ENSG00000078902

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263646 ENSG00000078902 HEK293_OSMI2_2hA HEK293_TMG_2hB TOLLIP protein_coding protein_coding 37.1339 62.49759 25.51685 1.66673 1.213984 -1.292016 8.127232 13.46475 5.353754 0.412642 0.2594191 -1.3289434 0.2232958 0.2154667 0.2099333 -0.005533333 0.908911744 0.003241595 FALSE TRUE
ENST00000317204 ENSG00000078902 HEK293_OSMI2_2hA HEK293_TMG_2hB TOLLIP protein_coding protein_coding 37.1339 62.49759 25.51685 1.66673 1.213984 -1.292016 12.071578 19.99674 7.697983 1.710931 0.2749638 -1.3760607 0.3339375 0.3189667 0.3040333 -0.014933333 0.899641229 0.003241595 FALSE TRUE
ENST00000530541 ENSG00000078902 HEK293_OSMI2_2hA HEK293_TMG_2hB TOLLIP protein_coding protein_coding 37.1339 62.49759 25.51685 1.66673 1.213984 -1.292016 8.128675 12.81687 8.303929 1.214910 0.8020597 -0.6255667 0.2183250 0.2043667 0.3246000 0.120233333 0.003241595 0.003241595 FALSE FALSE
MSTRG.4938.6 ENSG00000078902 HEK293_OSMI2_2hA HEK293_TMG_2hB TOLLIP protein_coding   37.1339 62.49759 25.51685 1.66673 1.213984 -1.292016 6.730796 13.84080 2.830743 1.952070 0.4286203 -2.2856290 0.1682083 0.2234333 0.1100667 -0.113366667 0.046830847 0.003241595 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078902 E001 0.5514428 0.0197036277 0.4346817149 0.576985818 11 1274371 1274371 1 - 0.000 0.193 9.572
ENSG00000078902 E002 0.5514428 0.0197036277 0.4346817149 0.576985818 11 1274372 1274372 1 - 0.000 0.193 11.478
ENSG00000078902 E003 441.2511653 0.0002188768 0.4167234395 0.560106459 11 1274373 1275652 1280 - 2.543 2.559 0.054
ENSG00000078902 E004 724.6701170 0.0018531905 0.8237704171 0.888961996 11 1275653 1276816 1164 - 2.775 2.772 -0.012
ENSG00000078902 E005 473.8925075 0.0005849326 0.0349190602 0.081499460 11 1276817 1277012 196 - 2.552 2.598 0.154
ENSG00000078902 E006 397.6456769 0.0018552890 0.0427587577 0.096104099 11 1277013 1277154 142 - 2.467 2.526 0.199
ENSG00000078902 E007 383.1921755 0.0019386765 0.1965804266 0.321963967 11 1277155 1277253 99 - 2.467 2.506 0.132
ENSG00000078902 E008 0.5117019 0.0260727026 0.4365864691 0.578648413 11 1283283 1283597 315 - 0.000 0.193 11.379
ENSG00000078902 E009 387.3952447 0.0021665566 0.0775806860 0.155576276 11 1286002 1286092 91 - 2.460 2.514 0.181
ENSG00000078902 E010 212.1944800 0.0027976617 0.5800301505 0.704874317 11 1288624 1288635 12 - 2.227 2.249 0.073
ENSG00000078902 E011 497.8849330 0.0002753467 0.2672665893 0.405562481 11 1288636 1288776 141 - 2.627 2.606 -0.070
ENSG00000078902 E012 0.9921577 0.0126661727 0.6401689608 0.753457891 11 1290095 1290226 132 - 0.330 0.242 -0.607
ENSG00000078902 E013 465.9216610 0.0001822312 0.0168372079 0.044571128 11 1290227 1290409 183 - 2.616 2.570 -0.152
ENSG00000078902 E014 0.5244761 0.2604544103 0.1886344109 0.312019551 11 1290915 1291193 279 - 0.330 0.075 -2.586
ENSG00000078902 E015 0.7697675 0.0181673011 1.0000000000 1.000000000 11 1291826 1292170 345 - 0.195 0.193 -0.018
ENSG00000078902 E016 1.0297335 0.0121989077 0.1319673103 0.236848791 11 1295377 1295644 268 - 0.000 0.326 12.594
ENSG00000078902 E017 213.2028286 0.0003489334 0.2587321691 0.396041030 11 1295645 1295731 87 - 2.267 2.234 -0.111
ENSG00000078902 E018 114.8615558 0.0028321415 0.8138829829 0.882035190 11 1295732 1295738 7 - 1.982 1.971 -0.035
ENSG00000078902 E019 144.2723034 0.0060257554 0.2416408143 0.376116996 11 1295739 1295794 56 - 2.116 2.060 -0.187
ENSG00000078902 E020 1.0392854 0.0275618362 0.6465607707 0.758425138 11 1296456 1296608 153 - 0.195 0.286 0.714
ENSG00000078902 E021 11.2084754 0.0015493335 0.0183257643 0.047844125 11 1298149 1298564 416 - 0.744 1.052 1.175
ENSG00000078902 E022 0.4470576 0.0228610069 0.1290536633 0.232861518 11 1302584 1302790 207 - 0.330 0.074 -2.609
ENSG00000078902 E023 1.1415848 0.0123228224 0.0105360232 0.030056891 11 1305823 1306194 372 - 0.584 0.138 -2.927
ENSG00000078902 E024 103.7254345 0.0079799657 0.0370921901 0.085646426 11 1309466 1309486 21 - 2.018 1.902 -0.392
ENSG00000078902 E025 118.5338305 0.0087496722 0.0006133434 0.002582078 11 1309487 1309654 168 - 2.129 1.939 -0.636