ENSG00000079387

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448372 ENSG00000079387 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP1 protein_coding protein_coding 13.85614 7.791705 20.59999 0.6126024 0.402712 1.401483 2.102191 1.77831722 3.391459 0.26498050 0.3854320 0.9275509 0.16896250 0.22643333 0.1643000 -0.06213333 2.859475e-01 1.342315e-23 FALSE TRUE
ENST00000549518 ENSG00000079387 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP1 protein_coding protein_coding 13.85614 7.791705 20.59999 0.6126024 0.402712 1.401483 3.658832 4.64009692 3.314555 0.50775395 0.2140547 -0.4840995 0.34015833 0.59786667 0.1613667 -0.43650000 2.305862e-09 1.342315e-23 FALSE TRUE
MSTRG.7201.4 ENSG00000079387 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP1 protein_coding   13.85614 7.791705 20.59999 0.6126024 0.402712 1.401483 2.694440 0.64155405 4.188385 0.32776076 0.2143948 2.6878776 0.17441667 0.08366667 0.2038000 0.12013333 5.056835e-01 1.342315e-23 FALSE TRUE
MSTRG.7201.5 ENSG00000079387 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP1 protein_coding   13.85614 7.791705 20.59999 0.6126024 0.402712 1.401483 2.475326 0.05871076 4.499100 0.03613257 0.1206583 6.0361598 0.13978750 0.00690000 0.2187667 0.21186667 1.342315e-23 1.342315e-23 FALSE TRUE
MSTRG.7201.6 ENSG00000079387 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP1 protein_coding   13.85614 7.791705 20.59999 0.6126024 0.402712 1.401483 1.687387 0.21606190 3.082820 0.14135337 0.7904330 3.7741332 0.09695417 0.02573333 0.1483000 0.12256667 1.083870e-02 1.342315e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000079387 E001 3.0645162 0.0083446863 2.168749e-01 3.466379e-01 12 48042897 48042897 1 - 0.511 0.721 0.925
ENSG00000079387 E002 5.4238725 0.0029575619 4.171841e-01 5.605665e-01 12 48042898 48042973 76 - 0.756 0.882 0.492
ENSG00000079387 E003 203.6848831 0.0044658323 1.589603e-27 2.169636e-25 12 48042974 48043943 970 - 2.080 2.526 1.491
ENSG00000079387 E004 220.7177792 0.0031328751 4.779591e-21 3.465286e-19 12 48043944 48044502 559 - 2.174 2.516 1.140
ENSG00000079387 E005 182.0836802 0.0009289050 6.641214e-04 2.767433e-03 12 48044503 48044910 408 - 2.200 2.321 0.406
ENSG00000079387 E006 120.8215271 0.0017090187 1.305618e-01 2.349382e-01 12 48044911 48045146 236 - 2.043 2.122 0.264
ENSG00000079387 E007 127.6224836 0.0022332126 6.208701e-01 7.379230e-01 12 48045147 48045321 175 - 2.094 2.094 0.002
ENSG00000079387 E008 87.7704605 0.0003902911 8.339313e-01 8.960017e-01 12 48045322 48045384 63 - 1.928 1.942 0.047
ENSG00000079387 E009 99.7398128 0.0003926052 5.445426e-01 6.749935e-01 12 48046356 48046448 93 - 1.973 2.017 0.149
ENSG00000079387 E010 50.7364726 0.0004516772 5.186953e-01 6.529178e-01 12 48046449 48046451 3 - 1.677 1.732 0.185
ENSG00000079387 E011 94.4514555 0.0002837242 7.370868e-01 8.273573e-01 12 48046978 48047062 85 - 1.954 1.989 0.117
ENSG00000079387 E012 92.7669678 0.0029019338 9.138062e-01 9.494285e-01 12 48048001 48048080 80 - 1.950 1.978 0.095
ENSG00000079387 E013 128.1234682 0.0009964998 6.382526e-01 7.519218e-01 12 48048929 48049132 204 - 2.095 2.101 0.020
ENSG00000079387 E014 1.0276452 0.0197815211 1.012319e-01 1.923464e-01 12 48063631 48063709 79 - 0.161 0.461 2.079
ENSG00000079387 E015 88.1205725 0.0003056704 8.561899e-01 9.110826e-01 12 48063710 48063841 132 - 1.929 1.944 0.051
ENSG00000079387 E016 115.3844933 0.0020212659 6.484063e-03 1.988227e-02 12 48065065 48065220 156 - 2.080 1.991 -0.298
ENSG00000079387 E017 101.0647875 0.0017095470 6.492336e-03 1.990248e-02 12 48065596 48065680 85 - 2.026 1.937 -0.302
ENSG00000079387 E018 65.6413764 0.0029261298 3.103448e-02 7.398158e-02 12 48066927 48066965 39 - 1.839 1.747 -0.311
ENSG00000079387 E019 78.9306186 0.0037510226 2.369099e-02 5.917422e-02 12 48071667 48071721 55 - 1.921 1.826 -0.318
ENSG00000079387 E020 159.8857253 0.0033270396 4.905484e-04 2.124424e-03 12 48074324 48074607 284 - 2.232 2.114 -0.393
ENSG00000079387 E021 91.5417808 0.0008300549 2.010646e-05 1.246329e-04 12 48074690 48074793 104 - 2.003 1.848 -0.520
ENSG00000079387 E022 0.2998086 0.0291103371 6.120017e-01   12 48080084 48080092 9 - 0.088 0.168 1.075
ENSG00000079387 E023 2.0755677 0.0093549514 8.501270e-01 9.070399e-01 12 48080093 48080500 408 - 0.479 0.461 -0.092
ENSG00000079387 E024 85.3469883 0.0003104185 6.126671e-04 2.579459e-03 12 48083591 48083694 104 - 1.960 1.842 -0.397
ENSG00000079387 E025 73.2924523 0.0063482722 4.835501e-04 2.097136e-03 12 48083695 48083762 68 - 1.913 1.725 -0.633
ENSG00000079387 E026 0.0000000       12 48088553 48088800 248 -      
ENSG00000079387 E027 106.0394437 0.0076728034 1.560473e-04 7.740545e-04 12 48088801 48088960 160 - 2.073 1.878 -0.654
ENSG00000079387 E028 3.0520226 0.0599721996 2.808027e-01 4.206744e-01 12 48089163 48089293 131 - 0.661 0.461 -0.922
ENSG00000079387 E029 87.8074789 0.0003406046 3.138771e-11 6.022797e-10 12 48096343 48096427 85 - 2.010 1.751 -0.872
ENSG00000079387 E030 0.2966881 0.0270121331 4.736662e-01   12 48097737 48097993 257 - 0.161 0.000 -9.412
ENSG00000079387 E031 97.1787273 0.0003024140 6.167994e-07 5.358941e-06 12 48097994 48098124 131 - 2.032 1.860 -0.578
ENSG00000079387 E032 0.1451727 0.0431364276 1.000000e+00   12 48099062 48099154 93 - 0.088 0.000 -8.412
ENSG00000079387 E033 49.5145879 0.0042264365 6.668784e-04 2.777394e-03 12 48101469 48101516 48 - 1.746 1.551 -0.660
ENSG00000079387 E034 22.6647162 0.0008280228 1.069754e-02 3.044750e-02 12 48105402 48105456 55 - 1.413 1.233 -0.628
ENSG00000079387 E035 81.1622161 0.0020653575 1.556448e-03 5.818278e-03 12 48105457 48106027 571 - 1.940 1.812 -0.429
ENSG00000079387 E036 13.6141644 0.0012585723 1.669628e-04 8.221080e-04 12 48106028 48106079 52 - 1.256 0.882 -1.363