ENSG00000078618

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352171 ENSG00000078618 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDC protein_coding protein_coding 52.8862 34.16492 63.8618 5.127314 0.7780684 0.9022414 36.727667 17.303835 49.3744610 0.9591218 0.74854226 1.5121318 0.65551250 0.5295667 0.773133333 0.24356667 2.199554e-02 2.246236e-09 FALSE TRUE
ENST00000440943 ENSG00000078618 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDC protein_coding protein_coding 52.8862 34.16492 63.8618 5.127314 0.7780684 0.9022414 2.518539 6.063317 0.6153182 3.0771827 0.07209788 -3.2798223 0.06143750 0.1603333 0.009633333 -0.15070000 1.470298e-07 2.246236e-09 FALSE TRUE
ENST00000464385 ENSG00000078618 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDC protein_coding processed_transcript 52.8862 34.16492 63.8618 5.127314 0.7780684 0.9022414 3.893503 3.834315 3.3414673 0.1409281 0.54934382 -0.1979338 0.08952917 0.1174000 0.052233333 -0.06516667 2.329358e-02 2.246236e-09   FALSE
ENST00000485608 ENSG00000078618 HEK293_OSMI2_2hA HEK293_TMG_2hB NRDC protein_coding processed_transcript 52.8862 34.16492 63.8618 5.127314 0.7780684 0.9022414 3.019239 5.506700 0.6759327 2.3226864 0.67593268 -3.0076665 0.07365000 0.1497333 0.010800000 -0.13893333 3.427197e-02 2.246236e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078618 E001 0.8845503 0.1071778784 6.138608e-01 7.324721e-01 1 51789191 51789195 5 - 0.239 0.357 0.800
ENSG00000078618 E002 2.0959776 0.1978820344 6.126200e-01 7.315136e-01 1 51789196 51789209 14 - 0.432 0.590 0.762
ENSG00000078618 E003 3.4975404 0.1190284541 1.761245e-01 2.961783e-01 1 51789210 51789211 2 - 0.505 0.831 1.396
ENSG00000078618 E004 19.5800591 0.0010530951 2.195931e-03 7.829352e-03 1 51789212 51789216 5 - 1.202 1.451 0.868
ENSG00000078618 E005 289.3143788 0.0091589749 4.700130e-10 7.392491e-09 1 51789217 51789408 192 - 2.287 2.628 1.138
ENSG00000078618 E006 262.7017046 0.0085036037 1.990044e-08 2.321049e-07 1 51789409 51789433 25 - 2.267 2.572 1.014
ENSG00000078618 E007 443.0628703 0.0101229572 3.589579e-06 2.641220e-05 1 51789568 51789657 90 - 2.516 2.778 0.872
ENSG00000078618 E008 20.5493162 0.0071290265 9.689181e-02 1.857405e-01 1 51789658 51789822 165 - 1.259 1.409 0.525
ENSG00000078618 E009 497.4611832 0.0099157573 4.210064e-05 2.414141e-04 1 51790533 51790649 117 - 2.584 2.813 0.760
ENSG00000078618 E010 402.0745124 0.0031593842 8.309376e-08 8.574814e-07 1 51790900 51790990 91 - 2.516 2.704 0.628
ENSG00000078618 E011 388.7719102 0.0019719179 2.961902e-07 2.744014e-06 1 51791578 51791661 84 - 2.517 2.674 0.523
ENSG00000078618 E012 288.8044918 0.0018015639 7.869064e-06 5.353818e-05 1 51792046 51792098 53 - 2.395 2.541 0.487
ENSG00000078618 E013 232.9145049 0.0005491346 5.187978e-11 9.612194e-10 1 51792377 51792424 48 - 2.285 2.467 0.608
ENSG00000078618 E014 374.6257591 0.0001913182 6.980885e-16 2.692950e-14 1 51794472 51794610 139 - 2.497 2.665 0.559
ENSG00000078618 E015 201.5527689 0.0001789862 1.189014e-08 1.445611e-07 1 51794823 51794854 32 - 2.232 2.391 0.530
ENSG00000078618 E016 19.8491666 0.0015680571 1.891419e-02 4.914266e-02 1 51794855 51795708 854 - 1.376 1.196 -0.629
ENSG00000078618 E017 438.2723742 0.0001242584 1.302983e-03 4.986993e-03 1 51798249 51798411 163 - 2.610 2.681 0.235
ENSG00000078618 E018 371.5883712 0.0010486330 3.954600e-01 5.392667e-01 1 51800556 51800683 128 - 2.554 2.588 0.111
ENSG00000078618 E019 0.0000000       1 51800857 51801094 238 -      
ENSG00000078618 E020 375.3423823 0.0001540058 3.566462e-02 8.293102e-02 1 51803814 51803964 151 - 2.550 2.604 0.181
ENSG00000078618 E021 223.4146388 0.0002637830 6.346679e-01 7.490776e-01 1 51805510 51805561 52 - 2.336 2.362 0.087
ENSG00000078618 E022 298.7555676 0.0013470915 6.796956e-01 7.838030e-01 1 51806794 51806913 120 - 2.463 2.483 0.067
ENSG00000078618 E023 239.3403308 0.0046263213 3.943672e-01 5.382183e-01 1 51809315 51809401 87 - 2.387 2.354 -0.112
ENSG00000078618 E024 131.4249452 0.0053957842 1.775491e-01 2.980607e-01 1 51810281 51810290 10 - 2.139 2.079 -0.203
ENSG00000078618 E025 248.8963676 0.0052842658 1.104923e-01 2.062471e-01 1 51810291 51810404 114 - 2.417 2.350 -0.222
ENSG00000078618 E026 231.5885683 0.0013736893 6.910413e-03 2.099253e-02 1 51811994 51812098 105 - 2.389 2.317 -0.240
ENSG00000078618 E027 178.4185134 0.0019172742 8.700410e-02 1.705994e-01 1 51814035 51814089 55 - 2.268 2.217 -0.168
ENSG00000078618 E028 0.1482932 0.0411597534 2.873526e-01   1 51814090 51814550 461 - 0.000 0.156 10.131
ENSG00000078618 E029 179.3976467 0.0030897844 1.031376e-02 2.954098e-02 1 51814551 51814609 59 - 2.285 2.191 -0.314
ENSG00000078618 E030 0.6685028 0.0177023566 5.983461e-01 7.199649e-01 1 51814610 51814625 16 - 0.173 0.271 0.823
ENSG00000078618 E031 244.3596358 0.0066757053 2.214531e-02 5.597915e-02 1 51814693 51814813 121 - 2.423 2.318 -0.350
ENSG00000078618 E032 11.8327791 0.0466907427 2.146138e-03 7.678699e-03 1 51815929 51816311 383 - 1.235 0.762 -1.760
ENSG00000078618 E033 218.5516335 0.0007616028 5.056453e-06 3.594483e-05 1 51816312 51816389 78 - 2.380 2.264 -0.388
ENSG00000078618 E034 231.6462602 0.0012238313 1.568711e-08 1.864180e-07 1 51818066 51818135 70 - 2.418 2.260 -0.529
ENSG00000078618 E035 240.5866219 0.0003727771 3.735605e-11 7.078407e-10 1 51819800 51819873 74 - 2.435 2.281 -0.516
ENSG00000078618 E036 208.0650443 0.0002115863 2.486729e-13 6.688008e-12 1 51821498 51821555 58 - 2.381 2.202 -0.598
ENSG00000078618 E037 238.8076839 0.0011723640 4.419201e-08 4.816779e-07 1 51823664 51823786 123 - 2.429 2.279 -0.500
ENSG00000078618 E038 125.5756103 0.0067963629 3.920561e-03 1.291966e-02 1 51825287 51825296 10 - 2.150 1.999 -0.506
ENSG00000078618 E039 203.5374169 0.0061892307 1.886167e-03 6.871310e-03 1 51825297 51825382 86 - 2.357 2.212 -0.484
ENSG00000078618 E040 218.2268426 0.0028927326 2.140725e-07 2.040420e-06 1 51827796 51827869 74 - 2.400 2.215 -0.616
ENSG00000078618 E041 295.2613727 0.0032214910 5.747992e-08 6.112832e-07 1 51834017 51834170 154 - 2.532 2.344 -0.627
ENSG00000078618 E042 233.1510324 0.0053217424 5.793801e-07 5.064767e-06 1 51836131 51836212 82 - 2.438 2.222 -0.720
ENSG00000078618 E043 0.0000000       1 51836344 51836368 25 -      
ENSG00000078618 E044 18.0938142 0.0206253503 3.168706e-03 1.076350e-02 1 51836369 51836438 70 - 1.381 1.055 -1.154
ENSG00000078618 E045 1.9971938 0.0070868561 1.575761e-02 4.219010e-02 1 51837456 51837486 31 - 0.595 0.156 -2.761
ENSG00000078618 E046 18.3814508 0.0036410845 1.556949e-04 7.724481e-04 1 51837487 51837620 134 - 1.389 1.056 -1.178
ENSG00000078618 E047 3.3935492 0.0102622415 4.470691e-02 9.966333e-02 1 51839992 51840225 234 - 0.752 0.436 -1.428
ENSG00000078618 E048 476.9005594 0.0023606276 6.170999e-24 6.092117e-22 1 51840226 51840514 289 - 2.769 2.477 -0.972
ENSG00000078618 E049 0.2903454 0.3023245162 4.980054e-01   1 51862114 51862418 305 - 0.173 0.000 -9.759
ENSG00000078618 E050 1.5468002 0.1361136123 1.151040e-01 2.129940e-01 1 51877983 51878274 292 - 0.505 0.157 -2.331
ENSG00000078618 E051 390.1437893 0.0157546229 2.766844e-07 2.578690e-06 1 51878275 51878661 387 - 2.692 2.356 -1.118
ENSG00000078618 E052 89.3734558 0.0458898497 2.169395e-03 7.748008e-03 1 51878662 51878805 144 - 2.059 1.708 -1.181