ENSG00000078687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000588061 ENSG00000078687 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6C protein_coding protein_coding 4.793242 4.226951 4.327893 0.2760889 0.1338994 0.033968 0.5663667 1.5652159 0.03638677 0.19737727 0.03638677 -5.08569243 0.1237583 0.37970000 0.008533333 -0.37116667 3.265546e-06 1.517986e-24 FALSE TRUE
ENST00000588549 ENSG00000078687 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6C protein_coding protein_coding 4.793242 4.226951 4.327893 0.2760889 0.1338994 0.033968 0.8781678 0.0000000 1.43446316 0.00000000 0.06553483 7.17438960 0.1713958 0.00000000 0.331433333 0.33143333 1.517986e-24 1.517986e-24 FALSE TRUE
ENST00000636222 ENSG00000078687 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6C protein_coding protein_coding 4.793242 4.226951 4.327893 0.2760889 0.1338994 0.033968 0.7111919 1.0388171 0.00000000 0.02380555 0.00000000 -6.71261930 0.1482333 0.24776667 0.000000000 -0.24776667 1.847820e-18 1.517986e-24 FALSE TRUE
ENST00000696270 ENSG00000078687 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6C protein_coding protein_coding 4.793242 4.226951 4.327893 0.2760889 0.1338994 0.033968 0.7637746 0.2354510 1.72428026 0.08777811 0.16813471 2.82083032 0.1693958 0.05376667 0.399433333 0.34566667 6.758029e-07 1.517986e-24 FALSE TRUE
ENST00000696541 ENSG00000078687 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6C protein_coding protein_coding 4.793242 4.226951 4.327893 0.2760889 0.1338994 0.033968 1.3421907 0.9394484 0.98164312 0.31026019 0.19859988 0.06273143 0.2803875 0.21450000 0.227166667 0.01266667 9.548570e-01 1.517986e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078687 E001 11.9963282 0.0014355328 1.801275e-20 1.216998e-18 17 77958703 77959155 453 + 1.420 0.410 -4.008
ENSG00000078687 E002 5.2068602 0.0031518757 1.514439e-06 1.209859e-05 17 77959156 77959179 24 + 1.032 0.410 -2.637
ENSG00000078687 E003 9.0034808 0.0018918492 3.205077e-05 1.893216e-04 17 77959180 77959239 60 + 1.181 0.780 -1.494
ENSG00000078687 E004 9.9676251 0.0017067023 2.544788e-04 1.193884e-03 17 77959240 77959268 29 + 1.190 0.862 -1.206
ENSG00000078687 E005 0.1482932 0.0421885732 5.814277e-01   17 78004167 78004169 3 + 0.000 0.118 9.902
ENSG00000078687 E006 21.2485057 0.0009369265 1.471960e-01 2.578655e-01 17 78004170 78004269 100 + 1.366 1.312 -0.191
ENSG00000078687 E007 16.2235429 0.0064383561 7.545499e-01 8.401628e-01 17 78005058 78005079 22 + 1.209 1.233 0.087
ENSG00000078687 E008 7.7759676 0.0051211767 5.461695e-03 1.718659e-02 17 78012003 78012060 58 + 0.673 1.068 1.527
ENSG00000078687 E009 8.0895010 0.0505032042 1.648313e-01 2.814696e-01 17 78031516 78031521 6 + 1.032 0.869 -0.611
ENSG00000078687 E010 30.5429428 0.0102859954 2.152153e-05 1.324322e-04 17 78031522 78031842 321 + 1.624 1.347 -0.953
ENSG00000078687 E011 0.0000000       17 78041047 78041117 71 +      
ENSG00000078687 E012 17.2936868 0.0010393430 6.738358e-05 3.674934e-04 17 78048845 78048912 68 + 1.385 1.112 -0.961
ENSG00000078687 E013 214.9837265 0.0075824462 1.956226e-08 2.286109e-07 17 78048913 78051066 2154 + 2.421 2.243 -0.596
ENSG00000078687 E014 51.4627641 0.0051646202 7.573260e-03 2.270252e-02 17 78051067 78051448 382 + 1.766 1.667 -0.334
ENSG00000078687 E015 0.5901394 0.2856208089 7.441475e-01 8.325828e-01 17 78051449 78051457 9 + 0.126 0.218 0.951
ENSG00000078687 E016 8.0446234 0.0029403880 5.040746e-01 6.399682e-01 17 78064722 78064730 9 + 0.959 0.932 -0.100
ENSG00000078687 E017 21.2837777 0.0021693047 2.839379e-01 4.241338e-01 17 78064731 78064893 163 + 1.354 1.325 -0.099
ENSG00000078687 E018 15.0945167 0.0012900208 9.765296e-01 9.893345e-01 17 78064894 78064937 44 + 1.161 1.215 0.193
ENSG00000078687 E019 29.9422792 0.0007254414 5.235222e-01 6.571935e-01 17 78067757 78067923 167 + 1.425 1.519 0.324
ENSG00000078687 E020 24.3156616 0.0012476200 9.813356e-01 9.923620e-01 17 78071085 78071165 81 + 1.373 1.427 0.189
ENSG00000078687 E021 19.1399295 0.0009681032 8.310867e-01 8.941063e-01 17 78073037 78073094 58 + 1.276 1.311 0.125
ENSG00000078687 E022 29.9210890 0.0010793521 6.755756e-01 7.808058e-01 17 78075136 78075278 143 + 1.431 1.511 0.277
ENSG00000078687 E023 0.2934659 0.0298362383 8.854697e-01   17 78075279 78075385 107 + 0.126 0.118 -0.104
ENSG00000078687 E024 0.8051678 0.0170278055 2.469598e-01 3.823653e-01 17 78077161 78077184 24 + 0.126 0.353 1.896
ENSG00000078687 E025 30.6229130 0.0006838051 1.047316e-01 1.977149e-01 17 78077185 78077334 150 + 1.519 1.471 -0.163
ENSG00000078687 E026 0.2966881 0.0271855173 1.520392e-01   17 78077335 78077779 445 + 0.224 0.000 -12.184
ENSG00000078687 E027 24.7675032 0.0010320066 2.655539e-01 4.036271e-01 17 78079395 78079541 147 + 1.420 1.396 -0.083
ENSG00000078687 E028 24.3450092 0.0224959292 2.473453e-01 3.828148e-01 17 78083047 78083166 120 + 1.426 1.367 -0.202
ENSG00000078687 E029 21.8672241 0.0009258975 2.305965e-01 3.631676e-01 17 78086503 78086586 84 + 1.366 1.331 -0.123
ENSG00000078687 E030 33.2292939 0.0006136494 2.669766e-01 4.052468e-01 17 78086853 78087093 241 + 1.536 1.523 -0.044
ENSG00000078687 E031 0.0000000       17 78091367 78091439 73 +      
ENSG00000078687 E032 33.5445544 0.0006451741 4.445599e-01 5.861103e-01 17 78091440 78091607 168 + 1.528 1.535 0.027
ENSG00000078687 E033 41.7642010 0.0036010412 6.691827e-01 7.760517e-01 17 78092933 78093124 192 + 1.614 1.643 0.099
ENSG00000078687 E034 0.2214452 0.0384052590 5.797479e-01   17 78093125 78093299 175 + 0.000 0.119 9.934
ENSG00000078687 E035 45.6288353 0.0005785287 6.597494e-01 7.685157e-01 17 78093620 78093763 144 + 1.648 1.679 0.106
ENSG00000078687 E036 20.7188696 0.0009078704 2.741108e-01 4.132242e-01 17 78097745 78097861 117 + 1.347 1.318 -0.101
ENSG00000078687 E037 0.1515154 0.0429845723 4.066575e-01   17 78098342 78098342 1 + 0.126 0.000 -11.060
ENSG00000078687 E038 60.8775346 0.0004082319 4.365743e-01 5.786465e-01 17 78098343 78098537 195 + 1.771 1.790 0.066
ENSG00000078687 E039 39.3969785 0.0076199501 2.112774e-01 3.400032e-01 17 78102474 78102544 71 + 1.610 1.582 -0.097
ENSG00000078687 E040 0.0000000       17 78102545 78102821 277 +      
ENSG00000078687 E041 52.4996679 0.0136707902 8.714119e-01 9.212974e-01 17 78103414 78103553 140 + 1.673 1.748 0.253
ENSG00000078687 E042 415.6141775 0.0075496241 1.432613e-21 1.089539e-19 17 78104485 78108822 4338 + 2.347 2.748 1.337