ENSG00000079459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220584 ENSG00000079459 HEK293_OSMI2_2hA HEK293_TMG_2hB FDFT1 protein_coding protein_coding 127.068 179.5988 74.77368 27.21706 0.4578151 -1.264062 86.92155 137.6877 42.27571 21.72479 2.463626 -1.70326250 0.6622542 0.7660 0.5654000 -0.2006000 0.01213193 0.01213193 FALSE TRUE
ENST00000529464 ENSG00000079459 HEK293_OSMI2_2hA HEK293_TMG_2hB FDFT1 protein_coding nonsense_mediated_decay 127.068 179.5988 74.77368 27.21706 0.4578151 -1.264062 17.97064 14.3231 14.79610 10.56154 1.747730 0.04684138 0.1550833 0.0747 0.1980333 0.1233333 0.61407559 0.01213193 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079459 E001 2.8209198 3.672174e-02 1.952054e-01 3.202462e-01 8 11795573 11795580 8 + 0.685 0.467 -0.993
ENSG00000079459 E002 37.3969262 1.041287e-03 1.639159e-12 3.876154e-11 8 11795581 11795687 107 + 1.788 1.389 -1.363
ENSG00000079459 E003 107.8796495 3.422789e-03 5.750660e-21 4.134517e-19 8 11795688 11796011 324 + 2.239 1.832 -1.364
ENSG00000079459 E004 0.4460135 3.069588e-02 8.565427e-03 2.520377e-02 8 11798456 11798491 36 + 0.423 0.000 -13.922
ENSG00000079459 E005 0.3289534 2.987684e-02 4.291286e-01   8 11802239 11802257 19 + 0.190 0.077 -1.510
ENSG00000079459 E006 9.4187350 1.547927e-02 1.155213e-01 2.135986e-01 8 11802258 11802455 198 + 1.079 0.891 -0.696
ENSG00000079459 E007 0.2944980 3.780182e-01 8.003182e-02   8 11802611 11802642 32 + 0.322 0.000 -12.528
ENSG00000079459 E008 14.3680733 1.267958e-03 9.283603e-02 1.795615e-01 8 11802643 11802738 96 + 1.229 1.085 -0.511
ENSG00000079459 E009 14.0391199 1.418577e-03 1.137142e-01 2.109393e-01 8 11802739 11802740 2 + 1.214 1.078 -0.486
ENSG00000079459 E010 15.4385944 1.229814e-03 5.808402e-02 1.233477e-01 8 11802741 11802745 5 + 1.269 1.112 -0.557
ENSG00000079459 E011 39.9066782 6.588130e-04 1.715336e-08 2.024831e-07 8 11802746 11802758 13 + 1.760 1.453 -1.048
ENSG00000079459 E012 100.0055663 2.996473e-04 4.428839e-16 1.750532e-14 8 11802759 11802765 7 + 2.136 1.850 -0.960
ENSG00000079459 E013 124.9974791 2.740149e-04 1.128130e-09 1.656623e-08 8 11802766 11802767 2 + 2.169 1.977 -0.644
ENSG00000079459 E014 269.8911629 3.614961e-04 1.784946e-06 1.403531e-05 8 11802768 11802783 16 + 2.439 2.336 -0.345
ENSG00000079459 E015 704.3406192 6.117963e-04 8.526852e-04 3.447114e-03 8 11802784 11802910 127 + 2.813 2.764 -0.161
ENSG00000079459 E016 512.4494222 4.334240e-04 3.526764e-04 1.590759e-03 8 11802911 11802931 21 + 2.681 2.626 -0.185
ENSG00000079459 E017 3.8319537 1.601082e-01 1.834066e-01 3.054820e-01 8 11803012 11803088 77 + 0.847 0.523 -1.368
ENSG00000079459 E018 3.2419135 8.547344e-02 2.266064e-01 3.583522e-01 8 11803089 11803090 2 + 0.732 0.497 -1.035
ENSG00000079459 E019 4.3125363 5.086658e-03 8.008416e-03 2.379875e-02 8 11803091 11803094 4 + 0.911 0.545 -1.510
ENSG00000079459 E020 7.3212877 9.259199e-03 3.311324e-02 7.803561e-02 8 11803095 11803225 131 + 1.037 0.779 -0.979
ENSG00000079459 E021 6.1411821 3.253511e-02 1.438666e-01 2.532765e-01 8 11803226 11803304 79 + 0.939 0.722 -0.847
ENSG00000079459 E022 4.6373344 3.345993e-02 2.552951e-01 3.921489e-01 8 11803305 11803321 17 + 0.812 0.633 -0.736
ENSG00000079459 E023 21.2018340 3.609560e-02 5.925910e-01 7.151202e-01 8 11803322 11803518 197 + 1.215 1.283 0.239
ENSG00000079459 E024 19.9724421 9.310908e-04 5.699985e-01 6.965035e-01 8 11803519 11803832 314 + 1.200 1.268 0.242
ENSG00000079459 E025 10.1015039 7.812129e-02 1.319374e-03 5.041850e-03 8 11807943 11808317 375 + 1.306 0.794 -1.881
ENSG00000079459 E026 8.7321784 8.524949e-02 1.296306e-01 2.336311e-01 8 11808417 11808489 73 + 1.118 0.834 -1.060
ENSG00000079459 E027 9.8683629 3.157494e-02 4.523958e-02 1.006276e-01 8 11808490 11808509 20 + 1.152 0.890 -0.967
ENSG00000079459 E028 30.8807947 2.240490e-02 5.131147e-03 1.628521e-02 8 11808510 11808790 281 + 1.620 1.351 -0.927
ENSG00000079459 E029 15.1634574 2.005146e-03 1.228383e-03 4.737075e-03 8 11808791 11808793 3 + 1.340 1.064 -0.979
ENSG00000079459 E030 824.4619503 3.921632e-04 1.923532e-05 1.197960e-04 8 11808794 11808891 98 + 2.887 2.831 -0.185
ENSG00000079459 E031 0.1472490 4.446621e-02 1.600609e-01   8 11809144 11809255 112 + 0.190 0.000 -12.190
ENSG00000079459 E032 0.3686942 4.949971e-02 4.387823e-01 5.806306e-01 8 11809256 11809490 235 + 0.190 0.077 -1.505
ENSG00000079459 E033 0.9609220 2.858246e-01 2.430273e-01 3.777458e-01 8 11809491 11809666 176 + 0.000 0.298 11.541
ENSG00000079459 E034 969.9447629 1.316574e-04 4.441576e-06 3.198917e-05 8 11809667 11809791 125 + 2.951 2.906 -0.150
ENSG00000079459 E035 845.1162089 1.071061e-03 1.838744e-03 6.722853e-03 8 11809792 11809850 59 + 2.892 2.841 -0.169
ENSG00000079459 E036 0.0000000       8 11809851 11809976 126 +      
ENSG00000079459 E037 704.2727579 8.864787e-04 2.525430e-02 6.239454e-02 8 11821750 11821780 31 + 2.799 2.768 -0.105
ENSG00000079459 E038 1134.9252550 1.568746e-04 4.331714e-01 5.756102e-01 8 11821781 11821878 98 + 2.980 2.986 0.023
ENSG00000079459 E039 3.8531985 2.884798e-02 4.454130e-02 9.935494e-02 8 11826000 11826023 24 + 0.848 0.543 -1.279
ENSG00000079459 E040 959.4994981 1.366714e-04 2.963654e-01 4.375636e-01 8 11826024 11826078 55 + 2.887 2.918 0.105
ENSG00000079459 E041 1491.5040395 8.998542e-05 8.994969e-01 9.398801e-01 8 11826079 11826215 137 + 3.091 3.107 0.052
ENSG00000079459 E042 838.4191831 3.596186e-04 3.427340e-01 4.867567e-01 8 11830244 11830279 36 + 2.828 2.858 0.100
ENSG00000079459 E043 1254.0592374 9.252987e-05 5.160976e-04 2.219695e-03 8 11830280 11830420 141 + 2.981 3.041 0.198
ENSG00000079459 E044 1259.3281240 2.083676e-04 8.997935e-13 2.227112e-11 8 11831518 11831670 153 + 2.941 3.053 0.374
ENSG00000079459 E045 1.7221738 1.929764e-02 9.503111e-03 2.754534e-02 8 11831671 11831794 124 + 0.685 0.248 -2.318
ENSG00000079459 E046 1592.5955743 1.783289e-03 3.665483e-07 3.331645e-06 8 11838388 11838573 186 + 3.029 3.151 0.407
ENSG00000079459 E047 1584.4646021 2.290495e-03 8.365601e-08 8.626847e-07 8 11838574 11839304 731 + 3.009 3.152 0.475
ENSG00000079459 E048 1.6218621 1.182058e-02 2.352772e-01 3.686912e-01 8 11839308 11839312 5 + 0.190 0.436 1.655
ENSG00000079459 E049 10.0681036 4.201463e-03 3.309786e-02 7.800518e-02 8 11839313 11839521 209 + 0.732 1.034 1.159