ENST00000476458 ENSG00000079691 HEK293_OSMI2_2hA HEK293_TMG_2hB CARMIL1 protein_coding processed_transcript 1.771188 1.629359 2.403129 0.1291591 0.1458286 0.5577732 0.12519274 0.4447874 0.00000000 0.23090325 0.00000000 -5.507120 0.07808750 0.2571667 0.0000 -0.2571667 1.309118e-01 3.394127e-08 FALSE FALSE
ENST00000635618 ENSG00000079691 HEK293_OSMI2_2hA HEK293_TMG_2hB CARMIL1 protein_coding nonsense_mediated_decay 1.771188 1.629359 2.403129 0.1291591 0.1458286 0.5577732 0.05028612 0.2200911 0.04933939 0.12555046 0.04933939 -1.955143 0.02820417 0.1398667 0.0184 -0.1214667 4.688002e-01 3.394127e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079691 E001 0.2955422 0.0290448326 6.560639e-01   6 25279078 25279239 162 + 0.093 0.159 0.879
ENSG00000079691 E002 12.0952203 0.0042113909 6.435537e-03 1.975490e-02 6 25279374 25279835 462 + 1.200 0.907 -1.072
ENSG00000079691 E003 11.3804914 0.0144210452 5.479843e-02 1.176496e-01 6 25284812 25284909 98 + 1.159 0.931 -0.835
ENSG00000079691 E004 9.6466022 0.0031165222 5.673692e-02 1.210078e-01 6 25420114 25420164 51 + 1.097 0.882 -0.797
ENSG00000079691 E005 10.0271387 0.0020831689 2.278709e-02 5.730333e-02 6 25426501 25426560 60 + 1.114 0.857 -0.954
ENSG00000079691 E006 12.2046809 0.0124274598 1.209729e-03 4.673700e-03 6 25435483 25435604 122 + 1.232 0.855 -1.382
ENSG00000079691 E007 9.0386086 0.0076325063 3.103921e-03 1.057168e-02 6 25449898 25449995 98 + 1.106 0.734 -1.412
ENSG00000079691 E008 9.6898485 0.0665379811 4.032420e-02 9.162688e-02 6 25450339 25450409 71 + 1.131 0.767 -1.367
ENSG00000079691 E009 9.2903288 0.0033230418 3.244266e-02 7.670720e-02 6 25450638 25450711 74 + 1.080 0.829 -0.941
ENSG00000079691 E010 0.0000000       6 25452044 25452597 554 +      
ENSG00000079691 E011 0.0000000       6 25465536 25465872 337 +      
ENSG00000079691 E012 9.7765727 0.0018080762 1.717046e-01 2.904390e-01 6 25465873 25465948 76 + 1.080 0.930 -0.555
ENSG00000079691 E013 9.2600602 0.0477122628 8.815519e-01 9.281023e-01 6 25471169 25471257 89 + 1.024 0.988 -0.133
ENSG00000079691 E014 10.0693436 0.0198831239 5.379586e-01 6.694341e-01 6 25472427 25472521 95 + 1.071 0.991 -0.292
ENSG00000079691 E015 0.2998086 0.0285831046 6.550809e-01   6 25472522 25472631 110 + 0.093 0.159 0.879
ENSG00000079691 E016 8.7715246 0.0019149296 6.437619e-01 7.562234e-01 6 25482257 25482343 87 + 1.005 0.952 -0.197
ENSG00000079691 E017 10.6613370 0.0016572146 2.126276e-01 3.416450e-01 6 25488482 25488585 104 + 1.105 0.973 -0.485
ENSG00000079691 E018 10.6528093 0.0016546911 2.427979e-03 8.546354e-03 6 25491732 25491809 78 + 1.166 0.829 -1.251
ENSG00000079691 E019 11.0300389 0.0018731125 1.393951e-04 7.009604e-04 6 25491948 25492024 77 + 1.200 0.768 -1.614
ENSG00000079691 E020 7.0086690 0.0024514990 5.064126e-02 1.102980e-01 6 25495111 25495120 10 + 0.984 0.734 -0.967
ENSG00000079691 E021 11.1512465 0.0015464683 1.812834e-02 4.740514e-02 6 25495121 25495215 95 + 1.159 0.907 -0.926
ENSG00000079691 E022 8.7594199 0.0171206637 2.779508e-01 4.175930e-01 6 25500166 25500235 70 + 1.025 0.884 -0.528
ENSG00000079691 E023 0.1451727 0.0423118930 8.972279e-01   6 25507479 25507490 12 + 0.093 0.000 -10.456
ENSG00000079691 E024 11.7424803 0.0044917607 4.374753e-01 5.794395e-01 6 25509656 25509737 82 + 1.129 1.047 -0.296
ENSG00000079691 E025 13.0387620 0.0014584691 3.809466e-01 5.252260e-01 6 25510507 25510606 100 + 1.166 1.081 -0.307
ENSG00000079691 E026 11.0982635 0.0026114845 3.744007e-01 5.188212e-01 6 25510708 25510762 55 + 1.106 1.012 -0.341
ENSG00000079691 E027 17.7293961 0.0010908866 8.935121e-01 9.359090e-01 6 25515675 25515847 173 + 1.262 1.271 0.033
ENSG00000079691 E028 10.2987674 0.0016518806 9.614505e-01 9.797297e-01 6 25517347 25517415 69 + 1.044 1.048 0.012
ENSG00000079691 E029 13.0269131 0.0014340098 1.722938e-01 2.911968e-01 6 25520244 25520337 94 + 1.080 1.205 0.446
ENSG00000079691 E030 12.3583085 0.0014237906 8.461923e-02 1.667898e-01 6 25528795 25528893 99 + 1.044 1.205 0.577
ENSG00000079691 E031 11.9190173 0.0048550119 1.283183e-01 2.318041e-01 6 25537855 25537983 129 + 1.044 1.192 0.532
ENSG00000079691 E032 12.3620876 0.0017815208 8.803504e-01 9.272598e-01 6 25539947 25540078 132 + 1.113 1.126 0.045
ENSG00000079691 E033 16.1691124 0.0012565272 8.028685e-02 1.600087e-01 6 25550910 25551085 176 + 1.166 1.310 0.508
ENSG00000079691 E034 11.5799196 0.0015503007 6.306362e-02 1.318124e-01 6 25554009 25554096 88 + 1.015 1.192 0.640
ENSG00000079691 E035 14.3156492 0.0012507297 5.990796e-01 7.205546e-01 6 25556701 25556850 150 + 1.159 1.205 0.161
ENSG00000079691 E036 0.0000000       6 25576976 25576993 18 +      
ENSG00000079691 E037 9.1476918 0.0019234971 7.824270e-01 8.603028e-01 6 25580924 25580990 67 + 0.984 1.012 0.104
ENSG00000079691 E038 17.0190212 0.0170222647 5.989052e-01 7.204226e-01 6 25581243 25581439 197 + 1.226 1.280 0.191
ENSG00000079691 E039 15.6834370 0.0093027352 4.028229e-01 5.466159e-01 6 25594415 25594527 113 + 1.180 1.260 0.282
ENSG00000079691 E040 36.9668739 0.0007391960 1.001469e-01 1.907018e-01 6 25600314 25600746 433 + 1.533 1.624 0.312
ENSG00000079691 E041 10.4483511 0.0159209956 5.566306e-02 1.191210e-01 6 25604812 25604893 82 + 0.961 1.177 0.785
ENSG00000079691 E042 16.4780548 0.0233712131 2.002197e-01 3.265074e-01 6 25606061 25606273 213 + 1.179 1.309 0.457
ENSG00000079691 E043 10.3569291 0.0017050980 5.756103e-01 7.011763e-01 6 25610050 25610121 72 + 1.025 1.081 0.203
ENSG00000079691 E044 9.0452057 0.0019259527 4.170837e-01 5.604634e-01 6 25610122 25610181 60 + 0.962 1.047 0.317
ENSG00000079691 E045 0.0000000       6 25612377 25612401 25 +      
ENSG00000079691 E046 0.1817044 0.0404178031 2.653562e-01   6 25612737 25612739 3 + 0.000 0.159 10.655
ENSG00000079691 E047 1.2041528 0.1465964819 2.922689e-01 4.332204e-01 6 25612740 25612886 147 + 0.235 0.446 1.319
ENSG00000079691 E048 56.5525547 0.0005647386 5.970855e-14 1.752035e-12 6 25619447 25620530 1084 + 1.587 1.922 1.133