ENSG00000078403

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377100 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding protein_coding 15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 1.5142014 2.22290349 0.462010 0.16801160 0.4620100 -2.242031 0.10472917 0.1160333 0.03333333 -0.0827000 1.456434e-01 6.440243e-17 FALSE TRUE
ENST00000471315 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding retained_intron 15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 0.6165389 2.98104354 0.000000 1.71448435 0.0000000 -8.224505 0.03403333 0.1382333 0.00000000 -0.1382333 1.929322e-01 6.440243e-17   FALSE
ENST00000652497 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding protein_coding 15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 6.2639016 11.56435897 4.833986 0.49606837 0.8036112 -1.256666 0.40837500 0.5931000 0.32173333 -0.2713667 4.247815e-03 6.440243e-17 FALSE TRUE
MSTRG.3647.10 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding   15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 2.0179256 0.64669327 2.769501 0.25014511 0.3356760 2.081534 0.12668333 0.0330000 0.18840000 0.1554000 2.842670e-04 6.440243e-17 FALSE TRUE
MSTRG.3647.11 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding   15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 0.7888153 0.00000000 1.508446 0.00000000 0.2837366 7.246452 0.05231667 0.0000000 0.10203333 0.1020333 1.051161e-14 6.440243e-17 FALSE TRUE
MSTRG.3647.14 ENSG00000078403 HEK293_OSMI2_2hA HEK293_TMG_2hB MLLT10 protein_coding   15.54435 19.72327 14.87809 1.686692 0.5750231 -0.4064716 1.5675014 0.01622486 1.679976 0.01622486 0.2213257 6.009924 0.09592083 0.0010000 0.11330000 0.1123000 6.440243e-17 6.440243e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078403 E001 0.4031496 0.0256442288 6.813286e-02 1.402676e-01 10 21524646 21524674 29 + 0.000 0.286 12.008
ENSG00000078403 E002 1.1489717 0.0113592226 5.896827e-01 7.127139e-01 10 21524675 21524775 101 + 0.282 0.379 0.608
ENSG00000078403 E003 0.1515154 0.0430294191 1.000000e+00   10 21533349 21533841 493 + 0.089 0.000 -13.301
ENSG00000078403 E004 2.1067732 0.0136450078 7.817259e-02 1.565284e-01 10 21534232 21534344 113 + 0.331 0.629 1.512
ENSG00000078403 E005 1.8477521 0.0157423589 8.110716e-01 8.801565e-01 10 21534345 21534439 95 + 0.415 0.456 0.219
ENSG00000078403 E006 0.1472490 0.0432087972 1.000000e+00   10 21534440 21534440 1 + 0.089 0.000 -13.299
ENSG00000078403 E007 1.7672383 0.0082109867 3.968333e-01 5.405985e-01 10 21534441 21534451 11 + 0.375 0.521 0.760
ENSG00000078403 E008 10.8936095 0.0202613222 1.637085e-02 4.354443e-02 10 21534452 21534465 14 + 0.943 1.231 1.046
ENSG00000078403 E009 12.5553141 0.0220277676 5.081218e-03 1.615137e-02 10 21534466 21534467 2 + 0.975 1.305 1.185
ENSG00000078403 E010 27.6858712 0.0131723237 6.740865e-07 5.806823e-06 10 21534468 21534475 8 + 1.241 1.666 1.466
ENSG00000078403 E011 39.3055618 0.0006126916 1.359226e-16 5.752280e-15 10 21534476 21534489 14 + 1.364 1.825 1.572
ENSG00000078403 E012 41.5177523 0.0005556038 7.842157e-18 3.904529e-16 10 21534490 21534494 5 + 1.381 1.849 1.593
ENSG00000078403 E013 24.6886331 0.0030514329 6.060712e-09 7.792750e-08 10 21534495 21534520 26 + 1.193 1.616 1.463
ENSG00000078403 E014 67.4937577 0.0004007137 5.212289e-24 5.169908e-22 10 21534645 21534701 57 + 1.610 2.041 1.456
ENSG00000078403 E015 69.9631263 0.0003764931 2.796142e-22 2.294157e-20 10 21534702 21534748 47 + 1.638 2.045 1.373
ENSG00000078403 E016 77.2226443 0.0003908618 2.866259e-29 4.517505e-27 10 21534749 21534804 56 + 1.652 2.103 1.520
ENSG00000078403 E017 89.2867632 0.0003712515 9.725456e-30 1.602138e-27 10 21538833 21538912 80 + 1.739 2.159 1.411
ENSG00000078403 E018 0.0000000       10 21538913 21538964 52 +      
ENSG00000078403 E019 0.2214452 0.0409061839 2.391924e-01   10 21541263 21541361 99 + 0.000 0.166 13.469
ENSG00000078403 E020 5.4206463 0.0031370058 4.364017e-03 1.415963e-02 10 21551816 21551921 106 + 0.623 0.992 1.463
ENSG00000078403 E021 163.1365652 0.0002418483 6.773532e-158 8.554835e-154 10 21556643 21557182 540 + 1.755 2.521 2.564
ENSG00000078403 E022 4.5502130 0.0055690078 6.229345e-04 2.616698e-03 10 21557621 21557824 204 + 0.869 0.285 -2.784
ENSG00000078403 E023 0.2924217 0.0271193771 4.766157e-01   10 21571975 21571984 10 + 0.163 0.000 -14.402
ENSG00000078403 E024 0.1451727 0.0433086514 1.000000e+00   10 21571985 21572026 42 + 0.089 0.000 -13.298
ENSG00000078403 E025 17.1717116 0.0118536804 3.083249e-05 1.829123e-04 10 21586294 21586348 55 + 1.368 0.901 -1.682
ENSG00000078403 E026 21.5656973 0.0013780861 4.424107e-06 3.187184e-05 10 21595331 21595440 110 + 1.450 1.050 -1.412
ENSG00000078403 E027 0.0000000       10 21595441 21595582 142 +      
ENSG00000078403 E028 0.2965864 0.1526114947 8.968699e-02   10 21611031 21612347 1317 + 0.000 0.282 13.849
ENSG00000078403 E029 29.9108040 0.0006537379 1.070915e-12 2.612770e-11 10 21612348 21612451 104 + 1.615 1.049 -1.977
ENSG00000078403 E030 28.4545926 0.0025904343 3.649175e-08 4.039767e-07 10 21614831 21614924 94 + 1.574 1.131 -1.544
ENSG00000078403 E031 18.3980150 0.0013836614 2.576633e-07 2.416512e-06 10 21617112 21617133 22 + 1.401 0.901 -1.798
ENSG00000078403 E032 17.6917935 0.0010047687 8.529675e-04 3.448108e-03 10 21617134 21617207 74 + 1.351 1.049 -1.073
ENSG00000078403 E033 0.0000000       10 21624667 21624690 24 +      
ENSG00000078403 E034 0.0000000       10 21624691 21624749 59 +      
ENSG00000078403 E035 23.9403842 0.0014866866 3.083047e-04 1.413299e-03 10 21651673 21651768 96 + 1.474 1.187 -1.001
ENSG00000078403 E036 0.0000000       10 21663750 21663843 94 +      
ENSG00000078403 E037 1.7212565 0.2404574860 7.367343e-01 8.271409e-01 10 21668917 21668971 55 + 0.451 0.381 -0.378
ENSG00000078403 E038 2.6833269 0.0730954821 4.843885e-01 6.224036e-01 10 21668972 21669052 81 + 0.598 0.458 -0.665
ENSG00000078403 E039 49.3703188 0.0032485420 1.043420e-16 4.476285e-15 10 21670449 21670704 256 + 1.829 1.259 -1.954
ENSG00000078403 E040 1.4780137 0.0105724203 4.861757e-01 6.239764e-01 10 21670705 21671014 310 + 0.415 0.285 -0.782
ENSG00000078403 E041 34.6833144 0.0079610633 1.402579e-11 2.851013e-10 10 21673350 21673528 179 + 1.681 1.084 -2.077
ENSG00000078403 E042 19.7070400 0.0015114037 2.352207e-10 3.891866e-09 10 21673529 21673577 49 + 1.450 0.817 -2.287
ENSG00000078403 E043 22.1624627 0.0009931622 1.180851e-08 1.436608e-07 10 21673578 21673640 63 + 1.480 0.971 -1.807
ENSG00000078403 E044 18.6335416 0.0150763432 5.477281e-05 3.055876e-04 10 21673641 21673643 3 + 1.401 0.948 -1.619
ENSG00000078403 E045 29.1708646 0.0054371411 9.735841e-08 9.907745e-07 10 21673644 21673781 138 + 1.585 1.132 -1.578
ENSG00000078403 E046 27.8756150 0.0007983471 3.460231e-08 3.850399e-07 10 21673782 21673919 138 + 1.561 1.131 -1.498
ENSG00000078403 E047 19.5986490 0.0009356159 9.504927e-07 7.920995e-06 10 21681332 21681376 45 + 1.421 0.971 -1.602
ENSG00000078403 E048 11.2365150 0.0165642730 1.636094e-07 1.595394e-06 10 21682225 21682257 33 + 1.236 0.456 -3.129
ENSG00000078403 E049 4.5939928 0.0039974615 5.837839e-04 2.474075e-03 10 21688491 21688538 48 + 0.869 0.285 -2.784
ENSG00000078403 E050 0.0000000       10 21708588 21708657 70 +      
ENSG00000078403 E051 0.3289534 0.0294692578 6.024485e-01   10 21712230 21712340 111 + 0.089 0.166 1.024
ENSG00000078403 E052 43.5240501 0.0049210920 1.601084e-12 3.791982e-11 10 21713772 21713950 179 + 1.764 1.237 -1.811
ENSG00000078403 E053 40.0166911 0.0075567228 2.766162e-11 5.361034e-10 10 21726244 21726355 112 + 1.732 1.188 -1.879
ENSG00000078403 E054 31.0565560 0.0006661329 4.499765e-13 1.168243e-11 10 21727856 21727928 73 + 1.631 1.067 -1.969
ENSG00000078403 E055 47.8833736 0.0005011225 3.306008e-11 6.321289e-10 10 21730900 21731054 155 + 1.784 1.392 -1.338
ENSG00000078403 E056 46.2561442 0.0005124748 2.698222e-09 3.696095e-08 10 21732899 21733087 189 + 1.761 1.408 -1.203
ENSG00000078403 E057 27.1312319 0.0045373033 7.954544e-08 8.237930e-07 10 21733504 21733592 89 + 1.558 1.100 -1.602
ENSG00000078403 E058 76.6524454 0.0003507708 2.221340e-17 1.035243e-15 10 21733768 21734129 362 + 1.985 1.586 -1.348
ENSG00000078403 E059 40.7456466 0.0005293223 3.979955e-08 4.379083e-07 10 21735139 21735235 97 + 1.704 1.358 -1.184
ENSG00000078403 E060 42.8788994 0.0005360485 4.925416e-08 5.317748e-07 10 21740030 21740153 124 + 1.725 1.392 -1.137
ENSG00000078403 E061 33.6785727 0.0023899281 3.961456e-05 2.285489e-04 10 21740154 21740236 83 + 1.612 1.321 -1.001
ENSG00000078403 E062 185.2922523 0.0008773876 8.878919e-07 7.456709e-06 10 21741939 21743630 1692 + 2.304 2.158 -0.488