ENSG00000078269

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355585 ENSG00000078269 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNJ2 protein_coding protein_coding 6.504369 11.03134 5.009621 0.4385484 0.1809614 -1.137264 2.131786 1.990457 2.507250 0.1226378 0.09248888 0.331519 0.3848333 0.1801333 0.5006000 0.3204667 1.806193e-17 3.495232e-20 FALSE TRUE
ENST00000367113 ENSG00000078269 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNJ2 protein_coding protein_coding 6.504369 11.03134 5.009621 0.4385484 0.1809614 -1.137264 4.156693 8.788785 2.210111 0.3716501 0.07252287 -1.986672 0.5761792 0.7965667 0.4414667 -0.3551000 3.495232e-20 3.495232e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078269 E001 18.2242685 0.0156382768 5.301665e-01 6.628157e-01 6 157981863 157981953 91 + 1.237 1.303 0.231
ENSG00000078269 E002 23.7756218 0.0337850816 2.048502e-01 3.322113e-01 6 157981954 157982037 84 + 1.294 1.440 0.508
ENSG00000078269 E003 20.8069850 0.0050230800 1.279455e-03 4.908447e-03 6 157982038 157982088 51 + 1.151 1.427 0.970
ENSG00000078269 E004 0.4448795 0.5009222183 2.803270e-01 4.201845e-01 6 158017048 158017203 156 + 0.000 0.271 11.759
ENSG00000078269 E005 42.4113323 0.0023352154 1.617698e-07 1.578756e-06 6 158017204 158017290 87 + 1.425 1.744 1.088
ENSG00000078269 E006 0.8502072 0.0144104535 7.701866e-01 8.516088e-01 6 158017465 158017795 331 + 0.228 0.283 0.408
ENSG00000078269 E007 1.0673860 0.0344574481 5.208703e-01 6.548148e-01 6 158027367 158028755 1389 + 0.228 0.348 0.828
ENSG00000078269 E008 105.5365203 0.0017142103 1.327166e-18 7.195984e-17 6 158028756 158029026 271 + 1.787 2.141 1.191
ENSG00000078269 E009 0.9211812 0.0136968632 2.429935e-02 6.043401e-02 6 158029027 158029406 380 + 0.000 0.403 13.759
ENSG00000078269 E010 84.9841618 0.0003440259 1.260680e-43 5.403441e-41 6 158030408 158030937 530 + 1.483 2.097 2.075
ENSG00000078269 E011 12.1653529 0.0060908836 3.185160e-01 4.614919e-01 6 158033455 158033489 35 + 1.171 1.079 -0.331
ENSG00000078269 E012 25.4958867 0.0014050422 7.547855e-02 1.522820e-01 6 158033490 158033680 191 + 1.483 1.368 -0.397
ENSG00000078269 E013 15.8929991 0.0013414264 7.757933e-02 1.555763e-01 6 158043316 158043399 84 + 1.294 1.151 -0.505
ENSG00000078269 E014 13.4182467 0.0012821810 1.671289e-01 2.844674e-01 6 158054967 158055028 62 + 1.219 1.101 -0.421
ENSG00000078269 E015 12.4733039 0.0014224766 1.340461e-01 2.397711e-01 6 158059257 158059353 97 + 1.191 1.057 -0.481
ENSG00000078269 E016 0.8105550 0.0148393207 1.299166e-01 2.340472e-01 6 158059354 158059537 184 + 0.377 0.116 -2.175
ENSG00000078269 E017 9.9214346 0.0016989960 2.446566e-01 3.796433e-01 6 158061992 158062054 63 + 1.094 0.981 -0.414
ENSG00000078269 E018 16.2793500 0.0026458983 8.413472e-02 1.660251e-01 6 158062055 158062164 110 + 1.309 1.169 -0.493
ENSG00000078269 E019 15.5240632 0.0012166434 1.708205e-01 2.892383e-01 6 158063791 158063872 82 + 1.271 1.160 -0.390
ENSG00000078269 E020 20.9224282 0.0030580375 2.541197e-02 6.272928e-02 6 158064601 158064750 150 + 1.419 1.252 -0.584
ENSG00000078269 E021 22.5307430 0.0188014775 6.054245e-01 7.258175e-01 6 158064826 158064991 166 + 1.384 1.339 -0.156
ENSG00000078269 E022 27.1212726 0.0059110891 1.925255e-01 3.169283e-01 6 158066444 158066635 192 + 1.488 1.397 -0.313
ENSG00000078269 E023 11.1686153 0.0768691071 3.281249e-03 1.109525e-02 6 158068647 158068728 82 + 1.296 0.810 -1.781
ENSG00000078269 E024 15.4002575 0.0196814632 2.148029e-03 7.684012e-03 6 158069533 158069673 141 + 1.365 1.046 -1.133
ENSG00000078269 E025 0.2214452 0.0390650741 5.475103e-01   6 158070128 158070506 379 + 0.000 0.116 11.375
ENSG00000078269 E026 15.8501085 0.0013167014 1.056225e-06 8.722310e-06 6 158071602 158071794 193 + 1.408 0.995 -1.468
ENSG00000078269 E027 13.5449054 0.0147860509 1.865111e-05 1.165253e-04 6 158074580 158074738 159 + 1.364 0.905 -1.652
ENSG00000078269 E028 16.7212598 0.0026756973 3.359403e-08 3.748330e-07 6 158076626 158076782 157 + 1.452 0.981 -1.673
ENSG00000078269 E029 1.1115096 0.0510870926 4.215227e-02 9.500472e-02 6 158077680 158078163 484 + 0.488 0.116 -2.757
ENSG00000078269 E030 15.4045915 0.0012115469 1.628071e-08 1.929637e-07 6 158078164 158078281 118 + 1.425 0.937 -1.743
ENSG00000078269 E031 0.0000000       6 158078282 158079356 1075 +      
ENSG00000078269 E032 25.8574817 0.0089753463 1.104570e-03 4.318415e-03 6 158081109 158081327 219 + 1.552 1.300 -0.869
ENSG00000078269 E033 16.9369432 0.0065844562 5.618953e-02 1.200329e-01 6 158081432 158081510 79 + 1.338 1.178 -0.563
ENSG00000078269 E034 24.8229460 0.0025227638 5.863012e-04 2.483022e-03 6 158083429 158083597 169 + 1.525 1.287 -0.824
ENSG00000078269 E035 19.3897567 0.0010683932 8.863347e-07 7.445559e-06 6 158084001 158084174 174 + 1.478 1.102 -1.321
ENSG00000078269 E036 11.7609988 0.0015652232 5.388875e-03 1.698453e-02 6 158086855 158086989 135 + 1.228 0.967 -0.945
ENSG00000078269 E037 10.0152027 0.0017746125 1.586791e-02 4.244024e-02 6 158088660 158088772 113 + 1.161 0.921 -0.878
ENSG00000078269 E038 10.3798580 0.0017941228 1.707172e-02 4.509650e-02 6 158089839 158089947 109 + 1.171 0.937 -0.855
ENSG00000078269 E039 15.1156307 0.0011817428 3.661009e-02 8.473326e-02 6 158092926 158093104 179 + 1.294 1.122 -0.610
ENSG00000078269 E040 0.9996463 0.0131592973 8.691059e-01 9.198773e-01 6 158093888 158094094 207 + 0.309 0.283 -0.177
ENSG00000078269 E041 238.1196701 0.0040188121 5.428691e-01 6.735663e-01 6 158095618 158099176 3559 + 2.359 2.386 0.089