ENSG00000078668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000022615 ENSG00000078668 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC3 protein_coding protein_coding 134.9501 98.8445 175.4393 22.26922 5.388775 0.8276759 116.35440 91.602237 146.45065 21.325591 3.986527 0.6769009 0.86825000 0.92376667 0.8349667 -0.08880000 4.797927e-07 4.797927e-07 FALSE  
MSTRG.31451.4 ENSG00000078668 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC3 protein_coding   134.9501 98.8445 175.4393 22.26922 5.388775 0.8276759 11.83927 2.810992 21.10377 1.408988 2.083504 2.9039097 0.07827917 0.03666667 0.1200333 0.08336667 5.497417e-01 4.797927e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078668 E001 0.4751703 2.083368e-02 3.617085e-01 5.061199e-01 8 42391624 42391642 19 + 0.102 0.256 1.608
ENSG00000078668 E002 0.6224193 1.827925e-02 6.982301e-01 7.982475e-01 8 42391643 42391666 24 + 0.184 0.256 0.608
ENSG00000078668 E003 2.8679232 6.564090e-03 7.242496e-01 8.178324e-01 8 42391667 42391749 83 + 0.560 0.625 0.287
ENSG00000078668 E004 7.5588324 9.087880e-03 4.523442e-01 5.932068e-01 8 42391750 42391841 92 + 0.880 0.976 0.360
ENSG00000078668 E005 6.5353635 5.098180e-02 2.048877e-01 3.322578e-01 8 42391842 42391845 4 + 0.779 0.960 0.695
ENSG00000078668 E006 11.4286182 1.913009e-02 3.478809e-01 4.921001e-01 8 42391846 42391855 10 + 1.042 1.143 0.364
ENSG00000078668 E007 18.9743219 4.842107e-03 4.465694e-01 5.880563e-01 8 42391856 42391863 8 + 1.323 1.262 -0.213
ENSG00000078668 E008 60.6131487 3.954238e-04 2.670771e-03 9.284698e-03 8 42391864 42391879 16 + 1.844 1.716 -0.431
ENSG00000078668 E009 89.2216402 6.897999e-04 4.274074e-05 2.447672e-04 8 42391880 42391886 7 + 2.017 1.863 -0.519
ENSG00000078668 E010 104.2392987 1.103388e-03 8.882095e-06 5.976722e-05 8 42391887 42391889 3 + 2.088 1.922 -0.555
ENSG00000078668 E011 197.2580413 6.358314e-04 1.241179e-08 1.504400e-07 8 42391890 42391901 12 + 2.360 2.206 -0.516
ENSG00000078668 E012 198.5437666 8.232351e-04 4.144516e-08 4.545364e-07 8 42391902 42391902 1 + 2.363 2.209 -0.514
ENSG00000078668 E013 302.3102256 6.577259e-04 5.062320e-09 6.600423e-08 8 42391903 42391928 26 + 2.538 2.403 -0.449
ENSG00000078668 E014 3.2569329 1.635985e-01 7.182502e-01 8.134190e-01 8 42393811 42393844 34 + 0.672 0.576 -0.418
ENSG00000078668 E015 466.0991834 3.014613e-03 6.264902e-03 1.930712e-02 8 42393845 42393884 40 + 2.708 2.615 -0.311
ENSG00000078668 E016 560.2271134 9.356402e-04 1.525435e-05 9.719473e-05 8 42394210 42394242 33 + 2.788 2.699 -0.296
ENSG00000078668 E017 613.0042786 6.066297e-04 2.915086e-06 2.186927e-05 8 42394243 42394278 36 + 2.825 2.744 -0.269
ENSG00000078668 E018 675.0851563 2.202284e-04 2.403136e-05 1.463881e-04 8 42395084 42395133 50 + 2.858 2.804 -0.178
ENSG00000078668 E019 1.8551536 9.014657e-03 6.200270e-01 7.373049e-01 8 42396656 42396677 22 + 0.493 0.416 -0.393
ENSG00000078668 E020 6.6330408 2.960753e-03 8.216420e-04 3.336855e-03 8 42396678 42396680 3 + 1.021 0.581 -1.754
ENSG00000078668 E021 6.6869637 2.413748e-03 1.880438e-03 6.854394e-03 8 42396681 42397599 919 + 1.021 0.625 -1.561
ENSG00000078668 E022 1220.4235162 6.574952e-04 4.036494e-05 2.324109e-04 8 42398712 42398864 153 + 3.114 3.056 -0.191
ENSG00000078668 E023 3.0952733 2.443480e-01 6.746780e-01 7.801395e-01 8 42399550 42399650 101 + 0.594 0.625 0.138
ENSG00000078668 E024 740.0648135 1.083361e-04 4.177886e-04 1.842598e-03 8 42399651 42399703 53 + 2.891 2.854 -0.121
ENSG00000078668 E025 748.9416091 9.262695e-05 5.106641e-02 1.110721e-01 8 42401788 42401836 49 + 2.886 2.872 -0.047
ENSG00000078668 E026 1008.9128805 8.059601e-05 2.957830e-01 4.369318e-01 8 42401837 42402015 179 + 3.000 3.023 0.079
ENSG00000078668 E027 8.8535791 3.192297e-03 1.121574e-02 3.168393e-02 8 42402016 42402164 149 + 1.100 0.821 -1.045
ENSG00000078668 E028 13.9408249 1.236422e-03 7.798771e-05 4.185066e-04 8 42403032 42403310 279 + 1.306 0.936 -1.334
ENSG00000078668 E029 1058.4164498 1.658438e-04 9.743340e-06 6.496388e-05 8 42403311 42403461 151 + 3.002 3.066 0.213
ENSG00000078668 E030 726.1388260 1.666865e-04 6.177935e-08 6.537038e-07 8 42404867 42404924 58 + 2.828 2.915 0.292
ENSG00000078668 E031 484.9621879 1.627020e-04 4.991755e-04 2.156855e-03 8 42405371 42405373 3 + 2.661 2.732 0.235
ENSG00000078668 E032 775.1561372 1.289636e-04 1.201819e-16 5.114131e-15 8 42405374 42405432 59 + 2.839 2.961 0.405
ENSG00000078668 E033 1695.8775429 1.533037e-03 4.359970e-12 9.622359e-11 8 42405433 42405937 505 + 3.165 3.301 0.450