ENSG00000079432

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000160740 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding protein_coding 20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 1.0521520 0.6304692 1.7674767 0.3766271 0.2115220 1.4726296 0.05504583 0.02180000 0.12310000 0.10130000 1.642517e-01 2.07186e-23 FALSE TRUE
ENST00000573349 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding protein_coding 20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 1.8329717 5.8184703 0.0000000 0.5077838 0.0000000 -9.1869735 0.06723750 0.20483333 0.00000000 -0.20483333 2.071860e-23 2.07186e-23 FALSE TRUE
ENST00000575354 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding protein_coding 20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 8.6273216 12.9406899 5.7226027 0.6672838 0.3258792 -1.1757668 0.41026667 0.44966667 0.40073333 -0.04893333 6.049217e-01 2.07186e-23 FALSE TRUE
ENST00000576505 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding protein_coding 20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 0.8252289 2.9573575 0.0000000 1.4788921 0.0000000 -8.2130349 0.03108750 0.10123333 0.00000000 -0.10123333 2.109381e-01 2.07186e-23 FALSE TRUE
ENST00000684265 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding processed_transcript 20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 2.5309364 1.4104067 2.4416194 0.2120963 0.4033432 0.7874309 0.14236250 0.04876667 0.17130000 0.12253333 1.654771e-04 2.07186e-23 FALSE TRUE
MSTRG.17219.21 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding   20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 1.3447347 0.2969144 1.9400113 0.2969144 0.9723370 2.6675741 0.06844583 0.01083333 0.13363333 0.12280000 3.874505e-01 2.07186e-23 FALSE TRUE
MSTRG.17219.22 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding   20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 1.2257867 1.5833489 0.0000000 0.7243696 0.0000000 -7.3159184 0.06205417 0.05203333 0.00000000 -0.05203333 7.494080e-06 2.07186e-23 FALSE TRUE
MSTRG.17219.6 ENSG00000079432 HEK293_OSMI2_2hA HEK293_TMG_2hB CIC protein_coding   20.59604 28.87833 14.31807 1.989602 0.279066 -1.011642 0.3245101 0.0000000 0.8040684 0.0000000 0.4328190 6.3470781 0.02151250 0.00000000 0.05713333 0.05713333 1.238175e-01 2.07186e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079432 E001 0.8115846 0.4491417503 8.122022e-01 8.808847e-01 19 42268483 42268536 54 + 0.154 0.255 0.909
ENSG00000079432 E002 0.8115846 0.4491417503 8.122022e-01 8.808847e-01 19 42268537 42268537 1 + 0.154 0.255 0.909
ENSG00000079432 E003 0.8115846 0.4491417503 8.122022e-01 8.808847e-01 19 42268538 42268538 1 + 0.154 0.255 0.909
ENSG00000079432 E004 0.9932890 0.1232136977 4.621893e-01 6.020502e-01 19 42268539 42268542 4 + 0.154 0.305 1.258
ENSG00000079432 E005 0.9932890 0.1232136977 4.621893e-01 6.020502e-01 19 42268543 42268543 1 + 0.154 0.305 1.258
ENSG00000079432 E006 4.0870361 0.0053313122 8.278864e-01 8.918137e-01 19 42268544 42268594 51 + 0.684 0.652 -0.138
ENSG00000079432 E007 0.2924217 0.0290785164 9.156191e-02   19 42269252 42269256 5 + 0.268 0.000 -11.511
ENSG00000079432 E008 1.9950262 0.0074637024 3.619385e-01 5.063438e-01 19 42269257 42269381 125 + 0.551 0.396 -0.778
ENSG00000079432 E009 123.8884427 0.0041340646 1.869630e-04 9.078218e-04 19 42271774 42274577 2804 + 2.167 2.005 -0.541
ENSG00000079432 E010 0.5911836 0.0244351979 2.027984e-01 3.297277e-01 19 42279992 42280203 212 + 0.000 0.242 10.216
ENSG00000079432 E011 7.4788820 0.1477433636 2.000252e-04 9.638602e-04 19 42284020 42284102 83 + 1.258 0.482 -3.072
ENSG00000079432 E012 7.6605864 0.1814532754 7.646987e-04 3.131306e-03 19 42284103 42284105 3 + 1.258 0.518 -2.897
ENSG00000079432 E013 10.1160117 0.2037720310 4.270177e-04 1.878273e-03 19 42284106 42284135 30 + 1.373 0.609 -2.883
ENSG00000079432 E014 11.7704417 0.1103683326 3.478521e-04 1.571581e-03 19 42284136 42284157 22 + 1.389 0.768 -2.272
ENSG00000079432 E015 12.3928610 0.0825864103 1.417670e-04 7.111325e-04 19 42284158 42284265 108 + 1.403 0.801 -2.190
ENSG00000079432 E016 5.2434169 0.0306905772 4.367861e-05 2.496037e-04 19 42284266 42284457 192 + 1.082 0.475 -2.481
ENSG00000079432 E017 1.0351233 0.0118602913 3.948575e-04 1.754781e-03 19 42284458 42284459 2 + 0.600 0.000 -13.566
ENSG00000079432 E018 2.1433961 0.0138231664 4.211297e-03 1.373440e-02 19 42284460 42284585 126 + 0.721 0.242 -2.511
ENSG00000079432 E019 4.3514470 0.0723455649 1.110477e-01 2.070797e-01 19 42284586 42284592 7 + 0.843 0.583 -1.080
ENSG00000079432 E020 13.0685612 0.1101939712 1.014269e-01 1.926376e-01 19 42284593 42284659 67 + 1.256 1.022 -0.840
ENSG00000079432 E021 12.8126711 0.1201429857 1.695830e-01 2.876546e-01 19 42284660 42284664 5 + 1.225 1.034 -0.687
ENSG00000079432 E022 38.4460827 0.0184202879 4.796490e-02 1.055746e-01 19 42284665 42284771 107 + 1.664 1.506 -0.541
ENSG00000079432 E023 93.7463245 0.0140513404 7.882929e-10 1.192143e-08 19 42284772 42286336 1565 + 2.181 1.761 -1.412
ENSG00000079432 E024 109.4878135 0.0092420466 5.856282e-03 1.823472e-02 19 42286771 42286920 150 + 2.108 1.956 -0.511
ENSG00000079432 E025 168.3811709 0.0060373789 1.093803e-05 7.201559e-05 19 42287006 42287240 235 + 2.320 2.124 -0.655
ENSG00000079432 E026 155.5443051 0.0117006559 6.027659e-04 2.543426e-03 19 42287320 42287449 130 + 2.282 2.092 -0.633
ENSG00000079432 E027 230.2071463 0.0040266962 3.346890e-06 2.480590e-05 19 42287545 42287727 183 + 2.439 2.269 -0.568
ENSG00000079432 E028 205.7942435 0.0007579232 2.743050e-09 3.752890e-08 19 42287810 42287975 166 + 2.387 2.222 -0.549
ENSG00000079432 E029 223.2676940 0.0001997951 1.231914e-10 2.142696e-09 19 42288888 42289090 203 + 2.415 2.257 -0.527
ENSG00000079432 E030 236.2370024 0.0002076612 1.460427e-08 1.746455e-07 19 42289181 42289406 226 + 2.426 2.290 -0.454
ENSG00000079432 E031 136.0589448 0.0015055057 2.901216e-02 7.003130e-02 19 42289848 42289951 104 + 2.150 2.073 -0.256
ENSG00000079432 E032 592.2034414 0.0010997350 8.618489e-02 1.692931e-01 19 42290233 42291466 1234 + 2.760 2.730 -0.102
ENSG00000079432 E033 137.3797144 0.0038024623 3.167514e-02 7.521352e-02 19 42291558 42291745 188 + 2.045 2.140 0.318
ENSG00000079432 E034 148.6822017 0.0009702124 6.855998e-01 7.883083e-01 19 42292086 42292207 122 + 2.133 2.146 0.047
ENSG00000079432 E035 166.2844431 0.0002355021 8.134792e-02 1.616624e-01 19 42292300 42292466 167 + 2.153 2.203 0.170
ENSG00000079432 E036 54.8219067 0.0004397261 2.987234e-01 4.401839e-01 19 42292566 42292568 3 + 1.676 1.728 0.175
ENSG00000079432 E037 237.6291601 0.0001772970 2.853405e-05 1.706018e-04 19 42292569 42292859 291 + 2.270 2.374 0.347
ENSG00000079432 E038 42.8272160 0.0059142967 4.303390e-02 9.660789e-02 19 42292956 42292958 3 + 1.512 1.652 0.477
ENSG00000079432 E039 243.4462991 0.0001724271 9.132433e-07 7.645553e-06 19 42292959 42293195 237 + 2.267 2.389 0.405
ENSG00000079432 E040 166.0291875 0.0007967926 4.175511e-04 1.841722e-03 19 42293196 42293281 86 + 2.107 2.222 0.383
ENSG00000079432 E041 105.3950904 0.0003244590 1.945527e-02 5.032198e-02 19 42293592 42293606 15 + 1.934 2.020 0.290
ENSG00000079432 E042 120.7993971 0.0005250024 9.964595e-03 2.867633e-02 19 42293607 42293656 50 + 1.986 2.078 0.308
ENSG00000079432 E043 139.9761977 0.0010457453 1.355074e-06 1.093986e-05 19 42293657 42293750 94 + 1.984 2.161 0.592
ENSG00000079432 E044 185.4990247 0.0012398491 6.698851e-05 3.655808e-04 19 42293751 42293836 86 + 2.141 2.273 0.443
ENSG00000079432 E045 63.7954157 0.0007482092 3.690171e-02 8.527430e-02 19 42293935 42293937 3 + 1.703 1.804 0.343
ENSG00000079432 E046 252.8433182 0.0018744085 2.587771e-03 9.028626e-03 19 42293938 42294089 152 + 2.300 2.399 0.331
ENSG00000079432 E047 263.2226135 0.0021518848 6.673744e-05 3.643261e-04 19 42294173 42294298 126 + 2.296 2.428 0.438
ENSG00000079432 E048 89.2597353 0.0003467044 4.280625e-02 9.619030e-02 19 42294299 42294304 6 + 1.864 1.945 0.273
ENSG00000079432 E049 4.2655964 0.0668042844 1.187019e-01 2.180832e-01 19 42294460 42294574 115 + 0.842 0.579 -1.091
ENSG00000079432 E050 2.7197292 0.0062354161 2.936993e-01 4.347450e-01 19 42294575 42294603 29 + 0.644 0.476 -0.777
ENSG00000079432 E051 246.8298103 0.0032845894 1.418531e-05 9.096761e-05 19 42294604 42294735 132 + 2.245 2.409 0.549
ENSG00000079432 E052 547.4421885 0.0135527180 4.681902e-06 3.354154e-05 19 42294824 42295797 974 + 2.518 2.780 0.873