ENSG00000078699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342704 ENSG00000078699 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFA2T2 protein_coding protein_coding 5.593804 5.312451 5.739103 0.2648911 0.2399383 0.1112461 2.3473477 1.91191257 3.0592695 0.95614193 0.06423097 0.6753526 0.41348333 0.343033333 0.53450000 0.19146667 7.563537e-01 9.627303e-05 FALSE TRUE
ENST00000359606 ENSG00000078699 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFA2T2 protein_coding protein_coding 5.593804 5.312451 5.739103 0.2648911 0.2399383 0.1112461 0.7454015 1.71153142 0.0000000 0.98081063 0.00000000 -7.4275487 0.14324583 0.341566667 0.00000000 -0.34156667 1.767799e-01 9.627303e-05 FALSE TRUE
ENST00000471007 ENSG00000078699 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFA2T2 protein_coding processed_transcript 5.593804 5.312451 5.739103 0.2648911 0.2399383 0.1112461 0.3880949 0.02815787 0.7392452 0.02815787 0.16970000 4.2953852 0.06400833 0.005866667 0.12786667 0.12200000 9.627303e-05 9.627303e-05 FALSE TRUE
ENST00000491618 ENSG00000078699 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFA2T2 protein_coding processed_transcript 5.593804 5.312451 5.739103 0.2648911 0.2399383 0.1112461 0.5731769 0.11188300 0.5522595 0.05595604 0.29032433 2.2057393 0.10059583 0.020066667 0.09293333 0.07286667 7.133695e-01 9.627303e-05 FALSE FALSE
MSTRG.20563.4 ENSG00000078699 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFA2T2 protein_coding   5.593804 5.312451 5.739103 0.2648911 0.2399383 0.1112461 0.9467293 0.93933740 1.0654381 0.57128296 0.06496842 0.1799316 0.17229583 0.175566667 0.18730000 0.01173333 8.561641e-01 9.627303e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078699 E001 0.1451727 0.0423717102 4.105289e-01   20 33490075 33490095 21 + 0.126 0.000 -9.154
ENSG00000078699 E002 1.3223456 0.1424445377 1.540789e-01 2.672147e-01 20 33490096 33490116 21 + 0.479 0.215 -1.649
ENSG00000078699 E003 1.7985481 0.0090809417 6.992512e-02 1.432501e-01 20 33490117 33490129 13 + 0.567 0.289 -1.507
ENSG00000078699 E004 14.7881097 0.0013034376 1.033114e-09 1.528468e-08 20 33490130 33490301 172 + 1.402 0.899 -1.804
ENSG00000078699 E005 0.0000000       20 33562334 33562364 31 +      
ENSG00000078699 E006 0.0000000       20 33562365 33562379 15 +      
ENSG00000078699 E007 0.2998086 0.0297104389 8.894653e-01   20 33562380 33562674 295 + 0.126 0.119 -0.097
ENSG00000078699 E008 1.5102910 0.0091933588 9.591370e-01 9.783901e-01 20 33573974 33574051 78 + 0.370 0.411 0.228
ENSG00000078699 E009 3.0529490 0.0051036299 6.951441e-01 7.958000e-01 20 33574052 33574261 210 + 0.605 0.584 -0.093
ENSG00000078699 E010 0.4782907 0.0222780911 1.170355e-01 2.157229e-01 20 33600336 33600465 130 + 0.000 0.288 11.617
ENSG00000078699 E011 0.1472490 0.0426087071 4.105386e-01   20 33601830 33601905 76 + 0.126 0.000 -10.806
ENSG00000078699 E012 30.4460705 0.0008698393 3.212557e-06 2.387920e-05 20 33606956 33607099 144 + 1.613 1.374 -0.820
ENSG00000078699 E013 52.7802598 0.0005025661 1.361735e-05 8.767715e-05 20 33611094 33611335 242 + 1.803 1.648 -0.525
ENSG00000078699 E014 1.4059059 0.0096608038 2.025804e-01 3.294356e-01 20 33618448 33618546 99 + 0.480 0.289 -1.095
ENSG00000078699 E015 21.4018572 0.0008920393 1.587294e-01 2.734406e-01 20 33619517 33619564 48 + 1.372 1.319 -0.183
ENSG00000078699 E016 21.9764324 0.0010695482 6.619363e-02 1.370362e-01 20 33619565 33619606 42 + 1.396 1.313 -0.289
ENSG00000078699 E017 41.3201834 0.0005074683 8.799433e-03 2.578261e-02 20 33623115 33623296 182 + 1.666 1.578 -0.300
ENSG00000078699 E018 1.9218742 0.0073309837 7.462445e-01 8.340636e-01 20 33623773 33623854 82 + 0.480 0.461 -0.096
ENSG00000078699 E019 1.5113482 0.0097818284 4.714200e-01 6.105312e-01 20 33623855 33623954 100 + 0.303 0.461 0.905
ENSG00000078699 E020 74.2979280 0.0004239746 7.331375e-04 3.018510e-03 20 33624764 33625017 254 + 1.916 1.833 -0.278
ENSG00000078699 E021 49.3968580 0.0014211942 5.201721e-02 1.127518e-01 20 33628350 33628435 86 + 1.720 1.673 -0.160
ENSG00000078699 E022 68.6976109 0.0003854217 9.361618e-02 1.807788e-01 20 33629719 33629914 196 + 1.845 1.827 -0.059
ENSG00000078699 E023 40.0511794 0.0015032180 8.661303e-01 9.177959e-01 20 33636640 33636708 69 + 1.568 1.630 0.211
ENSG00000078699 E024 1.4780388 0.0142874687 5.464349e-01 6.766131e-01 20 33638739 33639708 970 + 0.428 0.354 -0.416
ENSG00000078699 E025 18.8994034 0.0010105172 7.368711e-01 8.271999e-01 20 33640341 33640343 3 + 1.275 1.299 0.085
ENSG00000078699 E026 64.5881510 0.0100733778 7.359511e-01 8.265899e-01 20 33640344 33640531 188 + 1.762 1.840 0.264
ENSG00000078699 E027 751.7462067 0.0027664294 1.037584e-09 1.534483e-08 20 33644347 33650167 5821 + 2.788 2.928 0.467