ENSG00000078304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328724 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding protein_coding 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 4.099028 3.319219 2.742470 0.26877462 1.3837995 -0.2744567 0.07410833 0.08893333 0.03596667 -0.052966667 6.126271e-01 2.929626e-11 FALSE TRUE
ENST00000350249 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding protein_coding 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 4.186621 1.121870 9.968400 0.27720597 0.8579916 3.1401006 0.06560417 0.02926667 0.12613333 0.096866667 2.929626e-11 2.929626e-11 FALSE TRUE
ENST00000445439 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding protein_coding 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 21.033862 12.891979 33.507806 0.75028405 0.5851110 1.3773353 0.36540000 0.34953333 0.42590000 0.076366667 3.117803e-01 2.929626e-11 FALSE TRUE
ENST00000553730 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding retained_intron 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 3.518477 1.078039 4.331183 0.09317549 0.4863829 1.9963572 0.06197083 0.02886667 0.05550000 0.026633333 3.616641e-02 2.929626e-11 FALSE TRUE
ENST00000556260 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding protein_coding 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 7.519787 8.965367 7.964379 1.29906240 0.2363890 -0.1705989 0.15973750 0.23786667 0.10116667 -0.136700000 9.992476e-10 2.929626e-11   FALSE
ENST00000694906 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding protein_coding 55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 3.606689 1.464390 7.317516 0.29886349 0.7366606 2.3132066 0.05952083 0.03843333 0.09253333 0.054100000 3.240198e-05 2.929626e-11 FALSE TRUE
MSTRG.10194.19 ENSG00000078304 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5C protein_coding   55.43219 37.39937 78.75039 3.139091 2.564761 1.074071 4.651438 2.636048 5.703988 0.90927377 1.6000925 1.1106588 0.07672500 0.06766667 0.07133333 0.003666667 9.741480e-01 2.929626e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078304 E001 5.5136889 0.0145251925 3.410727e-01 4.849841e-01 14 101761709 101761797 89 + 0.850 0.718 -0.529
ENSG00000078304 E002 6.0403561 0.0796061789 2.190750e-01 3.492674e-01 14 101761798 101761841 44 + 0.903 0.679 -0.888
ENSG00000078304 E003 11.0976968 0.0016351775 7.278808e-01 8.204512e-01 14 101761842 101761861 20 + 1.081 1.054 -0.098
ENSG00000078304 E004 17.6205043 0.0217049693 6.461432e-01 7.581296e-01 14 101761862 101761869 8 + 1.237 1.286 0.174
ENSG00000078304 E005 31.4471153 0.0054396427 3.291993e-01 4.727047e-01 14 101761870 101761884 15 + 1.469 1.546 0.266
ENSG00000078304 E006 60.7252659 0.0009065202 1.801278e-03 6.603209e-03 14 101761885 101761920 36 + 1.716 1.873 0.530
ENSG00000078304 E007 73.3332360 0.0026693065 4.661056e-04 2.030498e-03 14 101762905 101762927 23 + 1.787 1.964 0.597
ENSG00000078304 E008 97.1610147 0.0072756955 8.637527e-04 3.486648e-03 14 101762928 101762970 43 + 1.901 2.088 0.629
ENSG00000078304 E009 82.7194675 0.0045185844 1.379050e-11 2.809213e-10 14 101765154 101765291 138 + 1.750 2.096 1.162
ENSG00000078304 E010 67.8459037 0.0013336295 1.080400e-15 4.060276e-14 14 101765292 101765386 95 + 1.649 2.023 1.264
ENSG00000078304 E011 60.2504155 0.0017955433 7.173363e-18 3.578126e-16 14 101765387 101765448 62 + 1.559 1.992 1.465
ENSG00000078304 E012 225.6492204 0.0006965108 7.703352e-55 6.332040e-52 14 101765449 101766124 676 + 2.143 2.563 1.402
ENSG00000078304 E013 193.8359177 0.0077045945 1.977155e-23 1.836108e-21 14 101766125 101766616 492 + 2.016 2.529 1.713
ENSG00000078304 E014 46.3081097 0.0090217766 1.682020e-10 2.857112e-09 14 101766617 101767049 433 + 1.441 1.900 1.558
ENSG00000078304 E015 60.9286496 0.0004068283 5.271558e-01 6.602936e-01 14 101786018 101786110 93 + 1.789 1.769 -0.067
ENSG00000078304 E016 44.7682739 0.0012023948 9.151370e-01 9.502744e-01 14 101786111 101786120 10 + 1.646 1.663 0.055
ENSG00000078304 E017 58.0220206 0.0004106073 6.383570e-01 7.520027e-01 14 101786121 101786183 63 + 1.747 1.779 0.109
ENSG00000078304 E018 0.0000000       14 101789681 101789896 216 +      
ENSG00000078304 E019 5.6067918 0.0050404182 4.631219e-03 1.490606e-02 14 101797211 101797701 491 + 0.619 0.997 1.499
ENSG00000078304 E020 3.3829386 0.0050308195 2.994068e-01 4.409064e-01 14 101809803 101809833 31 + 0.684 0.525 -0.708
ENSG00000078304 E021 3.3829386 0.0050308195 2.994068e-01 4.409064e-01 14 101809834 101809834 1 + 0.684 0.525 -0.708
ENSG00000078304 E022 3.9010719 0.0040752224 3.354238e-01 4.792090e-01 14 101809835 101809836 2 + 0.723 0.582 -0.605
ENSG00000078304 E023 6.5270132 0.0110172772 2.728338e-01 4.117939e-01 14 101809837 101809865 29 + 0.903 0.757 -0.570
ENSG00000078304 E024 6.6785286 0.0067001548 2.187295e-01 3.488810e-01 14 101809866 101809868 3 + 0.915 0.756 -0.618
ENSG00000078304 E025 45.5111429 0.0079434686 1.686157e-01 2.863624e-01 14 101809869 101809894 26 + 1.686 1.595 -0.310
ENSG00000078304 E026 83.2918010 0.0059695397 2.199974e-02 5.567662e-02 14 101809895 101809904 10 + 1.954 1.831 -0.414
ENSG00000078304 E027 185.6877011 0.0002401015 3.224132e-11 6.176582e-10 14 101809905 101810036 132 + 2.316 2.134 -0.608
ENSG00000078304 E028 0.7029582 0.0169893281 8.874290e-02 1.731955e-01 14 101818027 101818991 965 + 0.088 0.382 2.643
ENSG00000078304 E029 2.4679813 0.0932395634 5.834035e-01 7.075327e-01 14 101818992 101819085 94 + 0.481 0.585 0.487
ENSG00000078304 E030 0.6663248 0.0197958420 6.079636e-03 1.882037e-02 14 101819086 101821098 2013 + 0.000 0.458 11.761
ENSG00000078304 E031 0.0000000       14 101823653 101823877 225 +      
ENSG00000078304 E032 0.0000000       14 101823878 101823881 4 +      
ENSG00000078304 E033 0.0000000       14 101823882 101823941 60 +      
ENSG00000078304 E034 3.9920034 0.0064686522 2.687496e-01 4.072363e-01 14 101824014 101824161 148 + 0.619 0.790 0.708
ENSG00000078304 E035 1.6262051 0.0123837734 2.790918e-01 4.187934e-01 14 101824162 101824169 8 + 0.328 0.525 1.057
ENSG00000078304 E036 2.9097524 0.0060111210 5.423469e-02 1.166600e-01 14 101824170 101824478 309 + 0.448 0.755 1.378
ENSG00000078304 E037 0.0000000       14 101824838 101824922 85 +      
ENSG00000078304 E038 2.7743481 0.0061601719 7.612648e-01 8.451821e-01 14 101831701 101831804 104 + 0.569 0.525 -0.204
ENSG00000078304 E039 24.2208583 0.0601881189 4.135347e-06 2.996821e-05 14 101836169 101836701 533 + 1.046 1.670 2.178
ENSG00000078304 E040 398.6958004 0.0001477298 2.767207e-16 1.127881e-14 14 101856686 101856885 200 + 2.637 2.487 -0.499
ENSG00000078304 E041 0.0000000       14 101879222 101879363 142 +      
ENSG00000078304 E042 211.4120909 0.0002201197 8.209960e-07 6.944157e-06 14 101882161 101882204 44 + 2.354 2.233 -0.405
ENSG00000078304 E043 237.7878546 0.0001890760 7.830264e-05 4.199824e-04 14 101882205 101882271 67 + 2.395 2.307 -0.293
ENSG00000078304 E044 48.4295280 0.0087249306 1.371962e-02 3.758482e-02 14 101882272 101883016 745 + 1.735 1.568 -0.566
ENSG00000078304 E045 163.7305583 0.0002620957 4.654103e-05 2.642053e-04 14 101883257 101883301 45 + 2.240 2.127 -0.380
ENSG00000078304 E046 185.0956270 0.0002302700 1.910088e-05 1.190365e-04 14 101883302 101883349 48 + 2.293 2.181 -0.373
ENSG00000078304 E047 198.7725368 0.0002195674 7.145238e-01 8.106947e-01 14 101883432 101883536 105 + 2.287 2.286 0.000
ENSG00000078304 E048 101.0331978 0.0004812044 3.075771e-01 4.498084e-01 14 101883537 101883562 26 + 1.975 2.022 0.158
ENSG00000078304 E049 1.0705211 0.0122536757 1.994839e-01 3.255940e-01 14 101889793 101889981 189 + 0.224 0.458 1.469
ENSG00000078304 E050 1.3661756 0.0388803996 1.980431e-02 5.106943e-02 14 101889982 101890192 211 + 0.162 0.582 2.641
ENSG00000078304 E051 0.5546650 0.0219302468 2.356600e-01 3.691506e-01 14 101890193 101890236 44 + 0.088 0.288 2.060
ENSG00000078304 E052 133.8439438 0.0002764393 6.644019e-02 1.374595e-01 14 101890237 101890296 60 + 2.092 2.160 0.229
ENSG00000078304 E053 241.4400447 0.0002263817 6.261455e-01 7.421305e-01 14 101893000 101893108 109 + 2.373 2.370 -0.008
ENSG00000078304 E054 222.4469890 0.0001938085 7.926061e-02 1.583332e-01 14 101894507 101894560 54 + 2.348 2.313 -0.116
ENSG00000078304 E055 358.4787261 0.0001763633 3.646302e-01 5.089789e-01 14 101901719 101901856 138 + 2.545 2.536 -0.029
ENSG00000078304 E056 206.2691837 0.0002055285 8.990172e-01 9.395766e-01 14 101901857 101901889 33 + 2.298 2.311 0.043
ENSG00000078304 E057 342.0508308 0.0001839362 3.644485e-01 5.088112e-01 14 101906402 101906504 103 + 2.524 2.515 -0.030
ENSG00000078304 E058 259.2786076 0.0002403547 3.032294e-01 4.451283e-01 14 101906505 101906529 25 + 2.407 2.392 -0.049
ENSG00000078304 E059 1.7004013 0.0120763460 8.692943e-02 1.704780e-01 14 101906530 101906647 118 + 0.279 0.582 1.643
ENSG00000078304 E060 307.1509091 0.0002853980 3.407682e-02 7.990780e-02 14 101909589 101909647 59 + 2.490 2.453 -0.122
ENSG00000078304 E061 274.8737747 0.0005592593 4.841862e-02 1.063632e-01 14 101909648 101909690 43 + 2.442 2.404 -0.126
ENSG00000078304 E062 207.9530249 0.0002059854 1.491940e-01 2.605636e-01 14 101912401 101912404 4 + 2.318 2.290 -0.091
ENSG00000078304 E063 292.8451406 0.0005544855 2.512443e-01 3.874343e-01 14 101912405 101912473 69 + 2.462 2.444 -0.057
ENSG00000078304 E064 124.3573535 0.0100509171 4.048874e-02 9.191697e-02 14 101912474 101912628 155 + 2.032 2.165 0.448
ENSG00000078304 E065 1.0267042 0.0133467876 3.720696e-02 8.586474e-02 14 101914175 101914572 398 + 0.411 0.000 -11.924
ENSG00000078304 E066 0.0000000       14 101917769 101917830 62 +      
ENSG00000078304 E067 39.9654189 0.0014740236 1.430074e-05 9.163647e-05 14 101917831 101917947 117 + 1.681 1.413 -0.916
ENSG00000078304 E068 0.7029582 0.0169893281 8.874290e-02 1.731955e-01 14 101921093 101921382 290 + 0.088 0.382 2.643
ENSG00000078304 E069 2.6206692 0.0151477591 8.513660e-01 9.078336e-01 14 101921984 101922042 59 + 0.542 0.581 0.180
ENSG00000078304 E070 1.7995050 0.0107581214 5.438445e-01 6.743973e-01 14 101922043 101922129 87 + 0.411 0.524 0.569
ENSG00000078304 E071 0.8512514 0.0143722482 3.285420e-02 7.751675e-02 14 101922165 101922198 34 + 0.088 0.459 3.056
ENSG00000078304 E072 925.6560406 0.0014589609 3.087455e-10 5.013793e-09 14 101925141 101927989 2849 + 2.994 2.874 -0.396